TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

abstract：:In the yeast Saccharomyces cerevisiae, the CDC25 gene product activates adenylate cyclase through RAS1 and RAS2 gene products. We have recently described the cloning of a DNA fragment which suppresses the cdc25 mutation but not ras1, ras2, or cdc35 mutations. This fragment contains a 5'-truncated open reading frame wh...

journal_title：Molecular and cellular biology

authors： Damak F,Boy-Marcotte E,Le-Roscouet D,Guilbaud R,Jacquet M

更新日期：1991-01-01 00:00:00

abstract：:Myb family proteins are ubiquitously expressed transcription factors. In mammalian cells, they play a critical role in regulating the G(1)/S cell cycle transition but their role in regulating other cell cycle checkpoints is incompletely defined. Herein, we report experiments which demonstrate that c-Myb upregulates cy...

journal_title：Molecular and cellular biology

authors： Nakata Y,Shetzline S,Sakashita C,Kalota A,Rallapalli R,Rudnick SI,Zhang Y,Emerson SG,Gewirtz AM

更新日期：2007-03-01 00:00:00

abstract：:ICP4 of herpes simplex virus is responsible for the activation of viral transcription during infection. It also efficiently activates and represses transcription in vitro depending on the promoter context. The contacts made between ICP4 and the cellular proteins that result in activated transcription have not been ide...

journal_title：Molecular and cellular biology

authors： Carrozza MJ,DeLuca NA

更新日期：1996-06-01 00:00:00

abstract：:rRNA transcription in Xenopus laevis terminates near a 7-base-pair (bp) conserved sequence (T3 box) located 200 bp upstream of the site of transcription initiation for the adjacent gene promoter. We present evidence here that a 12-bp element containing the T3 box is an essential part of the terminator. Using an oocyte...

journal_title：Molecular and cellular biology

authors： Labhart P,Reeder RH

更新日期：1987-05-01 00:00:00

abstract：:Translation initiation plays an important role in cell growth, proliferation, and survival. The translation initiation factor eIF4B (eukaryotic initiation factor 4B) stimulates the RNA helicase activity of eIF4A in unwinding secondary structures in the 5' untranslated region (5'UTR) of the mRNA in vitro. Here, we stud...

journal_title：Molecular and cellular biology

authors： Shahbazian D,Parsyan A,Petroulakis E,Topisirovic I,Martineau Y,Gibbs BF,Svitkin Y,Sonenberg N

更新日期：2010-03-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We have found that the...

journal_title：Molecular and cellular biology

authors： Zhang SQ,Tsiaras WG,Araki T,Wen G,Minichiello L,Klein R,Neel BG

更新日期：2002-06-01 00:00:00

abstract：:Double-stranded RNA (dsRNA) accumulates in virus-infected mammalian cells and signals the activation of host defense pathways of the interferon system. We describe here a novel form of dsRNA-triggered signaling that leads to the stimulation of the p38 mitogen-activated protein kinase (p38 MAPK) and the c-Jun NH(2)-ter...

journal_title：Molecular and cellular biology

authors： Iordanov MS,Paranjape JM,Zhou A,Wong J,Williams BR,Meurs EF,Silverman RH,Magun BE

更新日期：2000-01-01 00:00:00

abstract：:The protein tyrosine kinase c-Src is regulated by two intramolecular interactions. The repressed state is achieved through the interaction of the Src homology 2 (SH2) domain with the phosphorylated C-terminal tail and the association of the SH3 domain with a polyproline type II helix formed by the linker region betwee...

journal_title：Molecular and cellular biology

authors： Adolph D,Flach N,Mueller K,Ostareck DH,Ostareck-Lederer A

更新日期：2007-03-01 00:00:00

abstract：:NF-kappaB activation is reciprocally regulated by RelA/p65 acetylation and deacetylation, which are mediated by histone acetyltransferases (HATs) and deacetylases (HDACs). Here we demonstrate that in leukemia cells, NF-kappaB activation by the HDAC inhibitors (HDACIs) MS-275 and suberoylanilide hydroxamic acid was ass...

journal_title：Molecular and cellular biology

authors： Dai Y,Rahmani M,Dent P,Grant S

更新日期：2005-07-01 00:00:00

abstract：:To understand how DEXD/H-box proteins recognize and interact with their cellular substrates, we have been studying Prp28p, a DEXD/H-box splicing factor required for switching the U1 snRNP with the U6 snRNP at the precursor mRNA (pre-mRNA) 5' splice site. We previously demonstrated that the requirement for Prp28p can b...

journal_title：Molecular and cellular biology

authors： Hage R,Tung L,Du H,Stands L,Rosbash M,Chang TH

更新日期：2009-07-01 00:00:00

abstract：:Genomic imprinting results in parent-of-origin-dependent monoallelic expression of selected genes. Although their importance in development and physiology is recognized, few imprinted genes have been investigated for their effects on brain function. Gnas is a complex imprinted locus whose gene products are involved in...

journal_title：Molecular and cellular biology

authors： Plagge A,Isles AR,Gordon E,Humby T,Dean W,Gritsch S,Fischer-Colbrie R,Wilkinson LS,Kelsey G

更新日期：2005-04-01 00:00:00

abstract：:The cellular mechanisms involved in chronic inflammatory processes are poorly understood. This is especially true for the role of macrophages, which figure prominently in the inflammatory response. Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in norm...

journal_title：Molecular and cellular biology

authors： Lagasse E,Clerc RG

更新日期：1988-06-01 00:00:00

abstract：:We determined the sequence of a Drosophila tRNA gene cluster containing a tRNAHis gene and a tRNAHis pseudogene in close proximity on the same DNA strand. The pseudogene contains eight consecutive base pairs different from the region of the bona fide gene which codes for the 3' portion of the anticodon stem of tRNAHis...

journal_title：Molecular and cellular biology

authors： Cooley L,Schaack J,Burke DJ,Thomas B,Söll D

更新日期：1984-12-01 00:00:00

abstract：:Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), a Drosophila segmentation gene of the gap class. We have used the GLI cDNA as a molecular probe to isolate related sequence...

journal_title：Molecular and cellular biology

authors： Ruppert JM,Kinzler KW,Wong AJ,Bigner SH,Kao FT,Law ML,Seuanez HN,O'Brien SJ,Vogelstein B

更新日期：1988-08-01 00:00:00

abstract：:We have characterized a cDNA encoding a cysteine-rich, acidic integral membrane protein (CRAM) of the parasitic protozoa Trypanosoma brucei and Trypanosoma equiperdum. Unlike other membrane proteins of T. brucei, which are distributed throughout the cell surface, CRAM is concentrated in the flagellar pocket, an invagi...

journal_title：Molecular and cellular biology

authors： Lee MG,Bihain BE,Russell DG,Deckelbaum RJ,Van der Ploeg LH

更新日期：1990-09-01 00:00:00

abstract：:Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany g...

journal_title：Molecular and cellular biology

authors： Sutcliffe EL,Parish IA,He YQ,Juelich T,Tierney ML,Rangasamy D,Milburn PJ,Parish CR,Tremethick DJ,Rao S

更新日期：2009-04-01 00:00:00

abstract：:We have analyzed the 5'-flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA). To analyze this observation further, we placed a 265-base-pair 5'...

journal_title：Molecular and cellular biology

authors： Edbrooke MR,Burt DW,Cheshire JK,Woo P

更新日期：1989-05-01 00:00:00

abstract：:Alternative splicing of the locus AbetaH-J-J generates three functionally distinct proteins: an enzyme, AbetaH (aspartyl-beta-hydroxylase), a structural protein of the sarcoplasmic reticulum membrane (junctin), and an integral membrane calcium binding protein (junctate). Junctin and junctate are two important proteins...

journal_title：Molecular and cellular biology

authors： Feriotto G,Finotti A,Volpe P,Treves S,Ferrari S,Angelelli C,Zorzato F,Gambari R

更新日期：2005-04-01 00:00:00

abstract：:Transcription of the Drosophila homologs of the abl and src cellular oncogenes, termed Dash and Dsrc , respectively, was studied. Despite the fact that Dash and Dsrc share sequence homology, they have distinct patterns of transcription during development. The Dash transcript, 6.2 kilobases long, is found in maternal R...

journal_title：Molecular and cellular biology

authors： Lev Z,Leibovitz N,Segev O,Shilo BZ

更新日期：1984-05-01 00:00:00

abstract：:Spatial control of cytokinesis is essential for proper cell division. The molecular mechanisms that anchor the dynamic assembly and constriction of the cytokinetic ring at the plasma membrane remain unclear. In the fission yeast Schizosaccharomyces pombe, the cytokinetic ring is assembled in the cell middle from corti...

journal_title：Molecular and cellular biology

authors： Guzman-Vendrell M,Baldissard S,Almonacid M,Mayeux A,Paoletti A,Moseley JB

更新日期：2013-01-01 00:00:00

abstract：:DHTKD1, a part of 2-ketoadipic acid dehydrogenase complex, is involved in lysine and tryptophan catabolism. Mutations in DHTKD1 block the metabolic pathway and cause 2-aminoadipic and 2-oxoadipic aciduria (AMOXAD), an autosomal recessive inborn metabolic disorder. In addition, a nonsense mutation in DHTKD1 that we ide...

journal_title：Molecular and cellular biology

authors： Xu WY,Zhu H,Shen Y,Wan YH,Tu XD,Wu WT,Tang L,Zhang HX,Lu SY,Jin XL,Fei J,Wang ZG

更新日期：2018-06-14 00:00:00

abstract：:In this report, we demonstrate that myogenic cultures inhibited from differentiating by treatment with fibroblast growth factor or transforming growth factor beta show reduced levels of MyoD1 mRNA. Although this repression may contribute to the inhibition of myogenesis by growth factors, additional regulatory pathways...

journal_title：Molecular and cellular biology

authors： Vaidya TB,Rhodes SJ,Taparowsky EJ,Konieczny SF

更新日期：1989-08-01 00:00:00

abstract：:Cell numbers are regulated by a balance among proliferation, growth arrest, and programmed cell death. A profound example of cell homeostasis, controlled throughout life, is the complex process of blood cell development, yet little is understood about the intracellular mechanisms that regulate blood cell growth arrest...

journal_title：Molecular and cellular biology

authors： Selvakumaran M,Lin HK,Sjin RT,Reed JC,Liebermann DA,Hoffman B

更新日期：1994-04-01 00:00:00

abstract：:Monoclonal antibodies to fibrillin 1 (MP340), a component of elastin-associated microfibrils, were used to screen cDNA libraries made from bovine nuchal ligament mRNA. One of the selected clones (cL9; 1.2 kb) hybridized on Northern (RNA) blotting with nuchal ligament mRNA to two abundant mRNAs of 9.0 and 7.5 kb, which...

journal_title：Molecular and cellular biology

authors： Gibson MA,Hatzinikolas G,Davis EC,Baker E,Sutherland GR,Mecham RP

更新日期：1995-12-01 00:00:00

abstract：:The highly conserved SR family contains a growing number of phosphoproteins acting as both essential and alternative splicing factors. In this study, we have cloned human genomic and cDNA sequences encoding a novel SR protein designated SRp46. Nucleotide sequence analyses have revealed that the SRp46 gene corresponds ...

journal_title：Molecular and cellular biology

authors： Soret J,Gattoni R,Guyon C,Sureau A,Popielarz M,Le Rouzic E,Dumon S,Apiou F,Dutrillaux B,Voss H,Ansorge W,Stévenin J,Perbal B

更新日期：1998-08-01 00:00:00

abstract：:Human MED26 was originally purified in the cofactor required for the Sp1 activation complex (CRSP) as a 70-kDa component named CRSP70. This polypeptide was specific to metazoans and the “small” form of the Mediator complex. We report here that a Drosophila melanogaster homologue of MED26 similarly interacts with other...

journal_title：Molecular and cellular biology

authors： Marr SK,Lis JT,Treisman JE,Marr MT 2nd

更新日期：2014-07-01 00:00:00

abstract：:The FLP protein of the Saccharomyces cerevisiae plasmid 2 microns circle catalyzes site-specific recombination between two repeated segments present on the plasmid. In this paper we present results of experiments we performed to define more precisely the features of the FLP recognition target site, which we propose to...

journal_title：Molecular and cellular biology

authors： McLeod M,Craft S,Broach JR

更新日期：1986-10-01 00:00:00

abstract：:We analyzed the Burkitt's lymphoma line BL64 in which a reciprocal translocation joins the immunoglobulin kappa light-chain locus on chromosome 2 to the c-myc gene on chromosome 8. The breakpoints on the two marker chromosomes 8+ and 2p- occurred 5' of the Js segment within the conserved nonamer and heptamer recombina...

journal_title：Molecular and cellular biology

authors： Hartl P,Lipp M

更新日期：1987-06-01 00:00:00

abstract：:In Saccharomyces cerevisiae, transcriptional activation mediated by the GAL4 regulatory protein is repressed in the absence of galactose by the binding of the GAL80 protein, an interaction that requires the carboxy-terminal 28 amino acids of GAL4. The homolog of GAL4 from Kluyveromyces lactis, LAC9, activates transcri...

journal_title：Molecular and cellular biology

authors： Salmeron JM Jr,Langdon SD,Johnston SA

更新日期：1989-07-01 00:00:00

abstract：:The rapid nuclear translocation of signaling proteins upon stimulation is important for the regulation of de novo gene expression. We have studied the stimulated nuclear shuttling of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs) and found that they translocate into the nucleus in a Ra...

journal_title：Molecular and cellular biology

authors： Zehorai E,Seger R

更新日期：2014-01-01 00:00:00