Abstract:
:For assessment of the effect of trihexiphenidil on the excitability state of the alpha-motoneurons of the plantar flexor of the foot in patients with drug-induced parkinsonian rigidity curves of the excitability of motoneurons of the soleus muscle were plotted in two variants of experiments: I. with afferent stimulation of the Ia fibres of the soleus muscle as the conditioning and testing stimulus (tibial nerve in the popliteal fossa), II. with afferent stimulation of Ia fibres of the anterior tibial muscle (peroneal nerve behind the fibular capitulum) used as the conditioning stimulus and stimulation of the tibial nerve as the testing stimulus. These investigations were carried out on 12 psychiatric patients who received no drugs at the time of these investigations (control group), 13 similar patients treated with chlorpromazine, 12 treated with phenothiazine compounds with piperazine ring in the side chain. The investigations were repeated 30-50 min. after oral administration of trihexiphenidil 5 mg. In variant I typical excitability curves were obtained and 5 phases could be discerned in them. In patients treated with piperazine-containing phenothiazine derivatives inducting more significant parkinsonian effects phase III - depression - was significantly shortened, and the excitability was raised in phase IV. In variant II phases III and IV were reversed and in phase IV a rise in excitability was observed in place of depression. In variant II in the group of drug-induced parkinsonism as compared with controls the rise in exictability was greater in phase III and depression in phase IV was smaller. The effect of trihexiphenidil in variant I depended on the initial state. In controls and in patients treated with chlorpromazine trihexiphenidil reduced the duration of phase III of depression and decreased its intensity. In atients treated with phenothiazines containing the piperazine ring depression in phase III was weak but increased after trihexiphenidil administration and increased excitability in phase IV was decreased. The curves became similar to those obtained in controls. In variant II in the control group excitability in phase III increased after trihexiphenidil administration.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Zakrzewska Fsubject
Has Abstractpub_date
1975-01-01 00:00:00pages
15-24issue
1eissn
0028-3843issn
1897-4260journal_volume
9pub_type
杂志文章abstract::The authors analysed 95 SEEG records in epileptics with prevalent temporal-lobe changes comparing the bioelectric activity of the brain recorded simultaneously in the amygdala, hippocampus, temporal cortex and cranial surface during these investigations and relating them to EEG records obtained before the operation. I...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:OBJECTIVES:The main aim of the study was to find the effect of hyperdense middle cerebral artery sign (HMCAS), as the only admission computed tomography (CT) manifestation of ischemic stroke involving middle cerebral artery (MCA) region, on the extent of stroke measured by Alberta Stroke Program Early CT score (ASPECTS...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2016.10.003
更新日期:2017-01-01 00:00:00
abstract::Three cases are presented of familial myasthenia gravis: two sisters and their cousin. Healthy members of this family were also examined. Myasthenia gravis was diagnosed on the ground of the clinical and electrophysiological examination (decrement test and SF EMG with jitter evaluation) as well as of the immunological...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::The authors present the results of treating acute hemispheric stroke with intravenous nimodipine. 17 patients were additionally treated with nimodipine given intravenously in 1 mg-2 mg dose, and the control group consisted of 71 patients treated in standard way with Dextran 40,000. The selection of patients for the st...
journal_title:Neurologia i neurochirurgia polska
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-05-01 00:00:00
abstract::The pathogenesis of cervical migraine may suggest that a connection exists between it and cervical discopathy and also vertebrobasilar arterial insufficiency. This correlation was studied in a group of 103 patients subjected to clinical observations. In 83 of them cervical discopathy was found, in 69 cervical migraine...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract::Terminal ventriculostomy is one of the methods used in surgical treatment of syringomyelia. The procedure is well tolerated and may be used in cases in which atlanto-occipital decompression is too serious an operation. The author used the method in treatment of 10 patients with different stages of syringomyelia. In 5 ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract:OBJECTIVE:Presentation of our experience in the treatment of anterior clinoidal meningiomas, including evaluation of factors that may affect early and long-term treatment outcomes. METHODS:Thirty patients were operated with strategy of complete tumor resection using fronto-orbito-zygomatic approach. Outcomes were asse...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2015.01.003
更新日期:2015-01-01 00:00:00
abstract::Benign spinal neoplasm (b.s.n.) represented 11% (8 cases) of all histopathologically verified spinal neoplasm in 85 patients operated on between 1975 and 1990. Local back or neck pain were first clinical symptoms of b.s.n. On admission all the patients presented with bone lesions on X-ray plain radiograms of the spine...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::The identification of reliable biomarkers of Parkinson's disease (PD) is a pivotal step in the introduction of causal therapies. Saliva is a biofluid which may be involved in synuclein pathology in PD. We have reviewed current studies on salivary proteins and compounds in PD patients and healthy controls, and their po...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:10.5603/PJNNS.a2020.0011
更新日期:2020-01-01 00:00:00
abstract::The aim of the study was to assess the occurrence of headache in acute ischaemic stroke and its association with type, aetiology and localization of stroke. 342 patients with stroke were analysed. Their average age was 70.8 +/- 13.1. Headache was observed in 17.8% stroke patients. There was no correlation between head...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::The authors present two patients treated surgically for intracranial aneurysms. Within 2.5 and 4.6 years after surgery the repeated angiography performed after the second SAH revealed newly formed aneurysms in another localisation. These facts became a contribution to the etiopathogenetic considerations. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::In a group of 139 patients with poorly differentiated brain gliomas controlled clinical trial was carried out for assessment of two methods of postoperative treatment. After possibly radical removal of the glioma the patients were treated by radiotherapy with 60Co teletherapy in doses of 60 Gy (30 fr) in depth during ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1988-05-01 00:00:00
abstract::The acute phase of spinal cord injury includes primary and secondary pathological patterns. Primary patterns include the effects of contusion, laceration, stretch of neural tissue and direct vascular trauma. These changes are irreversible. Secondary patterns include posttraumatic ischemic changes, loss of energy metab...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract:AIM OF THE STUDY:This paper describes six cases of patients with myoclonus-dystonia syndrome who are members of a family in which an SGCE gene mutation has been confirmed. CLINICAL RATIONALE FOR THE STUDY:Myoclonus-dystonia syndrome is a very rare disease, with an incidence in Europe of about 2 in every million. Due t...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.5603/PJNNS.a2020.0005
更新日期:2020-01-01 00:00:00
abstract::Authors evaluated the activity of c-AMP in the CSF as the biochemical marker for evaluation of epileptic seizure activity in patients with epilepsy. The impact of monitored phenytoin treatment on c-AMP activity in CSF was investigated. It was shown that the general tonic-clonic seizures cause a significant concentrati...
journal_title:Neurologia i neurochirurgia polska
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::In the group of 132 patients with diagnosed pseudoradicular pain syndrome (57 subjects) or evident sciatic neuralgia (75 subjects) besides clinical and radiological examination, additional skin electro-conduction evaluation, being the sympathetic system activity exponent, was performed. Diagnostic part of empiric meth...
journal_title:Neurologia i neurochirurgia polska
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus (Vim) has been recently introduced by Benabid and his colleagues as a new surgical procedure in the treatment of tremor-dominant Parkinson's disease (PD). The advantage of DBS Vim over lesioning (thalamotomy) is its reversibility and adjustabili...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::In the Province of Szczecin in the period 1993-1995 the incidence was 2.16 and the prevalence 55.32/100,000 on December 31 1995. Incidence and prevalence were higher in women (the difference was higher in Szczecin City) what was not connected with a significantly greater number of women in the population of the provin...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::Cervicothoracic junction and upper thoracic spine down to T4 can be reached through anterior approach via sternotomy. Transsternal approach is the best route to gain access to lesions localized within vertebral bodies of the upper thoracic spine allowing for their resection, interbody fusion and replacement with bone ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::In 1984 the authors determined by radioimmunoassay (ORIPI-RIA kit) the serum growth hormone levels in 35 patients with multiple sclerosis (20 M, 15 F) aged from 20 to 54 years, and in 10 cases the determination was carried out in the cerebrospinal fluid (CSF). The control group comprised 40 patients with ischialgia or...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::52 clinically definite multiple sclerosis (MS) patients were treated with subcutaneous injection of 5 mg 2-CDA in 5 consecutive days. The injection courses were repeated 6 times in one month interval. The MRI pattern and immunological markers were studied in serum and CSF before and after 6 months of treatment. The ob...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to evaluate our surgical experience with intracranial meningiomas in NF2 patients and provide knowledge of the natural history of these lesions. METHODS:We included in the natural growth study patients with the diagnosis of NF2 who harbored intracranial meningiomas and were observed ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2015.08.007
更新日期:2015-01-01 00:00:00
abstract::The authors report a case of coexistence of Eales disease and multiple sclerosis in which signs of perivenous retinitis preceded by 25 years the appearance of neurological changes. Considering the similarity in the course of both disease and the histological character of perivascular changes the authors suggest presen...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The outcome in acute stroke strongly depends on patient-related issues, as well as on the availability of human and diagnostic resources. Our aim was to evaluate safety and effectiveness of intravenous alteplase for stroke according to the time of admission to the hospital. MATERIALS AND METHODS...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2013.12.003
更新日期:2014-01-01 00:00:00
abstract::The author described a case of myasthenia and epilepsy in a female aged 36 years. The relationship between myasthenia and epilepsy was discussed. The additional factor which made the diagnosis difficult is bilateral deafness. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The study performed in 30 normal subjects (24F, 6M) with age range 18-55 years and height range 154-188 cm. Electrical stimulation was applied to the tibial nerves and direct response M and F-wave was recorded from right and left SOLEUS (60 examinations). Transcranial and paravertebral (S1 level) magnetic stimulation ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Headaches belong to the most frequent sufferings. According to certain most modern epidemiological studies about 20% of adults have recurrent headaches, among them particularly migraine and tension headache. In recent years the interest in these conditions had increased resulting in a great number of research works. A...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:To date, there has been no clear evidence regarding the evaluation of saccades as a monitoring tool of motor impairment in Parkinson's disease (PD) Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) patients. The aim of this study was to evaluate the long-term impact of STN-DBS and pharmacological treatm...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.5603/PJNNS.a2019.0045
更新日期:2019-01-01 00:00:00
abstract::Disturbances of and difficulties in psychosocial adaptation were analysed in 63 epileptics (with generalized convulsions and partial complex seizures) and in 31 subjects without diseases of the central nervous system (control group). The disturbances of adaptation were not more frequent in epileptics than in controls....
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The authors report a case of Jakob-Creutzfeldt disease diagnosed at autopsy. In the discussion attention is called to characteristic clinical manifestations and possibilities of intravital diagnosis of the disease. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00