Abstract：
:The analysis of the genetic causes of tumor development led to the identification of many genes affected in these diseases, which play a role in the control of cell proliferation and apoptosis. However, these studies also suggested that not all alterations are equal with regard to their effect on tumor growth, and they demonstrated that the deregulation of the classical cytoplasmic cascade made up by Ras-Raf-MEK and ERK plays a critical role in tumor development. These findings also raise the hope that via interference with a single pathway growth of a tumor carrying multiple genetic alterations will be affected.
journal_name
Zentralbl Chirjournal_title
Zentralblatt fur Chirurgieauthors
Troppmair J,Rapp URsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
12-5eissn
0044-409Xissn
1438-9592journal_volume
125 Suppl 1pub_type
杂志文章abstract：:Only a few therapeutic approaches in colon cancer therapy are based on controlled study results. Via an internet search using different search strategies 965 abstracts written about colon cancer therapy between 1980-2000 were analysed. Studies focussing on adjuvant therapy were not included. We found 446 retrospective...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,评审
doi：10.1055/s-2001-14799
更新日期：2001-04-01 00:00:00
abstract：UNLABELLED:Over a long time laparascopy for pancreatic diseases was performed only as staging laparoscopy in order to find hidden metastasis. The laparoscopic pyloric preserving duodeno-pancreatectomy showed many problems and could not establish. Laparoscopic distal resection of pancreas is much more feasible due to la...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-2006-947366
更新日期：2006-08-01 00:00:00
abstract：:By checking the list of local anaesthetics produced in the GDR containing vasoconstrictor drugs it could be proved that there exist disproportions concerning maximum concentrations and maximum doses of the local anaesthetic on the one hand and epinephrine as well as norepinnephrine concentration on the other. This dan...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:In a ten years period 186 extravesical antireflux operations (Lich-Gregoir) were performed in 145 children. Indications, surgical technique, postoperative complications, reflux recurrence, and pyelonephritis are described and discussed with regard to the literature. In 66 children followed up for more than 4 years the...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Surgical tactics for the teatment of complicated diverticulitis are in constant evolution and remain a subject of controversy. Amongst 53 patients operated on for complicated sigmoid diverticulits over a 10 year period in our hospital, 29 underwent a Hartmann's procedure (3 Hinchey's stage II, 19 stage III and 7 stage...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:Widely normal stability of the vertebral column with adequate load-bearing capacity should be achieved, following osseous reconstruction of a defect area from which benign tumours or tumour-like lesions had been removed by radical surgery. In malignant processes, surgical tumour removal may add to the effectiveness of...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Early postoperative intestinal motility after conventional and laparoscopic cholecystectomy was registered in dogs (n = 10) by implanted serosal electrodes to compare the abdominal trauma. In addition postoperative adhesions after laparoscopic and conventional resection of the cecum were measured in dogs (n = 14). A s...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:By introduction of laparoscopic cholecystectomy, an increase of accidental common bile duct injuries up to 1.2% has been reported. In the present study of 325 cholecystectomies we evaluated whether mandatory intraoperative cholangiography (IOC) can reduce the rate of accidental bile duct injuries or, at least, identif...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Out of 279 cases of elective radical colonic surgery 109 complicated cases are dealt with. Most of them (66%) were caused by infection. The postoperative mortality came up to 10%. Three quarters of the postoperative deaths were caused by septicaemia and gastrointestinal bleeding. Some of the complications can be effec...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:In a period of 10 years we carried out two prospective multicentric trials to evaluate the state of the art in treatment of appendicitis. One study was performed before introduction of laparoscopy. Important criteria like new diagnostic methods (sonography, laparoscopy), frequency of operation, perforation rate, frequ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The case history of a 75 year old man is demonstrated, who developed an abscess in the scar after B-II-resection 30 years ago. In this abscess S. typhi murium was detected. Diabetes mellitus was an additional risk factor. A review of the literature is given concerning extraintestinal manifestations of salmonellosis wi...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The combined lesion of the anterior cruciate ligament (ACL) with simultaneous or secondary meniscal tears has severe consequences for the knee joint. By a synopsis of the literature and own experimental investigations in sheep it can be shown that in ACL deficient knees secondary meniscal lesions occur, what finally e...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:Assessment of quality of life after foot injuries. METHODS:All patients with foot injuries treated operatively from July 1995 to December 1999 were asked to complete the SF-36 health survey. Values of four subgroups (male with foot injuries without any other injury, multiple injured male with foot injuries, ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-2002-24244
更新日期：2002-03-01 00:00:00
abstract：PATIENTS AND METHODS:In a retrospective study, the results of percutaneous transhepatic therapy of bile duct stones under cholangioscopic control (PTCS) were evaluated in 32 patients in which a endoscopic retrograde stone removal was impossible or failed. RESULTS:Previous gastric surgery was the most common reason for...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:From 1956 to 1982, 4126 patients suffering from rectal cancer underwent surgery, 3229 of them had radical operations. The total postoperative mortality rate came up to 7.1% (n = 295) in the radical operated group it was 6.6% (n = 214). Between 1956 to 1982 continence preserving surgical procedures were constantly on t...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The authors report on their experience concerning myocardial protection during open heart surgery making use of hypothermic cardioplegia. From September 1977 to April 1980 they operated on 637 patients applying this method. 155 cases were evaluated. Hypothermic cardioplegia extends the tolerance of the myocardium to i...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:With 44.9 % trauma is the main cause of death in men under 40 years. From September 3(rd) 1997 to June 30(th) 1998 174 patients with severe injuries or polytrauma were treated in our hospital. The mean ISS was 29 (18-75). 15 (8.75 %) patients died within the first 24 hours. The mean age was 34.5 (2-85) years. The mean...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-2001-19658
更新日期：2001-12-01 00:00:00
abstract：AIM OF THE STUDY:The surgical technique of transoral diverticulostomy by a modified Endo-GIAtrade mark Stapler (Multifire Endo GIA, Tyco Healthcare) is described. Experiences of this procedure in 31 patients are analysed and compared with different endoscopic and conventional surgical therapies of Zenker's diverticula,...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-2007-981312
更新日期：2007-10-01 00:00:00
abstract：:Treatment was applied to 181 patients for acute pancreatitis at the Surgical Department of Friedrichshain Local Hospital, between December 1, 1985 and October 30, 1987. Ninety-two of these patients were in Stage I according to Kümmerle-Hollender, 62 in Stage II, and 27 in Stage III. Operations were performed on 57 pat...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The German Stomach Cancer TNM Study Group registered 1444 patients from 1982 to 1984 in a multicenter observational study to validate the tumor node metastasis stage groupings. The follow-up-rate in 1989 was 99.4%. Among others the pattern of lymph node metastases and the benefit of systematic lymphadenectomy (SLA) wa...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Accidental ingestion of foreign bodies is a common problem in infants and childhood, but ingestion of magnetic construction toys is very rare. In the case of ingestion of multiple parts of these magnetic construction toys, they may attract each other through the intestinal walls, causing pressure necrosis, perforation...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-0028-1098941
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:We analysed our long-term results with postoperative radiotherapy of the chest wall in male breast cancer patients with respect to local control and survival. METHODS:Twenty-five patients with 26 histological proven carcinomas of the male breast underwent postoperative radiotherapy of the chest wall with ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：10.1055/s-2007-981268
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Complete mesocolic excision (CME) and central vascular ligation (CVL) for right-sided colon cancer may be superior to standard hemicolectomy in terms of oncological results. This hypothesis is currently being investigated in a large multicentre trial conducted by the authors of this paper (Resektatstudie). B...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,多中心研究
doi：10.1055/s-0034-1383133
更新日期：2015-08-01 00:00:00
abstract：:5 patients suffered from melanoblastoma or thyroid cancer were treated with irradiation and cytostatics. The results of spermiograms before, and after treatment show with regard to fertility a moderate prognosis. ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Due to unsatisfactory results of porto-systematic shunts in oesophageal varices as prophylaxis or as therapy in haemorrhagic states local therapeutic measures have attracted attention, especially sclerosing the wall of the oesophagus by an endoscopic technique. ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:This paper gives a short historical overview of the evolution of biliary surgery from John Stough Bobbs (1867) until the present day. The development of different diagnostic methods (from cholangiography to sonography) are described also, as well as the different therapeutic methods including laparoscopic cholecystect...
journal_title：Zentralblatt fur Chirurgie
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:103 cases have been analyzed retrospectively to define the indication for local extirpation of small and deep-seated rectum carcinomas with curative purpose. While pedunculated carcinomatous adenomas can be removed by endoscopic loop extraction, the non-sessile polypous carcinomas have to be radically extirpated by ex...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Hybrid systems with hepatocyte cultures in bioreactors are in development for therapeutical liver assistance. Here, a culture model with a special bioreactor construction was developed: Capillary membrane systems create a three dimensional artificial framework for hepatocyte adhesion, aggregation and reorganization of...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Colorectal cancer (CRC) is the most frequent gastrointestinal tumour. Most CRC appear to arise from adenomas of the colon in a period of 10 or 15 years. The ultimately progression of benign adenomas to malignant CRC is known as the adenoma-carcinoma sequence. In addition, the description of the "serrated pathway" has ...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1328567
更新日期：2015-08-01 00:00:00
abstract：:During the past 10 years, postoperative mortality associated with resection of oesophageal carcinoma has been reduced from 30% to 11%. However, all efforts to improve longterm survival with extensive excisional procedures and adjuvant chemotherapy and radiotherapy have failed. Fifty-three of 100 patients presenting to...
journal_title：Zentralblatt fur Chirurgie
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
