Interethnic variability in birth weight and genetic background: a study of placental alkaline phosphatase.

Abstract:

:The relationship between human placental alkaline phosphatase (PLAP) genotype and birth weight is investigated in a sample of white, black and Puerto-Rican new-born infants from New Haven, Connecticut (total 710 subjects). Black and Puerto-Rican infants show a higher incidence of growth retardation and a higher frequency of ALPp*1/*1 genotype as compared to whites. The proportion of newborns with a low birth weight (below the 10th percentile) is lower in infants with ALPp*1/*1 genotype than in those with other PLAP genotypes, especially among non-whites. It is argued that the higher frequency of ALPp*1 allele among non-whites might be, at least in part, a consequence of their adaptation in the past to environmental conditions adverse to optimal intrauterine development.

journal_name

Am J Phys Anthropol

authors

Amante A,Borgiani P,Gimelfarb A,Gloria-Bottini F

doi

10.1002/(SICI)1096-8644(199612)101:4<449::AID-AJPA

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

449-53

issue

4

eissn

0002-9483

issn

1096-8644

pii

10.1002/(SICI)1096-8644(199612)101:4<449::AID-AJPA

journal_volume

101

pub_type

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