Abstract:
OBJECTIVES:To evaluate the MRI macroscopic and microscopic parameters of mesorectal vasculature in rectal cancer patients. METHODS:Thirteen patients with rectal adenocarcinoma underwent a dynamic contrast-enhanced MRI at 1.5 T using a blood pool agent at the primary staging. Mesorectal macrovascular features, i.e., the number of vascular branches, average diameter and length, were assessed from baseline-subtracted post-contrast images by two independent readers. Mesorectal microvascular function was investigated by means of area under the enhancement-time curve (AUC). Histopathology served as reference standard of the tumour response to CRT. RESULTS:The average vessel branching in the mesorectum around the tumour and normal rectal wall was 8.2 ± 3.8 and 1.7 ± 1.3, respectively (reader1: p = 0.001, reader2: p = 0.002). Similarly, the tumour-surrounding mesorectum displayed circa tenfold elevated AUC (p = 0.01). Interestingly, patients with primary node involvement had a twofold higher number of macrovascular branches compared to those with healthy nodes (reader1: p = 0.005 and reader2: p = 0.03). A similar difference was observed between good and poor responders to CRT, whose tumour-surrounding mesorectum displayed 10.7 ± 3.4 and 5.6 ± 1.5 vessels, respectively (reader1/reader2: p = 0.02). CONCLUSIONS:We showed at baseline MRI of rectal tumours a significantly enhanced macrovascular structure and microvascular function in rectal tumour-surrounding mesorectum, and the association of primary mesorectal macrovascular parameters with node involvement and therapy response. KEY POINTS:• Vascular MRI reveals macrovascular and microvascular abnormalities in the rectal tumour-surrounding mesorectum. • Formation of highly vascular stroma precedes the actual tumour invasion. • High macrovascular parameters are associated with node involvement. • Mesorectal vascular network differs for good and poor responders.
journal_name
Eur Radioljournal_title
European radiologyauthors
Kluza E,Kleijnen JP,Martens MH,Rennspiess D,Maas M,Jeukens CR,Riedl RG,zur Hausen A,Beets GL,Beets-Tan RGdoi
10.1007/s00330-015-3955-1subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1311-9issue
5eissn
0938-7994issn
1432-1084pii
10.1007/s00330-015-3955-1journal_volume
26pub_type
杂志文章abstract::We present a case of swelling of the eyelid and supraorbital anesthesia caused by an intraorbital tumor. The differential diagnosis based on imaging consisted of aneurysmal bone cyst, schwannoma, neurofibroma, dermoid cyst, and cavernous hemangioma. The surgical and pathological diagnosis was an ancient schwannoma of ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1659-0
更新日期:2010-09-01 00:00:00
abstract::The spectrum of radiographic findings in pulmonary infections due to M. tuberculosis (TB) and non-tuberculous mycobacteria (NTM) are being increasingly discussed, primarily as a result of the increasing prevalence of these infections. The NTM organisms are often overlooked as potential infecting organisms, diagnosis i...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-2042-1
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To compare two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) measurements of ablation zones (AZs) related to the shaft of two different large-volume monopolar multi-tined expandable electrodes. METHODS:Percutaneous radiofrequency (RF) ablation was performed in 12 pigs (81.6 +/- 7.8 kg...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1639-4
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abstract:OBJECTIVES:The clinical presentation of peripheral artery disease (PAD) and chronic venous insufficiency (CVI) can overlap and the conditions may co-exist. The purpose of our study was to investigate the prevalence and clinical significance of concomitant CVI in patients with PAD examined with run-off MR angiography (M...
journal_title:European radiology
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abstract::Surrogate markers and biomarkers based on imaging readouts providing predictive information on clinical outcome are of increasing importance in the preclinical and clinical evaluation of novel therapies. They are primarily used in studies designed to establish evidence that the therapeutic principle is valid in a repr...
journal_title:European radiology
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doi:10.1007/s00330-007-0619-9
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abstract:OBJECTIVES:Radio frequency (RF) pulses in magnetic resonance imaging (MRI) can interact with implanted devices and cause tissue damage. However, there are new devices that can safely perform measurements with liberal MRI conditions such as an RF transmission field B1+rms ≤ 2.0 μT. We investigated whether MRI in this ca...
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abstract::Magnetic resonance (MR) arthrography has gained increasing popularity as a diagnostic tool in the assessment of intra-articular derangements. Its role has been studied extensively in the shoulder, but it also has been explored in the hip, elbow, knee, wrist and ankle. This article reviews the current role of direct MR...
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pub_type: 杂志文章,评审
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abstract:UNLABELLED:This paper summarizes information about breast MRI to be provided to women and referring physicians. After listing contraindications, procedure details are described, stressing the need for correct scheduling and not moving during the examination. The structured report including BI-RADS® categories and furth...
journal_title:European radiology
pub_type: 杂志文章,评审
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journal_title:European radiology
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journal_title:European radiology
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pub_type: 杂志文章,多中心研究
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更新日期:2000-01-01 00:00:00
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journal_title:European radiology
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journal_title:European radiology
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abstract::Whole-body MRI (WB-MRI) has been successfully applied for oncologic and cardiovascular diagnostics, whereas imaging in myopathies usually employs dedicated protocols restricted to areas of specific interest. In this study, we propose a comprehensive neuromuscular WB-MRI protocol. Eighteen patients with degenerative an...
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