Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal alpha-actin promoter, and the immunoglobulin heavy-chain enhancer.


:Ubiquitously expressed transcription factors play an integral role in establishing and regulating patterns of gene transcription. Common factor 1 (CF1) is a ubiquitously expressed DNA-binding protein previously identified in our laboratory. We show here that CF1 recognizes sites in several diverse transcription elements, and we demonstrate the ability of the c-myc CF1 site to activate transcription of a basal promoter in both B cells and fibroblasts.


Mol Cell Biol


Riggs KJ,Merrell KT,Wilson G,Calame K




Has Abstract


1991-03-01 00:00:00












  • The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.

    abstract::The tetraspanins are a family of integral membrane proteins with four transmembrane domains. These molecules form multimolecular networks on the surfaces of many different cell types. Gene-targeting studies have revealed a role for tetraspanins in B- and T-lymphocyte function. We have isolated and deleted a novel tetr...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Tarrant JM,Groom J,Metcalf D,Li R,Borobokas B,Wright MD,Tarlinton D,Robb L

    更新日期:2002-07-01 00:00:00

  • Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae.

    abstract::Aromatic aminotransferase II, product of the ARO9 gene, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism in Saccharomyces cerevisiae. ARO9 expression is under the dual control of specific induction and nitrogen source regulation. We have here identified UASaro, a 36-bp upstream element ne...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Iraqui I,Vissers S,André B,Urrestarazu A

    更新日期:1999-05-01 00:00:00

  • P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia.

    abstract::Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release or leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for microglial chemotaxis and P2Y6 receptors as mediators for phagocytosis. However, pino...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Li HQ,Chen C,Dou Y,Wu HJ,Liu YJ,Lou HF,Zhang JM,Li XM,Wang H,Duan S

    更新日期:2013-11-01 00:00:00

  • Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.

    abstract::The chaperone-related AAA ATPase Cdc48 (p97/VCP in higher eukaryotes) segregates ubiquitylated proteins for subsequent degradation by the 26S proteasome or for nonproteolytic fates. The specific outcome of Cdc48 activity is controlled by the evolutionary conserved cofactors Ufd2 and Ufd3, which antagonistically regula...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Böhm S,Lamberti G,Fernández-Sáiz V,Stapf C,Buchberger A

    更新日期:2011-04-01 00:00:00

  • Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes.

    abstract::A transcriptional enhancer has been mapped to a region 5.5 kilobases 3' of the C beta 2 gene in the human T-cell receptor (TCR) beta-chain locus. Transient transfections allowed localization of enhancer activity to a 480-base-pair HincII-XbaI restriction enzyme fragment. The TCR beta enhancer was active on both the mi...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Gottschalk LR,Leiden JM

    更新日期:1990-10-01 00:00:00

  • Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.

    abstract::The Wnt signaling pathway plays a pivotal role in vertebrate early development and morphogenesis. Duplin (axis duplication inhibitor) interacts with beta-catenin and prevents its binding to Tcf, thereby inhibiting downstream Wnt signaling. Here we show that Duplin is expressed predominantly from early- to mid-stage mo...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Nishiyama M,Nakayama K,Tsunematsu R,Tsukiyama T,Kikuchi A,Nakayama KI

    更新日期:2004-10-01 00:00:00

  • Recognition of RNA editing sites is directed by unique proteins in chloroplasts: biochemical identification of cis-acting elements and trans-acting factors involved in RNA editing in tobacco and pea chloroplasts.

    abstract::RNA editing in higher-plant chloroplasts involves C-to-U conversions at specific sites. Although in vivo analyses have been performed, little is known about the biochemical aspects of chloroplast editing reactions. Here we improved our original in vitro system and devised a procedure for preparing active chloroplast e...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Miyamoto T,Obokata J,Sugiura M

    更新日期:2002-10-01 00:00:00

  • Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.

    abstract::Ribonucleotide reductase (RNR), which catalyzes the rate-limiting step for deoxyribonucleotide production required for DNA synthesis, is an alpha2beta2 tetramer consisting of two large and two small subunits. RNR2 encodes a small subunit and is essential for mitotic viability in Saccharomyces cerevisiae. We have clone...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Huang M,Elledge SJ

    更新日期:1997-10-01 00:00:00

  • Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

    abstract::PC12 cells treated with nerve growth factor (NGF) or infected with Rous sarcoma virus differentiate into sympathetic, neuronlike cells. To compare the differentiation programs induced by NGF and v-src, we have established a PC12 cell line expressing a temperature-sensitive v-src protein. The v-src-expressing PC12 cell...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Thomas SM,Hayes M,D'Arcangelo G,Armstrong RC,Meyer BE,Zilberstein A,Brugge JS,Halegoua S

    更新日期:1991-09-01 00:00:00

  • Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.

    abstract::The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is inactivated by phosphorylation upon growth factor stimulation of quiescent cells, facilitating the transition from G(1) phase to S phase. ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Dasgupta P,Sun J,Wang S,Fusaro G,Betts V,Padmanabhan J,Sebti SM,Chellappan SP

    更新日期:2004-11-01 00:00:00

  • Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.

    abstract::Although the essential involvement of the progesterone receptor (PR) in female reproductive tissues is firmly established, the coregulators preferentially enlisted by PR to mediate its physiological effects have yet to be fully delineated. To further dissect the roles of members of the steroid receptor coactivator (SR...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mukherjee A,Soyal SM,Fernandez-Valdivia R,Gehin M,Chambon P,Demayo FJ,Lydon JP,O'Malley BW

    更新日期:2006-09-01 00:00:00

  • Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.

    abstract::The lactogenic hormones, i.e., prolactin and glucocorticoids, act in concert to stimulate transcription factors responsible for hormone-dependent milk protein gene expression. In the mammary gland, prolactin activates Stat5a and Stat5b and glucocorticoids activate the glucocorticoid receptor (GR). Immunoprecipitation ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Cella N,Groner B,Hynes NE

    更新日期:1998-04-01 00:00:00

  • Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.

    abstract::The histone H1(0)-encoding gene is expressed in vertebrates in differentiating cells during the arrest of proliferation. In the H1(0) promoter, a specific regulatory element, which we named the H4 box, exhibits features which implicate a role in mediating H1(0) gene expression in response to both differentiation and c...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Lemercier C,Duncliffe K,Boibessot I,Zhang H,Verdel A,Angelov D,Khochbin S

    更新日期:2000-09-01 00:00:00

  • Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.

    abstract::Thyroid hormone (T3) is critical for growth, differentiation, and maintenance of metabolic homeostasis. Mice with a knock-in mutation in the thyroid hormone receptor alpha gene (TRalpha1PV) were created previously to explore the roles of mutated TRalpha1 in vivo. TRalpha1PV is a dominant negative mutant with a framesh...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ying H,Araki O,Furuya F,Kato Y,Cheng SY

    更新日期:2007-03-01 00:00:00

  • Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

    abstract::To examine a role for focal adhesion kinase (FAK) in cardiac morphogenesis, we generated a line of mice with a conditional deletion of FAK in nkx2-5-expressing cells (herein termed FAKnk mice). FAKnk mice died shortly after birth, likely resulting from a profound subaortic ventricular septal defect and associated mala...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hakim ZS,DiMichele LA,Doherty JT,Homeister JW,Beggs HE,Reichardt LF,Schwartz RJ,Brackhan J,Smithies O,Mack CP,Taylor JM

    更新日期:2007-08-01 00:00:00

  • Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types.

    abstract::In mammals, the gene coding for apolipoprotein AI (apoAI), a protein of the plasma lipid transport system, is expressed only in the liver and the intestine. A series of plasmids containing various lengths of sequences flanking the 5' end of the human apoAI gene were constructed and assayed for transient expression aft...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Sastry KN,Seedorf U,Karathanasis SK

    更新日期:1988-02-01 00:00:00

  • Two upstream activation sequences control the expression of the XPR2 gene in the yeast Yarrowia lipolytica.

    abstract::We have initiated a study of the promoter region of the alkaline extracellular protease gene (XPR2) from Yarrowia lipolytica to identify upstream sequences possibly involved in carbon, nitrogen, and peptone control of XPR2 expression. Deletion analysis showed that the TATA box and two major upstream activation sequenc...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Blanchin-Roland S,Cordero Otero RR,Gaillardin C

    更新日期:1994-01-01 00:00:00

  • Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes.

    abstract::Nonhistone chromosomal proteins HMG-14 and HMG-17 are closely related nucleosomal binding proteins that unfold the higher-order chromatin structure, thereby enhancing the transcription and replication potential of chromatin. Here we report that PCAF, a transcription coactivator with intrinsic histone acetyltransferase...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Herrera JE,Sakaguchi K,Bergel M,Trieschmann L,Nakatani Y,Bustin M

    更新日期:1999-05-01 00:00:00

  • AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.

    abstract::The G protein-coupled alpha-factor receptor promotes polarized growth toward a mating partner. alpha-Factor induces the expression of AFR1, which acts together with the receptor C terminus to promote normal morphogenesis. The function of AFR1 was investigated by engineering cells to constitutively express AFR1 without...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Konopka JB,DeMattei C,Davis C

    更新日期:1995-02-01 00:00:00

  • pp60c-src in the developing cerebellum.

    abstract::pp60c-src was localized in the cerebellum of developing chicken embryos by immunoperoxidase staining with antisera raised against bacterially expressed pp60v-src. Immunoreactivity (IR) appeared in the cerebellum of the chicken embryos at the time of neuronal differentiation. pp60c-src IR was detected in regions of the...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Fults DW,Towle AC,Lauder JM,Maness PF

    更新日期:1985-01-01 00:00:00

  • axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

    abstract::Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming gene from the DNA of two patients with chronic myelogenous leukemia. Sequence analysis indicates that the product of this gene, axl, is a receptor tyrosine kinase. Overexpression of axl cDNA in NIH 3T3 cells induces neoplastic t...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: O'Bryan JP,Frye RA,Cogswell PC,Neubauer A,Kitch B,Prokop C,Espinosa R 3rd,Le Beau MM,Earp HS,Liu ET

    更新日期:1991-10-01 00:00:00

  • Histone occupancy in vivo at the 601 nucleosome binding element is determined by transcriptional history.

    abstract::We report in vivo analysis of histone and RNA polymerase II (pol II) occupancy at the 601 element, which functions as a strong in vitro nucleosome-positioning element and transcriptional pause site. Surprisingly, nucleosomes were not strongly positioned over the 601 element inserted either within a yeast chromosomal o...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Perales R,Zhang L,Bentley D

    更新日期:2011-08-01 00:00:00

  • Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration.

    abstract::CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycosylated CD133. The l...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Yang F,Xing Y,Li Y,Chen X,Jiang J,Ai Z,Wei Y

    更新日期:2018-07-16 00:00:00

  • LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence.

    abstract::LEU3 of Saccharomyces cerevisiae encodes an 886-amino-acid polypeptide that regulates transcription of a group of genes involved in leucine biosynthesis and has been shown to bind specifically to a 114-base-pair DNA fragment of the LEU2 upstream region (P. Friden and P. Schimmel, Mol. Cell. Biol. 7:2707-2717, 1987). W...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Friden P,Schimmel P

    更新日期:1988-07-01 00:00:00

  • Sequence organization and RNA structural motifs directing the mouse primary rRNA-processing event.

    abstract::The first processing step in the maturation of mouse precursor rRNA involves cleavage at nucleotide ca. +650, at the 5' border of a 200-nucleotide region that is conserved across mammals and contains the sequences that direct the processing. To identify the relevant sequence elements, we used rRNAs with small internal...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Craig N,Kass S,Sollner-Webb B

    更新日期:1991-01-01 00:00:00

  • HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.

    abstract::Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling events that regulate the successive steps of vascular development are known in some detail, the transcriptional processes that regulate the first steps in vasculogenesis are ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Wu Y,Moser M,Bautch VL,Patterson C

    更新日期:2003-08-01 00:00:00

  • Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.

    abstract::The c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) is activated in response to the treatment of cells with inflammatory cytokines and by exposure to environmental stress. JNK activation is mediated by a protein kinase cascade composed of a MAPK kinase and a MAPK kinase kinase. Her...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Kelkar N,Gupta S,Dickens M,Davis RJ

    更新日期:2000-02-01 00:00:00

  • Excision repair functions in Saccharomyces cerevisiae recognize and repair methylation of adenine by the Escherichia coli dam gene.

    abstract::Unlike the DNA of higher eucaryotes, the DNA of Saccharomyces cerevisiae (bakers' yeast) is not methylated. Introduction of the Escherichia coli dam gene into yeast cells results in methylation of the N-6 position of adenine. The UV excision repair system of yeast cells specifically responds to the methylation, sugges...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hoekstra MF,Malone RE

    更新日期:1986-10-01 00:00:00

  • Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors.

    abstract::Retinoblastoma (RB) tumors develop when both alleles of a gene (RB1) are mutated and unable to function normally. Recently, Friend et al. [S. H. Friend, R. Bernards, S. Rogelj, R. A. Weinberg, J. M. Rapaport, D. M. Albert, and T. P. Dryja, Nature (London) 32:643-646, 1986] reported the cloning of a gene, 4.7R, with so...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Goddard AD,Balakier H,Canton M,Dunn J,Squire J,Reyes E,Becker A,Phillips RA,Gallie BL

    更新日期:1988-05-01 00:00:00

  • Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast.

    abstract::Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the roles of Spt6, we performed genome-wide analyses of transcription, chromatin structure, and histone modifications in a Schizosaccharomy...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: DeGennaro CM,Alver BH,Marguerat S,Stepanova E,Davis CP,Bähler J,Park PJ,Winston F

    更新日期:2013-12-01 00:00:00