Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands.

Abstract:

OBJECTIVE:To compare the familial clustering of affective disorders among first-degree relatives of prepubertal versus adult probands with mood disorders. METHOD:The Family History-Research Diagnostic Criteria (FH-RDC) assessment instrument was used to obtain data on first-degree relatives of all probands. Logistic regression was used to assess the strength of the age of the proband to predict FH-RDC diagnoses in relatives. Survival analysis was used to examine the age-at-onset distribution of first FH-RDC diagnosis while controlling for year of birth. RESULTS:The prevalence of major affective disorders was more than two times higher among first-degree relatives of child probands versus those of adult probands even when controlling for birth cohort. Cumulative risk for lifetime major mood disorders in first-degree relatives of child probands was significantly higher than for those of adult probands. CONCLUSION:These analyses further support that ascertainment of families through affected children identifies pedigrees with a higher proportion of affected relatives than ascertainment through affected adults.

authors

Neuman RJ,Geller B,Rice JP,Todd RD

doi

10.1097/00004583-199704000-00008

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

466-73

issue

4

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)62516-8

journal_volume

36

pub_type

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