Abstract:
OBJECTIVE:To investigate the stability of visual phosphene thresholds and to assess whether they correlate with motor thresholds. BACKGROUND:Currently, motor threshold is used as an index of cortical sensitivity so that in transcranial magnetic stimulation (TMS) experiments, intensity can be set at a given percentage of this value. It is not known whether this is a reasonable index of cortical sensitivity in non-motor and hence whether it should be used in experiments where other cortical areas are targeted. Previous studies have indicated that phosphene threshold might be a suitable alternative in TMS studies of the visual system. METHOD:Using single pulse TMS visual phosphene and motor thresholds were measured in 15 subjects. Both thresholds were retested in seven of these subjects a week later. RESULT:Visual phosphene thresholds, though stable within subjects across the two sessions, showed greater variability than motor thresholds. There was no correlation between the two measures. CONCLUSION:TMS motor thresholds cannot be assumed to be a guide to visual cortex excitability and by extension are probably an inappropriate guide to the cortical excitability of other non-motor areas of the brain. Phosphene thresholds are proposed as a potential standard for inter-individual comparison in visual TMS experiments.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Stewart LM,Walsh V,Rothwell JCdoi
10.1016/s0028-3932(00)00130-5subject
Has Abstractpub_date
2001-01-01 00:00:00pages
415-9issue
4eissn
0028-3932issn
1873-3514pii
S0028-3932(00)00130-5journal_volume
39pub_type
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