Secondary immunodeficiencies and stem cell transplantation: issues of administration and safety of intravenous immunoglobulin.

abstract：OBJECTIVE:The aim of this research letter was to describe the use of N-carbamoyl-L-glutamate as first-line treatment of hyperammonemia in a 4-month-old female patient with propionic acidemia (PA). METHODS:A 4-month-old female patient weighing 3.9 kg presented with decompensation with PA and initial hyperammonemia of 4...

journal_title：Clinical therapeutics

authors： Soyucen E,Demirci E,Aydin A

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Plasma concentrations of cloxacillin have been found to vary as much as 20-fold among individuals receiving the same oral dose. There is evidence that cloxacillin may be a substrate for P-glycoprotein, suggesting that polymorphisms in the ABCB1 gene may be a contributing factor to the observed variability in...

journal_title：Clinical therapeutics

authors： Yin OQ,Tomlinson B,Chow MS

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:In diabetes mellitus, the clinical goal of intensive glycemic control (lowering blood glucose concentrations to normal or near-normal levels) has been hindered by the lack of insulin regimens that duplicate the basal-bolus secretion of insulin by the healthy pancreas. In particular, intensive therapy has bee...

journal_title：Clinical therapeutics

authors： Campbell RK,White JR,Levien T,Baker D

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Alendronate, an oral bisphosphonate, is available for the treatment of osteoporosis in a 70-mg once-weekly and a 10-mg once-daily formulation. OBJECTIVES:This study aimed to determine patient preference for once-weekly versus once-daily dosing with alendronate, and to determine which treatment regimen the p...

journal_title：Clinical therapeutics

authors： Simon JA,Lewiecki EM,Smith ME,Petruschke RA,Wang L,Palmisano JJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Insulin therapy may eventually be required to maintain glycemic control in many patients with type 2 diabetes mellitus. Premixed insulin analogues offer relatively physiologic and predictable time-action profiles and are available in more convenient delivery systems with finer needles than in the past. They ...

journal_title：Clinical therapeutics

authors： Rolla AR,Rakel RE

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The purposes of this review are to describe the pathogenesis of mucormycosis and to address recent research advances in understanding the mechanisms of fungal invasion and dissemination. METHODS:Studies and reviews published in the PubMed and ClinicalTrials.gov databases until December 2017 that explored or re...

journal_title：Clinical therapeutics

authors： Petrikkos G,Tsioutis C

更新日期：2018-06-01 00:00:00

abstract：:A benzothiazepine derivative, CRD-401, was administered orally in a dosage of 60 to 120 mg/day to 14 patients with various renal diseases. The systolic pressure was lowered slightly in some cases after administration of CRD-401. Urine volume and urinary excretion of electrolytes were increased by the drug in most pati...

journal_title：Clinical therapeutics

authors： Funyu T,Nigawara K,Ohno K,Hamada W,Yagihashi Y

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:We conducted a retrospective cohort study to compare medication use patterns of a long-acting extended-release methylphenidate (Osmotic Release Oral System [OROS(®)] methylphenidate, CONCERTA(®)) and Teva-methylphenidate (methylphenidate ER-C), a generic drug determined by the Canadian regulatory authority, Hea...

journal_title：Clinical therapeutics

authors： Park-Wyllie L,Van Stralen J,Almagor D,Dobson-Belaire W,Charland K,Smith A,Le Lorier J

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Patients newly diagnosed with type 2 diabetes mellitus generally initiate therapy with either metformin [Met] or a sulfonylurea [SU] drug, followed by the addition of a second agent (Met, an SU drug, or a thiazolidinedione [TZD] drug) if the diabetes is not well controlled. If necessary, the usual third line...

journal_title：Clinical therapeutics

authors： Rascati KL,Richards KM,Lopez D,Cheng LI,Wilson JP

更新日期：2011-12-01 00:00:00

abstract：:Fourteen patients with serious infections caused by Staphylococcus aureus and other gram-positive bacteria were prospectively treated with chromatographically purified vancomycin in an open-label, nonrandomized study, between December 1986 and June 1987. Five patients were excluded from the evaluation of efficacy. Amo...

journal_title：Clinical therapeutics

authors： Wang LS,Liu CY,Wang FD,Fung CP,Chiu ZH,Cheng DL

更新日期：1988-01-01 00:00:00

abstract：:This study was designed to determine changes in the number of beta-adrenergic receptors of circulating lymphocytes in patients with varying degrees of congestive heart failure. Thirty-seven patients with congestive heart failure were classified into four groups according to the functional classifications of the New Yo...

journal_title：Clinical therapeutics

authors： Okada N,Ito T,Satake T

更新日期：1989-05-01 00:00:00

abstract：:In two multicenter, double-blind studies, ciclopirox olamine cream 1% was compared with either its cream vehicle or with 1% clotrimazole cream for the treatment of patients with tinea pedis. Evaluations were made before treatment, weekly for four weeks during treatment, and for two weeks posttreatment. Ciclopirox olam...

journal_title：Clinical therapeutics

authors：

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Postherpetic neuralgia (PHN), which affects up to 70% of elderly persons with herpes zoster, can have debilitating effects, including physical and social disability and significant psychological distress. A variety of agents have been used, either singly or in combination, to control PHN, including topical a...

journal_title：Clinical therapeutics

authors： Stacey BR,Glanzman RL

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Stroke is the second leading cause of death and the third leading cause of disability worldwide. Diabetes mellitus and the associated hyperglycemia are important risk factors for acute ischemic stroke and are associated with poor prognosis. Neurovascular protection is an important therapeutic target to achieve ...

journal_title：Clinical therapeutics

authors： Al Hamed FA,Elewa H

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:In a previous study, we found that past medication use was associated with medication adherence in patients prescribed atypical antipsychotics. OBJECTIVE:The present study aimed to determine whether past medication experience was associated with adherence in patients prescribed selective serotonin reuptake ...

journal_title：Clinical therapeutics

authors： Vanelli M,Coca-Perraillon M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Idiopathic thrombocytopenic purpura (ITP) is a relatively rare acquired autoimmune disease characterized by either decreased platelet production or increased platelet destruction leading to reduced platelet counts and increased risk of bleeding. Immune modulators have been used in treatment; however, a novel...

journal_title：Clinical therapeutics

authors： Zhang Y,Kolesar JM

更新日期：2011-11-01 00:00:00

abstract：:Healing rates were examined retrospectively in 124 outpatients with peptic ulcer who had received cimetidine for at least four weeks. Treatment was unsuccessful in 73 patients. A statistical analysis of the factors involved in treatment failure revealed that in patients with duodenal ulcers 60.6% of the treatment succ...

journal_title：Clinical therapeutics

authors： Granelli P,Angelini GP,Celli L

更新日期：1984-01-01 00:00:00

abstract：:Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl...

journal_title：Clinical therapeutics

authors： Sperber K,Chiang G,Chen H,Ross W,Chusid E,Gonchar M,Chow R,Liriano O

更新日期：1997-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder, with a rapidly increasing worldwide prevalence. Although no cure for AD has yet been found, substantial progress has been made in our understanding of AD pathogenesis. This progress has led to the development of numerous promising compounds in vario...

journal_title：Clinical therapeutics

authors： Nygaard HB

更新日期：2013-10-01 00:00:00

abstract：:In this open-label, randomized, cross-over study, 12 healthy subjects received four doses of a new sustained-release formulation of diltiazem hydrochloride for six consecutive days. Blood samples were drawn on days 5 and 6 for determination of plasma diltiazem and desacetyldiltiazem levels. The peak concentrations aft...

journal_title：Clinical therapeutics

authors： Ziemniak J,Colligon I,Heald D

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To evaluate the safety and efficacy of glycoprotein IIb/IIIa inhibitors (GPIs) in patients with acute myocardial infarction (AMI) in the presence of intracoronary thrombus undergoing percutaneous coronary interventions. METHODS:This study, performed from January 1, 2004, to November 31, 2014, at 55 centers in ...

journal_title：Clinical therapeutics

authors： Zheng C,Kang J,Yang HM,Han JK,Park KW,Kang HJ,Koo BK,Kim HS

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In vitro studies have demonstrated that ticagrelor, an oral antiplatelet agent, is a substrate, activator, and inhibitor of cytochrome P450 (CYP) 3A. Thus, potential CYP3A-mediated drug-drug interactions may occur. OBJECTIVES:The goal of this article was to report study results on the effect of ticagrelor o...

journal_title：Clinical therapeutics

authors： Teng R,Butler K

更新日期：2013-07-01 00:00:00

abstract：:A comparison of single-agent antimicrobial therapy in the treatment of patients with perforated or gangrenous appendicitis and peritonitis was performed in a double-blind, randomized, prospective trial. Pathologic documentation of advanced appendicitis and positive intraoperative specimen cultures were required for in...

journal_title：Clinical therapeutics

authors： Bennion RS,Thompson JE,Baron EJ,Finegold SM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is a fatal motor neuron disease of childhood that is caused by mutations in the SMN1 gene. Currently, no effective treatment is available. One possible therapeutic approach is the use of antisense oligos (ASOs) to redirect the splicing of the paralogous gene SMN2, thus increasin...

journal_title：Clinical therapeutics

authors： Nizzardo M,Simone C,Salani S,Ruepp MD,Rizzo F,Ruggieri M,Zanetta C,Brajkovic S,Moulton HM,Müehlemann O,Bresolin N,Comi GP,Corti S

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Patients with mild intermittent or mild persistent asthma represent 70% of asthma sufferers. Inhaled corticosteroids (ICSs) are the mainstay of treatment for persistent asthma, although many of the early clinical studies of these drugs included only patients with moderate to severe asthma. OBJECTIVE:This ar...

journal_title：Clinical therapeutics

authors： Eigen H

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Depot medroxyprogesterone acetate (DMPA) is an effective (<1% annual failure rate) contraceptive administered by intramuscular injection every 3 months. DMPA is an increasingly popular contraceptive choice for adolescents, yet its use is associated with weight gain as well as subsequent nonadherence and long...

journal_title：Clinical therapeutics

authors： Gerlach LS,Saldaña SN,Wang Y,Nick TG,Spigarelli MG

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:We assessed the effects of coadministration of metformin and teneligliptin on their pharmacokinetics in steady-state conditions relative to the administration of either drug alone. METHODS:This was a Phase I, single-center, open-label, 2-way parallel-group study in healthy male and female subjects. Subjects in...

journal_title：Clinical therapeutics

authors： Nakamaru Y,Hayashi Y,Davies M,Jürgen Heuer H,Hisanaga N,Akimoto K

更新日期：2015-09-01 00:00:00

abstract：:Twenty-seven Escherichia coli test strains that were not susceptible to cephalothin were tested for susceptibility to cefazolin, cefamandole, and ceforanide. By zone-size criteria (greater than or equal to 18 mm), 67% of E coli were susceptible to cefazolin and cefamandole, and 93% were susceptible to ceforanide. By m...

journal_title：Clinical therapeutics

authors： Greenberg RN,Bollinger M

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The utilization pattern of dronedarone was unknown, especially regarding prescribers' compliance with the product's prescribing information (PI) following its availability and the implementation of the Food and Drug Administration-approved risk evaluation and mitigation strategy for the drug in the United St...

journal_title：Clinical therapeutics

authors： Gao S,Juhaeri J,Schiappacasse HA,Koren AT,Dai WS

更新日期：2011-10-01 00:00:00

abstract：:Self-care with over-the-counter (OTC) medicines has evolved from the "dark ages" of patent medicine manufacture and sale to a modern era of new drug development involving prescription-to-OTC switch. This evolution is largely due to the OTC Review, which placed science at the cornerstone of safety, effectiveness, and l...

journal_title：Clinical therapeutics

authors： Soller RW

更新日期：1998-01-01 00:00:00