Abstract:
:Naming abilities are typically preserved in amnestic Mild Cognitive Impairment (aMCI), a condition associated with increased risk of progression to Alzheimer's disease (AD). We compared the functional correlates of covert picture naming and word reading between a group of aMCI subjects and matched controls. Unimpaired picture naming performance was associated with more extensive activations, in particular involving the parietal lobes, in the aMCI group. In addition, in the condition associated with higher processing demands (blocks of categorically homogeneous items, living items), increased activity was observed in the aMCI group, in particular in the left fusiform gyrus. Graph analysis provided further evidence of increased modularity and reduced integration for the homogenous sets in the aMCI group. The functional modifications associated with preserved performance may reflect, in the case of more demanding tasks, compensatory mechanisms for the subclinical involvement of semantic processing areas by AD pathology.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Catricalà E,Della Rosa PA,Parisi L,Zippo AG,Borsa VM,Iadanza A,Castiglioni I,Falini A,Cappa SFdoi
10.1016/j.neuropsychologia.2015.01.009subject
Has Abstractpub_date
2015-09-01 00:00:00pages
136-52eissn
0028-3932issn
1873-3514pii
S0028-3932(15)00016-0journal_volume
76pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsycholo...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.02.012
更新日期:2019-03-18 00:00:00
abstract::Although imaging studies have indicated that the fusiform gyrus is important in tasks of picture naming, whether this region encodes an object's structure or its meaning is not clear. We used positron emission tomography to examine cerebral blood flow (CBF) changes in response to a picture naming task that varied on t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00083-5
更新日期:2002-01-01 00:00:00
abstract::Verbal fluency test, a type of word generation task, is a commonly used neuropsychological assessment. Among the healthy population, it has been used to assess verbal ability, but also executive functions. In the clinical field, verbal fluency has been used to support the diagnoses of a number of neuropsychological di...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107354
更新日期:2020-02-17 00:00:00
abstract::Previous research has suggested that, when operating in a distributed attention mode, the visual system automatically represents visual displays by their overall statistics, rather than their individual properties. Recent neuropsychological work shows partly preserved distributed attention in simultanagnosic patients,...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.05.014
更新日期:2008-09-01 00:00:00
abstract::Twenty-one patients with unilateral prefrontal cortical neurosurgical lesions (11 left and 10 right) and 38 patients with unilateral temporal lobectomy (19 left and 19 right) were compared to 44 matched control subjects on their performance on the 3-D Computerized Tower of Hanoi (3-D CTOH) test. The problems were spli...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(97)00009-2
更新日期:1997-08-01 00:00:00
abstract::A well-documented feature of Huntington's disease (HD) is disproportionate impairment in the ability to recognise the emotional expression of disgust. However, this finding has been challenged by studies that report no differential disgust impairment and attribute apparent differences across emotions to task difficult...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.04.018
更新日期:2008-09-01 00:00:00
abstract::A new test to detect unilateral neglect was devised using a modified version of the Wundt-Jastrow area illusion. The test was given to three groups of subjects: left brain damaged (LBD), right brain damaged (RBD) patients and controls. Of RBD patients, 40.4% but no LBD patient or control, showed responses inconsistent...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(88)90039-5
更新日期:1988-01-01 00:00:00
abstract::The performance of developmentally dyslexic children and adults was studied upon a range of tasks that involved executive functioning. Both adult and child samples of dyslexics were found to under-perform on the group-embedded figures test. This test required the identification of constituent parts from within complex...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/s0028-3932(02)00046-5
更新日期:2002-01-01 00:00:00
abstract::Recognition of facial expressions of emotion was investigated in people with medicated and unmedicated Parkinson's disease (PD) and matched controls (unmedicated PD, n=16; medicated PD, n=20; controls, n=40). Participants in the medicated group showed some visual impairment (impaired contrast sensitivity) and performe...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(02)00295-6
更新日期:2003-01-01 00:00:00
abstract::Recent evidence suggests that lifelong bilingualism may contribute to cognitive reserve (CR) in normal aging. However, there is currently no neuroimaging evidence to suggest that lifelong bilinguals can retain normal cognitive functioning in the face of age-related neurodegeneration. Here we explored this issue by com...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.09.037
更新日期:2013-11-01 00:00:00
abstract::Amnesia leads to a deficit in recollection that leaves familiarity-based recognition relatively spared. Familiarity is thought to be based on the fluent processing of studied items compared to novel items. However, whether amnesic patients respond normally to direct manipulations of processing fluency is not yet known...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.12.008
更新日期:2014-02-01 00:00:00
abstract::When the primary visual cortex (V1) is damaged, there are a number of alternative pathways that can carry visual information from the eyes to extrastriate visual areas. Damage to the visual cortex from trauma or infarct is often unilateral, extensive and includes gray matter and white matter tracts, which can disrupt ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.10.022
更新日期:2010-12-01 00:00:00
abstract::ADHD status affects both bottom-up sensory processing and top-down attentional selection, impairing professional and social functioning. The objective of the study was to investigate the functional mechanisms of attention deficits in adult ADHD by examining the electrophysiological activities associated with bottom-up...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.05.008
更新日期:2016-07-01 00:00:00
abstract::From birth, the human visual system shows a remarkable sensitivity for perceiving biological motion. This visual ability relies on a distributed network of brain regions and can be preserved even after damage of high-level ventral visual areas. However, it remains unknown whether this critical biological skill can wit...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.11.009
更新日期:2016-12-01 00:00:00
abstract::We localized the neuroanatomical correlates for control of saccadic eye movements and for finger movements using a combined transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) approach. Two participants underwent TMS while performing an endogenous saccade task. The motor hand area was localize...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(98)00097-9
更新日期:1999-02-01 00:00:00
abstract::The main aim of the present study was to clarify whether different types of grasping may affect the transport component of prehension movements. To this purpose two experiments were carried out. In the first experiment the kinematics of arm movements (transport and manipulation components) were studied in eight normal...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90025-4
更新日期:1991-01-01 00:00:00
abstract::Hemispheric differences in a negative brain potential associated with selectively attending the location and type of stimulation were investigated. The earlier portion of this negativity (between 125 and 222 msec after stimulation) was associated with attending the location of the stimulus. It was symmetrical in the c...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(82)90041-0
更新日期:1982-01-01 00:00:00
abstract::Previous research has consistently shown that the left parietal cortex is critical for numerical processing, but the role of the right parietal lobe has been much less clear. This study used the intraoperative cortical electrical stimulation approach to investigate neural dissociation in the right parietal cortex for ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.06.015
更新日期:2011-08-01 00:00:00
abstract::Since Balint's first description, optic ataxia has been considered as a pure visuomotor impairment produced by a lesion of the posterior parietal cortex. Beyond general agreement on the parietal involvement in visually guided behaviour, the exact role of the dorsal posterior parietal cortex in the temporal aspects of ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2003.12.006
更新日期:2004-01-01 00:00:00
abstract::The objective of this review is to obtain a better understanding of the relationship between manual asymmetries and hemispheric specialization by focusing on the development of hand preference and cerebral lateralization of language. We first sought to describe the development of manual asymmetries for different activ...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2015.12.019
更新日期:2016-12-01 00:00:00
abstract::Visuomotor deficits in parietal patients suffering from Optic Ataxia (OA) have been so far studied during natural reaching movements. We aimed at understanding if these disorders are also present when more abstract visuomotor transformations are involved. A patient with unilateral OA was tested during both standard re...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.07.029
更新日期:2014-10-01 00:00:00
abstract::We studied a male with acquired prosopagnosia using a battery of Implicit Association Tests (IATs) to investigate whether observing faces varying by social category would activate the patient's implicit social biases. We also asked him to categorize faces explicitly by race, gender, and political party. The patient, G...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.03.009
更新日期:2011-06-01 00:00:00
abstract::It has been proposed that the underlying deficit for some simultanagnosics is the inability to bilaterally orient attention in space due to parietal damage. In five experiments, we examine the performance of a patient with simultanagnosia secondary to bilateral occipito-parietal lesions, IC, in naming pairs of line-dr...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00139-7
更新日期:2002-01-01 00:00:00
abstract::Working memory, the ability to maintain and manipulate information over seconds, is central to cognition and it is impaired in many clinical populations. However, our knowledge of the structural properties associated with individual variation in visuospatial working memory capacity is currently poor. Across two locati...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107486
更新日期:2020-06-01 00:00:00
abstract::In a gap paradigm, healthy adult subjects performed visually triggered saccades to peripheral targets either with the fixation stimulus remaining on (overlap trials) or going off before target onset (gap trials). All subjects showed faster reaction times in the gap trials (the gap effect). High density scalp event-rel...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(97)00016-x
更新日期:1997-06-01 00:00:00
abstract::Previous reports have demonstrated that many aspects of number knowledge remain unimpaired in semantic dementia, despite severe comprehension problems in other domains. It is argued that this advantage for numbers arises because the disease spares the parietal lobe magnitude system thought to be critical for number pr...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2004.09.009
更新日期:2005-01-01 00:00:00
abstract::Although many individuals with traumatic brain injury (TBI) perform well on standard neuropsychological tests, they often exhibit marked functional difficulties. The functions which are impaired seem to be analogous to the role of the central executive system (CES) in Baddeley's [Working Memory, 1986, Oxford Universit...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(97)00082-1
更新日期:1997-10-01 00:00:00
abstract::Patients with Parkinson's disease (PD), a degenerative disorder primarily affecting the nigrostriatal dopamine system, exhibit deficits in selecting task-relevant stimuli in the presence of irrelevant stimuli, such as in visual search tasks. However, results from previous studies suggest that these deficits may vary a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.01.037
更新日期:2006-01-01 00:00:00
abstract::Bilateral damage in the posterior cingulate region can induce anterograde amnesia. Identifying the potential contributions of the various areas within this heterogeneous region has, however, largely depended on animal research. Within the posterior cingulate region the retrosplenial cortex stands out by virtue of its ...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2009.09.030
更新日期:2010-07-01 00:00:00
abstract::Neuroimaging studies show that permanent peripheral lesions such as unilateral deafness cause functional reorganization in the auditory pathways. However, functional reorganization of the auditory pathways as a result of higher-level damage or abnormalities remains poorly investigated. A relatively recent behavioural ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.10.023
更新日期:2010-01-01 00:00:00