Abstract:
:To examine the role of simian virus 40 (SV40) large T and small t antigens in tumorigenesis in animals, we generated transgenic mice which expressed either both the SV40 large T and small t antigens or the SV40 large T antigen alone under the control of the mouse mammary tumor virus long terminal repeat. The mouse mammary tumor virus long terminal repeat directs the expression of transgenes in ductal epithelial cells of several organs, including the mammary gland, lung, and kidney, and in lymphoid cells. The mice which expressed both the T and t tumor antigens developed lung and kidney adenocarcinomas, while those which expressed large T alone did not. Both types of mice developed malignant lymphomas with similar frequencies and latency periods. Our results show that the SV40 small t antigen cooperates with the large T antigen in inducing tumors in slowly dividing epithelial cells in the lung and kidney.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Choi YW,Lee IC,Ross SRdoi
10.1128/mcb.8.8.3382subject
Has Abstractpub_date
1988-08-01 00:00:00pages
3382-90issue
8eissn
0270-7306issn
1098-5549journal_volume
8pub_type
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pub_type: 杂志文章
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