Clinical pharmacology of anti-epileptic drugs: a summary of current information.

abstract：BACKGROUND:Plasma concentrations of the peptides midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), and C-terminal endothelin-1 precursor fragment (CT-proET-1) are increased in various cardiovascular conditions. However, there is limited information about the association a...

journal_title：Clinical chemistry

authors： Kollerits B,Sturm G,Lamina C,Hammerer-Lercher A,Rantner B,Stadler M,Ziera T,Struck J,Klein-Weigel P,Fraedrich G,Kronenberg F

更新日期：2013-04-01 00:00:00

abstract：:We present a unified approach to the use of linear models and matrix least squares with the intention of providing a better understanding of the techniques themselves and of the statistics that arise from these techniques as they are used in clinical chemistry. Emphasis is placed on the importance of appropriate exper...

journal_title：Clinical chemistry

authors： Deming SN,Morgan SL

更新日期：1979-06-01 00:00:00

abstract：:17 alpha-Hydroxyprogesterone, cortisol, and 11-deoxycortisol were extracted with methylene chloride, separated by liquid chromatography, identified by their retention times, and quantitated by monitoring the absorbance at 254 nm. The method is specific and sensitive to as little as 2.5 ng of 17 alpha-hydroxyprogestero...

journal_title：Clinical chemistry

authors： Canalis E,Caldarella AM,Reardon GE

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Calcitonin (CT) is a sensitive marker for evaluation of medullary thyroid cancer (MTC). However, CT measurement can vary with assay- and nonassay-dependent factors, and procalcitonin (PCT) measurement has been proposed for evaluating questionable increases in CT. METHODS:We tested 2 fully automated CT assay...

journal_title：Clinical chemistry

authors： Kratzsch J,Petzold A,Raue F,Reinhardt W,Bröcker-Preuss M,Görges R,Mann K,Karges W,Morgenthaler N,Luster M,Reiners C,Thiery J,Dralle H,Fuhrer D

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Monitoring of the concentration of gentamicin in serum and plasma during therapy is widely recommended and practiced in hospitals. Our aim was to develop a homogeneous immunoassay based on particle-enhanced turbidimetric inhibition immunoassay technology to quantify gentamicin on the Dimension clinical chemi...

journal_title：Clinical chemistry

authors： Wei TQ,Chu VP,Craig AR,Duffy JE,Obzansky DM,Kilgore D,Masulli IS,Sanders CM,Thompson JC

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Clinical assessment of vitamin D status often relies on measuring total circulating 25-hydroxyvitamin D3 (25OHD3), but much of each vitamin D metabolite is bound to plasma vitamin D-binding protein (DBP), such that the percentage of free vitamin is very low. We hypothesized that measurement of free rather th...

journal_title：Clinical chemistry

authors： Al-oanzi ZH,Tuck SP,Raj N,Harrop JS,Summers GD,Cook DB,Francis RM,Datta HK

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Prostate-specific antigen (PSA) is an important marker for the diagnosis and management of prostate cancer, and the free PSA/total PSA ratio has been shown to be efficient for distinguishing prostate cancer from benign prostatic hyperplasia. We report here the characterization of seven mouse monoclonal antib...

journal_title：Clinical chemistry

authors： Michel S,Deléage G,Charrier JP,Passagot J,Battail-Poirot N,Sibai G,Jolivet M,Jolivet-Reynaud C

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Uremic syndrome is the consequence of the retention of solutes usually cleared by the healthy kidneys. p-Cresol can be considered a prototypic protein-bound uremic toxin. It is conceivable, analogous with drugs, that the non-protein-bound fraction of p-cresol exerts toxicity. This aspect had never been evalu...

journal_title：Clinical chemistry

authors： De Smet R,Van Kaer J,Van Vlem B,De Cubber A,Brunet P,Lameire N,Vanholder R

更新日期：2003-03-01 00:00:00

abstract：:I evaluated use of the fluorescence polarization technique to measure neocarzinostatin, a proteinaceous antitumor antibiotic, and its antibody, in serum. The antigen (neocarzinostatin), labeled with fluorescein isothiocyanate, was allowed to interact with its antibody in a cuvet, in the instrument, yielding an increas...

journal_title：Clinical chemistry

authors： Maeda H

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:It is important that cardiac troponin be measured accurately with a robust method to limit false results with potentially adverse clinical outcomes. In this study, we characterized the robustness of 4 analytical platforms by measuring the outlier rate between duplicate results. METHODS:We measured cardiac t...

journal_title：Clinical chemistry

authors： Pretorius CJ,Dimeski G,O'Rourke PK,Marquart L,Tyack SA,Wilgen U,Ungerer JP

更新日期：2011-05-01 00:00:00

abstract：:This improved assay of rheumatoid factors in serum, described here for use with the Baker "Encore" centrifugal analyzer, is efficient, with 250-sample throughput per hour; reproducible, with between-batch CV = 5% and within-batch CV = 2% (mid-assay range); and results correlate well (r = 0.9) with those by other metho...

journal_title：Clinical chemistry

authors： Winkles JW,Lunec J,Gray L

更新日期：1989-02-01 00:00:00

abstract：:A digestion procedure involving nitric acid is described for determination of aluminum in blood, serum, and plasma by graphite-furnace atomic absorption spectroscopy. Contamination was not a severe problem if all operations were performed in a dust-free atmosphere. Conditions for such determination of aluminum in bloo...

journal_title：Clinical chemistry

authors： Frech W,Cedergren A,Cederberg C,Vessman J

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Massively parallel sequencing has recently been used in noninvasive prenatal diagnosis. The current costs of this technology are still relatively expensive, however, and sample throughput is still relatively low when it is used as a molecular diagnostic tool. Rather than nonselectively sequencing the genome,...

journal_title：Clinical chemistry

authors： Liao GJ,Lun FM,Zheng YW,Chan KC,Leung TY,Lau TK,Chiu RW,Lo YM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The time required for bloodstream pathogen detection, identification (ID), and antimicrobial susceptibility testing (AST) does not satisfy the acute needs of disease management. Conventional methods take up to 3 days for ID and AST. Molecular diagnostics have reduced times for ID, but their promise to suppla...

journal_title：Clinical chemistry

authors： Andini N,Hu A,Zhou L,Cogill S,Wang TH,Wittwer CT,Yang S

更新日期：2018-10-01 00:00:00

abstract：:A modified heparin-Sepharose affinity chromatography procedure (Boberg et al., J. Lipid Res. 18:544-547, 1977) was developed to determine two different triglyceride lipase activities in human post-heparin plasma: hepatic triglyceride lipase (I) and lipoprotein lipase (II). With this procedure, lipoproteins were separa...

journal_title：Clinical chemistry

authors： Wang CS,Bass HB,Downs D,Whitmer RK

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:The analytical and clinical performance of homogeneous LDL-cholesterol assays has been reported, but their reactions with subfractions of LDL and VLDL have not been described in detail. METHODS:We evaluated reaction selectivity of two homogeneous LDL-cholesterol assays, LDLk (Kyowa Medex) and LDLd (Daiichi ...

journal_title：Clinical chemistry

authors： Usui S,Kakuuchi H,Okamoto M,Mizukami Y,Okazaki M

更新日期：2002-11-01 00:00:00

abstract：:We evaluated the density-gradient ultracentrifugation method in a swinging-bucket rotor (Anal Biochem 111, 149-157, 1981) in a slightly modified version for isolation and determination of high-density lipoprotein (HDL) subfractions. We prestained the serum with Coomassie Brilliant Blue R, which did not change the hydr...

journal_title：Clinical chemistry

authors： Demacker PN,van Sommeren-Zondag DF,Stalenhoef AF,Stuyt PM,van't Laar A

更新日期：1983-04-01 00:00:00

abstract：:We have developed an HPLC method for measuring carbamylated hemoglobin (CarHb), based on the quantification of valine hydantoin formed from the released NH2-terminal carbamyl valine residue after acid hydrolysis of hemoglobin. In uremia, CarHb is produced by nonenzymatic post-translational modification of the terminal...

journal_title：Clinical chemistry

authors： Kwan JT,Carr EC,Bending MR,Barron JL

更新日期：1990-04-01 00:00:00

abstract：INTRODUCTION:Parathyroid hormone-related peptide (PTHrP) is involved in activating pathways, allowing tumor cells to form bone metastases. Measurement of PTHrP is used for the diagnosis and clinical management of patients suspected of hypercalcemia of malignancy. We developed an LC-MS/MS method for measuring PTHrP, est...

journal_title：Clinical chemistry

authors： Kushnir MM,Rockwood AL,Strathmann FG,Frank EL,Straseski JA,Meikle AW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Detection of circulating tumor cells (CTCs) in the peripheral blood is a rapidly developing research field with clear clinical implications for the staging and monitoring of cancer patients. Current CTC assays, including the US Food and Drug Administration-cleared CellSearch® system, typically use markers [e...

journal_title：Clinical chemistry

authors： Pantel K,Denève E,Nocca D,Coffy A,Vendrell JP,Maudelonde T,Riethdorf S,Alix-Panabières C

更新日期：2012-05-01 00:00:00

abstract：:In response to the pressures of cost reduction, we established and evaluated a carefully integrated program to deliver clinical laboratory services more promptly and efficiently to the intensive care units (ICUs). The new protocol reduced the steps and turnaround time from ordering tests by physicians to reporting res...

journal_title：Clinical chemistry

authors： Steffes MW,Gillen JL,Fuhrman SA

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:High circulating concentrations of N-terminal fragments of A- and B-type natriuretic peptides (NT-proANP and NT-proBNP) identify patients with impaired cardiac function. ProANP-derived peptides are particularly sensitive to increased preload of the heart and proBNP-derived peptides to increased afterload; th...

journal_title：Clinical chemistry

authors： Ala-Kopsala M,Ruskoaho H,Leppäluoto J,Seres L,Skoumal R,Toth M,Horkay F,Vuolteenaho O

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The antiphospholipid syndrome (APS) is an important cause of acquired thromboembolic complications and pregnancy morbidity. Its diagnosis is based on clinical and laboratory criteria, defined by strict guidelines. The original clinical and laboratory criteria for the identification of APS patients were publi...

journal_title：Clinical chemistry

authors： Devreese K,Hoylaerts MF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The alteration of the bone microenvironment as a consequence of skeletal metastases is poorly understood. The aim of this study was to search for patterns of bone markers in relation to primary tumor type, bone pain, and number of sites involved in patients with bone metastases. METHODS:We studied 323 patie...

journal_title：Clinical chemistry

authors： Berruti A,Dogliotti L,Gorzegno G,Torta M,Tampellini M,Tucci M,Cerutti S,Frezet MM,Stivanello M,Sacchetto G,Angeli A

更新日期：1999-08-01 00:00:00

abstract：:We have developed and evaluated a new procedure for detecting trends in quality-control measurements and applied it to laboratory data. The method requires the use of sequential or "moving" slope estimates to identify trends. Formulae are derived to estimate the regression error for the moving slope directly from the ...

journal_title：Clinical chemistry

authors： Smith SJ,Myers GL

更新日期：1991-03-01 00:00:00

abstract：:A fluorometric assay for free erythrocyte porphyrins (FEP) is described in detail, the direct test being used for the analysis of blood specimens collected with anticoagulants and the spot test for analysis of blood specimens collected on filter paper. A method for determining the amount of blood absorbed by different...

journal_title：Clinical chemistry

authors： Piomelli S

更新日期：1977-02-01 00:00:00

abstract：:Applying the principles of chemometrics can lead to development of a powerful, simple, comprehensive system for characterizing measurement reliability of analytical processes. The system described here consists of a format for specifications, definitions, and decision rules for evaluating and comparing analytical proc...

journal_title：Clinical chemistry

authors： Castañeda-Méndez K

更新日期：1988-12-01 00:00:00

abstract：:A new, highly sensitive immunoradiometric thyrotropin (TSH) assay involving solid-phase-coupled monoclonal antibodies (Boots-Celltech Sucrosep IRMA-TSH) has been evaluated in a wide variety of patients with thyroidal and nonthyroidal illnesses and the results compared with those obtained by conventional diagnostic TSH...

journal_title：Clinical chemistry

authors： Bassett F,Eastman CJ,Ma G,Maberly GF,Smith HC

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:High-sensitivity C-reactive protein (hsCRP) testing is relatively inexpensive and has been shown to predict the risk of cardiovascular disease (CVD) and diabetes in multiple patient groups, including those treated with statin therapy. JUPITER (Justification for the Use of Statins in Primary Prevention: An In...

journal_title：Clinical chemistry

authors： Mora S,Musunuru K,Blumenthal RS

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Recent studies have suggested that glial fibrillary acidic protein (GFAP) serum concentrations distinguish between intracerebral hemorrhage (ICH) and ischemic stroke (IS) shortly after symptom onset. In this prospective multicenter trial we validated GFAP in an independent patient cohort and assessed the qua...

journal_title：Clinical chemistry

authors： Luger S,Witsch J,Dietz A,Hamann GF,Minnerup J,Schneider H,Sitzer M,Wartenberg KE,Niessner M,Foerch C,BE FAST II and the IGNITE Study Groups.

更新日期：2017-01-01 00:00:00