Abstract：
:The rapidity with which heparin anticoagulation is achieved is essential to a positive clinical outcome in patients with deep venous thrombosis or pulmonary embolus. However, adequate anticoagulation is frequently not achieved, either as a result of dosing regimens that do not take heparin kinetics into account or because of clinicians' wariness of possible hemorrhagic complications associated with elevated activated activated partial thromboplastin times. Obese patients are at particularly greater risk for subtherapeutic heparin dosing because their pharmacokinetic volumes of distribution differ from those in nonobese patients. Traditional empiric heparin dosing schemes may have pitfalls; methods that take into account the patient's weight are more likely to allow rapid anticoagulation. A nomogram that uses pharmacokinetic and volume of distribution principles to predict therapeutic levels of anticoagulation is presented.
journal_name
Am Fam Physicianjournal_title
American family physicianauthors
Schaefer DC,Hufnagle J,Williams Lsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
2517-21issue
8eissn
0002-838Xissn
1532-0650journal_volume
54pub_type
杂志文章,评审abstract：:Minor neurologic signs or transient ischemic attacks (TIAs) precede stroke in 50 percent of patients. In men, antiplatelet therapy decreases the risk of recurrent TIA and stroke. Carotid endarterectomy for TIA is now one of the most commonly performed vascular operations. Preoperatively, the arterial anatomy of the pa...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:Worry is a normal response to uncertainty. Education, empathetic support, reassurance, and passage of time usually ameliorate ordinary worries. However, these common-sense strategies for dealing with transient worries often prove ineffective for patients with excessive worry, many of whom meet the criteria for disorde...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-15 00:00:00
abstract：:Exercise-induced bronchoconstriction describes the narrowing of the airway that occurs with exercise. More than 10 percent of the general population and up to 90 percent of persons previously diagnosed with asthma have exercise-induced bronchoconstriction. Common symptoms include coughing, wheezing, and chest tightnes...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2011-08-15 00:00:00
abstract：:Hyperparathyroidism is a common cause of hypercalcemia. The hypercalcemia usually is discovered during a routine serum chemistry profile. Often, there has been no previous suspicion of this disorder. In most patients initially believed to be asymptomatic, previously unrecognized symptoms resolve with surgical correcti...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1998-04-15 00:00:00
abstract：:Infectious endocarditis results from bacterial or fungal infection of the endocardial surface of the heart and is associated with significant morbidity and mortality. Risk factors include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of inv...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2012-05-15 00:00:00
abstract：:Postpartum hemorrhage, the loss of more than 500 mL of blood after delivery, occurs in up to 18 percent of births and is the most common maternal morbidity in developed countries. Although risk factors and preventive strategies are dearly documented, not all cases are expected or avoidable. Uterine atony is responsibl...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2007-03-15 00:00:00
abstract：:Multiple sclerosis, an idiopathic inflammatory disease of the central nervous system, is characterized pathologically by demyelination and subsequent axonal degeneration. The disease commonly presents in young adults and affects twice as many women as men. Common presenting symptoms include numbness, weakness, visual ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-15 00:00:00
abstract：:Hoarseness is the term often used by patients to describe changes in their voice quality. The causes of hoarseness are determined after obtaining a detailed medical history of the circumstances preceding the onset of hoarseness and performing a thorough physical examination. The latter may include visualization of the...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：:Sudden cardiac death is a major public health problem, affecting 500,000 patients in the United States annually. An implantable cardioverter-defibrillator (ICD) can terminate malignant ventricular arrhythmias and has been shown to improve survival in high-risk populations. Although sudden cardiac death is a heterogene...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：:Physicians can create their own personal formulary by rigorously selecting and regularly using one or two drugs for each clinical condition they commonly encounter. The primary and secondary medical literature provides the necessary information to create this formulary. Primary literature sources include peer-reviewed...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:Growth plate or physeal injuries are classified according to the zones of the physis that are affected and the disruption of bony structure. All physeal injuries should be reduced anatomically, particularly when an articular surface is involved. Inability to restore normal configuration can result in malunion, incongr...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:Ginger (Zingiber officinale) is one of the more commonly used herbal supplements. Although often consumed for culinary purposes, it is taken by many patients to treat a variety of conditions. Ginger has been shown to be effective for pregnancy-induced and postoperative nausea and vomiting. There is less evidence to su...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:Apophyseal injuries, which are unique in the adolescent athlete, cause inflammation at the site of a major tendinous insertion onto a growing bony prominence. These injuries typically occur in active adolescents between the ages of eight and 15 years and usually present as periarticular pain associated with growth, sk...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:The classic chest radiograph, showing bilateral hilar and right paratracheal adenopathy, is found in half of sarcoidosis patients. Pulmonary infiltrates are a major cause of morbidity and mortality. Extrapulmonary disease may be found in the skin, eyes, liver and heart, and in the nervous, musculoskeletal and other sy...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1988-08-01 00:00:00
abstract：:Outpatient intravenous antibiotic therapy is a cost-effective modality to shorten hospital stays and provide continued care to patients with infections. The recent availability of tamper-proof pumps that can deliver multiple antibiotics on independently timed regimens will further expand the use of home intravenous an...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Colonic angiodysplasia is now recognized as a frequent cause of gastrointestinal bleeding in patients over age 55. These microvascular arteriovenous malformations may be as common a cause of colonic bleeding as diverticular disease. The lesions are not evident on barium studies. Even colonoscopy and selective colonic ...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:Henoch-Schönlein purpura is an acute, systemic, immune complex-mediated, leukocytoclastic vasculitis. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain, and arthritis. Most patients have an antecedent upper respiratory illness. More than 90 percent of Henoch-Schönlein purpur...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：:The U.S. Preventive Services Task Force recommends that clinicians screen adults for alcohol misuse and provide persons engaged in risky or hazardous drinking behaviors with brief behavioral counseling to reduce alcohol misuse. However, only a minority of American adults with high-risk alcohol use receive treatment. T...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2016-03-15 00:00:00
abstract：:Abdominal aortic aneurysms occur in 5 to 7 percent of people over age 60 in the United States. An aneurysm is defined as a permanent localized dilatation of an artery, with an increase in diameter of greater than 1.5 times its normal diameter. Abdominal aortic aneurysms may be manifested by catastrophic rupture, signs...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-15 00:00:00
abstract：:The best condoms are made of latex, are lubricated and coated with a spermicide, and have a reservoir tip. Condoms can protect against conception and sexually transmitted diseases, including acquired immunodeficiency syndrome. When condoms are used properly and in combination with vaginal spermicidal foam, the contrac...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：:Streptomycin is still the treatment of choice for tularemia and plague, and is effective in a few other diseases. Neomycin is used primarily as a topical agent. The other aminoglycoside antibiotics are indicated in serious infections caused by the gram-negative enterobacteria and, except for kanamycin, are also effect...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Although testicular cancer accounts for only 1 percent of all tumors in males, it is the most common malignancy in males between 15 and 34 years of age. Cryptorchidism is the most significant risk factor for testicular cancer, increasing the risk up to 11-fold. A painless testicular mass is the classic presentation fo...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:Celiac disease is a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. The immune inflammatory response to gluten frequently causes damage to many other tissues of the body. The condition is frequently underdiagnosed because of its protean presentations. New prevalence data indicate t...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：:Myocardial perfusion imaging with stress testing by exercise or pharmacologic methods and functional evaluation of the left ventricle are useful in many patients. Uses include determination of diagnosis and prognosis of patients with coronary artery disease, preoperative evaluation, management and risk stratification ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Portal hypertension is a frequent consequence of liver disease, especially alcoholic cirrhosis. Unabated elevations in portal pressure may presage an esophageal variceal hemorrhage. Propranolol or isosorbide therapy is effective in the prophylaxis of variceal bleeding. In patients with acute variceal hemorrhage, endos...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:Use of performance-enhancing supplements occurs at all levels of sports, from professional athletes to junior high school students. Although some supplements do enhance athletic performance, many have no proven benefits and have serious adverse effects. Anabolic steroids and ephedrine have life-threatening adverse eff...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2008-11-01 00:00:00
abstract：:Cigarette smoking causes significant morbidity and mortality in the United States. Physicians can use the five A's framework (ask, advise, assess, assist, arrange) to promote smoking cessation. All patients should be asked about tobacco use and assessed for motivation to quit at every clinical encounter. Physicians sh...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2012-03-15 00:00:00
abstract：:Acute bronchitis is a lower respiratory tract infection that causes reversible bronchial inflammation. In up to 95 percent of cases, the cause, is viral. While antibiotics are often prescribed for patients with acute bronchitis, little evidence shows that these agents provide significant symptomatic relief or shorten ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-15 00:00:00
abstract：:The prognosis remains poor for patients with congestive heart failure (CHF), despite reduced mortality rates resulting from the addition of angiotensin converting enzyme inhibitors to traditional treatment regimens. Because much of the myocardial damage that occurs in patients with CHF may be related to sympathetic ac...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:Atrial fibrillation is associated with potentially life-threatening strokes. Anticoagulation with warfarin or aspirin reduces the risk of embolic events in patients with chronic atrial fibrillation and mitral valve stenosis or other underlying heart disease. In patients with acute onset of atrial fibrillation, anticoa...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1992-06-01 00:00:00
