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Blood-ocular barrier damage: use of contrast-enhanced MRI.

Abstract：

:The blood-ocular barrier (BOB) shares similar neuroepithelial origin, microanatomy and functions with the blood-brain barrier. There are many natural (e. g. diabetes, hypertension) or iatrogenic (chemotherapy, retinal photocoagulation) conditions which can cause a BOB breakdown, resulting in visual acuity impairment or loss. The authors examined 42 patients affected by BOB damage in different pathological conditions. All patients previously underwent a conventional fluoroangiographic (FA) study. Nine patients with normal FA exam were evaluated also. Despite normal MRI findings immediately after Gd-DTPA injection, contrast leakage into the vitreous body or into the aqueous fluid was demonstrated in delayed scans (40-50 min after contrast administration), proving the existence of a BOB damage (sensitively 94 %). Although FA exam remains the choice modality in BOB breakdown demonstration, we propose MRI as a useful diagnostic tool when optic media opacity (cataract, haemovitreous, intraocular silicon oil) occurs, preventing direct retinal fundus imaging and/or an early screening tool.

journal_name

Eur Radiol

journal_title

European radiology

authors

Manfré L,Midiri M,Giuffré G,Mangiameli A,Cardella G,Ponte F,De Maria M,Lagalla R

doi

10.1007/s003300050121

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

110-4

issue

1

eissn

0938-7994

issn

1432-1084

journal_volume

7

pub_type

杂志文章

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