Functional correlates of preserved naming performance in amnestic Mild Cognitive Impairment.

Abstract:

:Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Catricalà E,Della Rosa PA,Parisi L,Zippo AG,Borsa VM,Iadanza A,Castiglioni I,Falini A,Cappa SF

doi

10.1016/j.neuropsychologia.2015.01.009

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

136-52

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(15)00016-0

journal_volume

76

pub_type

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