AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

abstract：:All inbred strains of mice carry the Ren-1 structural gene, which encodes the renin-1 isozyme, the classical renin activity found in kidneys. In addition, some strains carry a second renin structural gene, Ren-2, which encodes the predominantly expressed submaxillary gland renin isozyme, renin-2. Ren-1 and Ren-2 exhib...

journal_title：Molecular and cellular biology

authors： Field LJ,Philbrick WM,Howles PN,Dickinson DP,McGowan RA,Gross KW

更新日期：1984-11-01 00:00:00

abstract：:EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However, it remains unclea...

journal_title：Molecular and cellular biology

authors： Li J,Rodriguez Y,Cheng C,Zeng L,Wong EYM,Xu CY,Zhou MM,Xu PX

更新日期：2016-12-19 00:00:00

abstract：:In a previous paper, we have shown that in the absence of stress, mouse embryonal carcinoma cells, like mouse early embryo multipotent cells, synthesize high levels of 89- and 70-kilodalton heat shock proteins (HSP)(O. Bensaude and M. Morange, EMBO J. 2:173-177, 1983). We report here the pattern of proteins synthesize...

journal_title：Molecular and cellular biology

authors： Morange M,Diu A,Bensaude O,Babinet C

更新日期：1984-04-01 00:00:00

abstract：:In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how r...

journal_title：Molecular and cellular biology

authors： Ferris PJ,Vogt VM,Truitt CL

更新日期：1983-04-01 00:00:00

abstract：:Activins and other members of the transforming growth factor beta family play a critical role in morphological changes of the epidermis that require epithelial cell movement. We investigated the molecular pathways in the transmission of activin signals that lead to actin reorganization and epithelial cell migration. W...

journal_title：Molecular and cellular biology

authors： Zhang L,Deng M,Parthasarathy R,Wang L,Mongan M,Molkentin JD,Zheng Y,Xia Y

更新日期：2005-01-01 00:00:00

abstract：:p63 is a member of the p53 tumor suppressor gene family, which regulates downstream target gene expression by binding to sequence-specific response elements similar to those of p53. By using oligonucleotide expression microarray analysis and analyzing the promoters of p63-induced genes, we have identified novel p63-sp...

journal_title：Molecular and cellular biology

authors： Osada M,Park HL,Nagakawa Y,Yamashita K,Fomenkov A,Kim MS,Wu G,Nomoto S,Trink B,Sidransky D

更新日期：2005-07-01 00:00:00

abstract：:The fibroblast integrin alpha11beta1 is a key receptor for fibrillar collagens. To study the potential function of alpha11 in vivo, we generated a null allele of the alpha11 gene. Integrin alpha11(-/-) mice are viable and fertile but display dwarfism with increased mortality, most probably due to severely defective in...

journal_title：Molecular and cellular biology

authors： Popova SN,Barczyk M,Tiger CF,Beertsen W,Zigrino P,Aszodi A,Miosge N,Forsberg E,Gullberg D

更新日期：2007-06-01 00:00:00

abstract：:SWI/SNF ATP-dependent chromatin remodeling complexes (remodelers) perform critical functions in eukaryotic gene expression control. BAP and PBAP are the fly representatives of the two evolutionarily conserved major subclasses of SWI/SNF remodelers. Both complexes share seven core subunits, including the Brahma ATPase,...

journal_title：Molecular and cellular biology

authors： Chalkley GE,Moshkin YM,Langenberg K,Bezstarosti K,Blastyak A,Gyurkovics H,Demmers JA,Verrijzer CP

更新日期：2008-05-01 00:00:00

abstract：:Using nuclear runoff transcription assays we demonstrated that alpha interferon-mediated induction of transcription of four mRNAs in HeLa monolayer cells needed ongoing protein synthesis and that such a need could be obviated by pretreating the cells with gamma interferon which, by itself, did not induce transcription...

journal_title：Molecular and cellular biology

authors： Kusari J,Sen GC

更新日期：1987-01-01 00:00:00

abstract：:Resistance to the growth-inhibitory action of retinoic acid (RA), the bioactive derivative of vitamin A, is common in human tumors. One form of RA resistance has been associated with silencing and hypermethylation of the retinoic acid receptor beta2 gene (RARbeta2), an RA-regulated tumor suppressor gene. The presence ...

journal_title：Molecular and cellular biology

authors： Ren M,Pozzi S,Bistulfi G,Somenzi G,Rossetti S,Sacchi N

更新日期：2005-12-01 00:00:00

abstract：:Extragenic suppressors of a new temperature-sensitive mutation (act1-4) in the actin gene of Saccharomyces cerevisiae were isolated in an attempt to identify genes whose products interact directly with actin. One suppressor with a cold-sensitive growth phenotype defined the new gene, SAC7, which was mapped, cloned, se...

journal_title：Molecular and cellular biology

authors： Dunn TM,Shortle D

更新日期：1990-05-01 00:00:00

abstract：:In the "canonical" view of transforming growth factor beta (TGF-beta) signaling, Smad7 plays an inhibitory role. While Smad7 represses Smad3 activation by TGF-beta, it does not reverse the inhibitory effect of TGF-beta on myogenesis, suggesting a different function in myogenic cells. We previously reported a promyogen...

journal_title：Molecular and cellular biology

authors： Miyake T,Alli NS,McDermott JC

更新日期：2010-02-01 00:00:00

abstract：:Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a role in exocytosis at hair cell ribbon synapses. To date, however, otoferlin has been studied almost exclusively in mouse models, and no rescue ex...

journal_title：Molecular and cellular biology

authors： Chatterjee P,Padmanarayana M,Abdullah N,Holman CL,LaDu J,Tanguay RL,Johnson CP

更新日期：2015-03-01 00:00:00

abstract：:Using an expression cDNA cloning approach, we examined human tumor cell lines for novel oncogenes that might evade detection by conventional techniques. We isolated a transforming sequence that was highly efficient in transforming NIH 3T3 mouse fibroblasts. DNA sequence analysis identified the gene as the human homolo...

journal_title：Molecular and cellular biology

authors： Chan AM,Fleming TP,McGovern ES,Chedid M,Miki T,Aaronson SA

更新日期：1993-02-01 00:00:00

abstract：:X chromosome inactivation silences one of two X chromosomes in the mammalian female cell and is controlled by a binary switch that involves interactions between Xist and Tsix, a sense-antisense pair of noncoding genes. On the future active X chromosome, Tsix expression suppresses Xist upregulation, while on the future...

journal_title：Molecular and cellular biology

authors： Stavropoulos N,Rowntree RK,Lee JT

更新日期：2005-04-01 00:00:00

abstract：:In vitro mutagenesis was used to create putative opal suppressor alleles of a tRNA(Trp) gene of Saccharomyces cerevisiae. The construct with the requisite anticodon change did not result in an active suppressor, whereas when a second change was introduced into the portion of the gene encoding the intron, an active and...

journal_title：Molecular and cellular biology

authors： Atkin AL,Roy KL,Bell JB

更新日期：1990-08-01 00:00:00

abstract：:The Wnt/β-catenin signaling pathway plays crucial roles in early hindbrain formation, and its constitutive activity is associated with a subset of human medulloblastoma, a malignant childhood tumor of the posterior fossa. However, the precise function of Wnt/β-catenin signaling during cerebellar development is still e...

journal_title：Molecular and cellular biology

authors： Lorenz A,Deutschmann M,Ahlfeld J,Prix C,Koch A,Smits R,Fodde R,Kretzschmar HA,Schüller U

更新日期：2011-08-01 00:00:00

abstract：:The human neuroblastoma cell line CHP100 provides a useful model system in which to study the molecular mechanisms of transcriptional regulation of the low-affinity nerve growth factor receptor (NGFR) gene during neuronal development. Basic fibroblast growth factor (bFGF) induced morphological changes in CHP100 cells,...

journal_title：Molecular and cellular biology

authors： Taiji M,Taiji K,Deyerle KL,Bothwell M

更新日期：1992-05-01 00:00:00

abstract：:In order to create an extended map of chromatin features within a mammalian multigene locus, we have determined the extent of nuclease sensitivity and the pattern of histone modifications associated with the mouse beta-globin genes in adult erythroid tissue. We show that the nuclease-sensitive domain encompasses the b...

journal_title：Molecular and cellular biology

authors： Bulger M,Schübeler D,Bender MA,Hamilton J,Farrell CM,Hardison RC,Groudine M

更新日期：2003-08-01 00:00:00

abstract：:To examine the role of simian virus 40 (SV40) large T and small t antigens in tumorigenesis in animals, we generated transgenic mice which expressed either both the SV40 large T and small t antigens or the SV40 large T antigen alone under the control of the mouse mammary tumor virus long terminal repeat. The mouse mam...

journal_title：Molecular and cellular biology

authors： Choi YW,Lee IC,Ross SR

更新日期：1988-08-01 00:00:00

abstract：:R-loops have been described in vivo at the immunoglobulin class switch sequences and at prokaryotic and mitochondrial origins of replication. However, the biochemical mechanism and determinants of R-loop formation are unclear. We find that R-loop formation is nearly eliminated when RNase T(1) is added during transcrip...

journal_title：Molecular and cellular biology

authors： Roy D,Yu K,Lieber MR

更新日期：2008-01-01 00:00:00

abstract：:Members of the cytokine receptor superfamily have structurally similar extracellular ligand-binding domains yet diverse cytoplasmic regions lacking any obvious catalytic domains. Many of these receptors form ligand-induced oligomers which are likely to participate in transmembrane signaling. A constitutively active (f...

journal_title：Molecular and cellular biology

authors： Watowich SS,Hilton DJ,Lodish HF

更新日期：1994-06-01 00:00:00

abstract：:2-Aminopurine (2-AP) inhibits specific kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2. One of these, PKR, is also involved in signal transduction. We show here that 2-AP selectively inhibits expression of tumor necrosis factor alpha (TNF-alpha) mRNA in primary human lymphoid...

journal_title：Molecular and cellular biology

authors： Jarrous N,Osman F,Kaempfer R

更新日期：1996-06-01 00:00:00

abstract：:The mouse urokinase-type plasminogen activator (uPA) gene was used as a model macrophage colony-stimulating factor 1 (CSF-1)-inducible gene to investigate CSF-1 signalling pathways. Nuclear run-on analysis showed that induction of uPA mRNA by CSF-1 and phorbol myristate acetate (PMA) was at the transcriptional level i...

journal_title：Molecular and cellular biology

authors： Stacey KJ,Fowles LF,Colman MS,Ostrowski MC,Hume DA

更新日期：1995-06-01 00:00:00

abstract：:TRF1 is a component of the shelterin complex at mammalian telomeres; however, a role for TRF1 in telomere biology in the context of the organism is unclear. In this study, we generated mice with transgenic TRF1 expression targeted to epithelial tissues (K5TRF1 mice). K5TRF1 mice have shorter telomeres in the epidermis...

journal_title：Molecular and cellular biology

authors： Muñoz P,Blanco R,de Carcer G,Schoeftner S,Benetti R,Flores JM,Malumbres M,Blasco MA

更新日期：2009-03-01 00:00:00

abstract：:DNA sequencing and blot hybridization analyses have been used to study the structure of a mouse VL30 gene and the molecular nature of VL30-related RNA which is induced upon the stimulation of cultured AKR mouse embryo cells with defined peptide growth factors. An integrated mouse VL30 gene was found to contain identic...

journal_title：Molecular and cellular biology

authors： Hodgson CP,Elder PK,Ono T,Foster DN,Getz MJ

更新日期：1983-12-01 00:00:00

abstract：:SEC62 is required for the import of secretory protein precursors into the endoplasmic reticulum (ER) of Saccharomyces cerevisiae. The DNA sequence of SEC62 predicts a 32-kDa polypeptide with two potential membrane-spanning segments. Two antisera directed against different portions of the SEC62 coding region specifical...

journal_title：Molecular and cellular biology

authors： Deshaies RJ,Schekman R

更新日期：1990-11-01 00:00:00

abstract：:To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further a...

journal_title：Molecular and cellular biology

authors： Fassler JS,Winston F

更新日期：1989-12-01 00:00:00

abstract：:The short form (S1b) of the prolactin receptor (PRLR) silences prolactin-induced activation of gene transcription by the PRLR long form (LF). The functional and structural contributions of two intramolecular disulfide (S-S) bonds within the extracellular subdomain 1 (D1) of S1b to its inhibitory function on the LF wer...

journal_title：Molecular and cellular biology

authors： Xie YL,Hassan SA,Qazi AM,Tsai-Morris CH,Dufau ML

更新日期：2009-05-01 00:00:00

abstract：:Nuclear respiratory-defective mutants of Saccharomyces cerevisiae have been screened for lesions in the mitochondrial alpha-ketoglutarate dehydrogenase complex. Strains assigned to complementation group G70 were ascertained to be deficient in enzyme activity due to mutations in the KGD1 gene coding for the alpha-ketog...

journal_title：Molecular and cellular biology

authors： Repetto B,Tzagoloff A

更新日期：1989-06-01 00:00:00