Motor and phosphene thresholds: a transcranial magnetic stimulation correlation study.

Abstract:

OBJECTIVE:To investigate the stability of visual phosphene thresholds and to assess whether they correlate with motor thresholds. BACKGROUND:Currently, motor threshold is used as an index of cortical sensitivity so that in transcranial magnetic stimulation (TMS) experiments, intensity can be set at a given percentage of this value. It is not known whether this is a reasonable index of cortical sensitivity in non-motor and hence whether it should be used in experiments where other cortical areas are targeted. Previous studies have indicated that phosphene threshold might be a suitable alternative in TMS studies of the visual system. METHOD:Using single pulse TMS visual phosphene and motor thresholds were measured in 15 subjects. Both thresholds were retested in seven of these subjects a week later. RESULT:Visual phosphene thresholds, though stable within subjects across the two sessions, showed greater variability than motor thresholds. There was no correlation between the two measures. CONCLUSION:TMS motor thresholds cannot be assumed to be a guide to visual cortex excitability and by extension are probably an inappropriate guide to the cortical excitability of other non-motor areas of the brain. Phosphene thresholds are proposed as a potential standard for inter-individual comparison in visual TMS experiments.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Stewart LM,Walsh V,Rothwell JC

doi

10.1016/s0028-3932(00)00130-5

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

415-9

issue

4

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(00)00130-5

journal_volume

39

pub_type

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