当前位置： SCI文献检索 > CLINICAL THERAPEUTICS期刊下所有文献 > Medication Persistence, Duration of Treatment, and Treatment-switching Patterns Among Canadian Patients Taking Once-daily Extended-release Methylphenidate Medications for Attention-Deficit/Hyperactivity Disorder: A Population-based Retrospective Cohort St

Medication Persistence, Duration of Treatment, and Treatment-switching Patterns Among Canadian Patients Taking Once-daily Extended-release Methylphenidate Medications for Attention-Deficit/Hyperactivity Disorder: A Population-based Retrospective Cohort St

Abstract：

PURPOSE:We conducted a retrospective cohort study to compare medication use patterns of a long-acting extended-release methylphenidate (Osmotic Release Oral System [OROS(®)] methylphenidate, CONCERTA(®)) and Teva-methylphenidate (methylphenidate ER-C), a generic drug determined by the Canadian regulatory authority, Health Canada, to be bioequivalent to OROS(®) methylphenidate. METHODS:We established an OROS(®) methylphenidate-experienced and new-user population cohort to compare medication use patterns, including medication persistence, duration of therapy, and treatment-switching patterns. Multivariable log-binomial regression was used to adjust for confounders of the associations with persistence. FINDINGS:In the OROS(®) methylphenidate-experienced cohort (n = 21,940), OROS(®) methylphenidate was associated with a 70% higher rate of medication persistence at 12 months relative to methylphenidate ER-C (adjusted relative risk = 1.70; 95% CI, 1.64-1.77). In the new-user cohort (n = 20,410), OROS(®) methylphenidate had a 58% higher rate of medication persistence relative to methylphenidate ER-C (adjusted relative risk = 1.58; 95% CI, 1.51-1.65). Median duration of therapy was significantly longer in patients taking OROS(®) methylphenidate compared with those taking methylphenidate ER-C, and treatment-switching occurred significantly more frequently in patients taking methylphenidate ER-C compared with those taking OROS(®) methylphenidate. IMPLICATIONS:Significant differences were observed in how the medications were used by patients in the real-world setting. Because the data sources were administrative databases, it was not possible to control for all potentially important confounding variables. Although differences in medication persistence may not directly reflect differences in treatment efficacy, the findings are important because these products are used interchangeably in a number of Canadian provinces.

journal_name

Clin Ther

journal_title

Clinical therapeutics

authors

Park-Wyllie L,Van Stralen J,Almagor D,Dobson-Belaire W,Charland K,Smith A,Le Lorier J

doi

10.1016/j.clinthera.2016.07.001

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1789-802

issue

8

eissn

0149-2918

issn

1879-114X

pii

S0149-2918(16)30443-X

journal_volume

38

pub_type

杂志文章

相关文献

CLINICAL THERAPEUTICS文献大全
  • In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens.

    abstract：:Macrolide and beta-lactam antimicrobial agents are frequently used for the treatment of upper and lower respiratory tract infections and skin or skin structure infections. To evaluate the relative in vitro activity of these antimicrobial drugs against organisms commonly involved in these infections, we tested clarithr...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Ritchie DJ,Hopefl AW,Milligan TW,Byrne JE,Maddux MS

    更新日期：1993-01-01 00:00:00

  • Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers.

    abstract：BACKGROUND:Varenicline, a selective alpha4beta2 nicotinic acetylcholine receptor partial agonist, has been developed specifically for smoking cessation. In Japan, 39.3% of men smoke and this is a major public health concern. OBJECTIVE:The primary objective of this study was to evaluate the efficacy and dose-response r...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.clinthera.2007.06.012

    authors： Nakamura M,Oshima A,Fujimoto Y,Maruyama N,Ishibashi T,Reeves KR

    更新日期：2007-06-01 00:00:00

  • Etodolac, aspirin, and placebo in patients with rheumatoid arthritis: a 12-week study.

    abstract：:Etodolac, aspirin, and placebo were evaluated for efficacy and safety in 18 patients with adult-onset, active rheumatoid arthritis. This was a 12-week, double-blind, parallel-group study divided into drug titration and maintenance periods and preceded by a washout period of up to two weeks. The mean daily maintenance ...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章

    doi：

    authors： Edwards W

    更新日期：1983-01-01 00:00:00

  • Long-term oral antiarrhythmic therapy with aprindine: effects on cardiac function and adverse effects.

    abstract：:The effects of long-term aprindine administration on cardiac function were clinically investigated in seven patients with supraventricular or ventricular arrhythmias associated with organic heart disease. Three patients had normal cardiac function and four had various degrees of cardiac dysfunction before treatment wi...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Tsutsui H,Araki H,Nagata Y,Nakamura M

    更新日期：1984-01-01 00:00:00

  • FlexPen: addressing issues of confidence and convenience in insulin delivery.

    abstract：BACKGROUND:In people with type 1 or type 2 diabetes, poor adherence to insulin therapy can compromise disease management. There are several reasons for poor adherence, including social embarrassment, inconvenience, needle anxiety, fear of injection pain, and complicated regimens. Attempts to facilitate implementation o...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2005.11.019

    authors： Korytkowski M,Niskanen L,Asakura T

    更新日期：2005-01-01 00:00:00

  • Sparfloxacin: a review.

    abstract：BACKGROUND:The continuing increase in the rate of penicillin and cephalosporin resistance among respiratory pathogens and of cross-resistance to macrolide antibiotics has led to the recommendation that fluoroquinolone antibiotics be used to treat high-risk patients with community-acquired pneumonia (CAP) and acute bact...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/S0149-2918(00)89007-4

    authors： Schentag JJ

    更新日期：2000-04-01 00:00:00

  • Effects of felodipine on natriuresis, atrial natriuretic factor, the renin-angiotensin-aldosterone system, and blood pressure in essential hypertension.

    abstract：:The aim of this study was to evaluate the short-term and long-term effects of felodipine, a new dihydropiridine calcium antagonist, on arterial blood pressure (BP), the renin-angiotensin-aldosterone system, diuresis, natriuresis, and the atrial natriuretic factor (ANF). In 15 essential hypertensives (WHO class II) BP,...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Cerasola G,Cottone S,Mangano MT,D'Ignoto G,Pinto A,Carone MB

    更新日期：1988-01-01 00:00:00

  • Relative Bioavailability of Methylphenidate Extended-release Chewable Tablets Chewed Versus Swallowed Whole.

    abstract：PURPOSE:Methylphenidate hydrochloride extended-release chewable tablet (MPH ERCT) is approved for treatment of attention deficit hyperactivity disorder in patients aged 6 years and older. This article evaluates the pharmacokinetic parameters and relative bioavailability of MPH ERCT when chewed versus swallowed whole. ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2018.03.016

    authors： Abbas R,Childress AC,Nagraj P,Rolke R,Berry SA,Palumbo DR

    更新日期：2018-05-01 00:00:00

  • Changes in the number of beta-adrenergic receptors of lymphocytes in patients with varying degrees of congestive heart failure.

    abstract：:This study was designed to determine changes in the number of beta-adrenergic receptors of circulating lymphocytes in patients with varying degrees of congestive heart failure. Thirty-seven patients with congestive heart failure were classified into four groups according to the functional classifications of the New Yo...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Okada N,Ito T,Satake T

    更新日期：1989-05-01 00:00:00

  • Pharmacokinetic bridging approach for developing biologics-delivery devices: a case study with a golimumab autoinjector.

    abstract：PURPOSE:This Phase 1 pharmacokinetic (PK) comparability study in healthy subjects was performed to compare the PK properties and tolerability of single-dose golimumab 100 mg delivered subcutaneously by an autoinjector device or by a standard needle and syringe that had been used for the subcutaneous (SC) delivery of go...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2014.09.012

    authors： Xu Z,Marciniak SJ Jr,Frederick B,Kim L,Zhuang Y,Davis HM,Zhou H

    更新日期：2015-02-01 00:00:00

  • The effects of enalapril on blood pressure, renal hemodynamics, and renal function.

    abstract：:Since the introduction of angiotensin converting enzyme (ACE) inhibitors into clinical use, much information has been accumulated in animal models and man regarding their effects on renal function in different disease states. Enalapril, the first nonsulfhydryl ACE inhibitor approved for general use in the United State...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：

    authors： Weir MR

    更新日期：1989-09-01 00:00:00

  • Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes.

    abstract：PURPOSE:The effects of air pollutants have been receiving increased attention both clinically and in the media. One such pollutant is mold, fungal growth in the form of multicellular filaments known as hyphae. The growth of molds is omnipresent not only in outdoor settings but also in indoor environments containing exc...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2018.05.004

    authors： Ratnaseelan AM,Tsilioni I,Theoharides TC

    更新日期：2018-06-01 00:00:00

  • Cost-effectiveness of everolimus for second-line treatment of metastatic renal cell carcinoma in Serbia.

    abstract：BACKGROUND:New targeted therapeutics for metastatic renal cell carcinoma (mRCC) enable an increment in progression-free survival (PFS) ranging from 2 to 6 months. Compared with best supportive care, everolimus demonstrated an additional PFS of 3 months in patients with mRCC whose disease had progressed on sunitinib and...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2013.10.004

    authors： Mihajlović J,Pechlivanoglou P,Sabo A,Tomić Z,Postma MJ

    更新日期：2013-12-01 00:00:00

  • Management of acute coronary syndromes in patients with diabetes: implications of the FREEDOM trial.

    abstract：BACKGROUND:Diabetes mellitus (DM) is a powerful independent risk factor for multivessel, diffuse coronary artery disease (CAD). The optimal coronary revascularization strategy in DM is not clearly defined, but past trials have suggested an advantage for coronary artery bypass grafting (CABG). Recently, the Future Revas...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2013.07.427

    authors： Burgess SN,Mussap CJ,French JK

    更新日期：2013-08-01 00:00:00

  • Glycemic Control Outcomes After Canagliflozin Initiation: Observations in a Medicare and Commercial Managed Care Population in Clinical Practice.

    abstract：PURPOSE:Although the efficacy of canagliflozin has been well established in clinical trials, research regarding its use and impact on outcomes in clinical practice has been limited by the availability of data on observations up to and beyond 6 months after the initial use of canagliflozin. The purpose of this study was...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2016.07.009

    authors： Bailey RA,Schwab P,Xu Y,Pasquale M,Renda A

    更新日期：2016-09-01 00:00:00

  • New insights and treatments: opiate withdrawal and cocaine addiction.

    abstract：:Basic research in the neurosciences has led to a theory of opiate withdrawal involving endogenous opioid peptides and hyperactive norepinephrine neurons. This theory predicts the efficacy of clonidine, a nonopiate agent, in the management of opiate withdrawal. Clonidine, which offers numerous advantages over methadone...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：

    authors： Gold MS,Dackis CA

    更新日期：1984-01-01 00:00:00

  • Inhaled dry powder insulin for the treatment of diabetes mellitus.

    abstract：BACKGROUND:Inhaled dry powder insulin (IDPI) is the first inhaled insulin approved for the treatment of type 1 and type 2 diabetes mellitus (DM). OBJECTIVE:This article reviews available information on IDPI, focusing on its clinical pharmacokinetics, comparative efficacy, tolerability, adverse events, dosage and admin...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2007.05.015

    authors： Setter SM,Levien TL,Iltz JL,Odegard PS,Neumiller JJ,Baker DE,Campbell RK

    更新日期：2007-05-01 00:00:00

  • Evolution of Business Models in Regenerative Medicine: Effects of a Disruptive Innovation on the Innovation Ecosystem.

    abstract：PURPOSE:This article focuses on 10 case studies of companies/organizations that are part of the current innovation ecosystem of regenerative medicine (RM) in the United Kingdom. It analyzes the actors, linkages, and influences that will determine the future shape of the RM industry sector and its capacity to live up to...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2018.06.003

    authors： Banda G,Tait J,Mittra J

    更新日期：2018-07-01 00:00:00

  • Correspondence between the RAND-Negative Impact of Asthma on Quality of Life item bank and the Marks Asthma Quality of Life Questionnaire.

    abstract：BACKGROUND:In many research and clinical settings in which patient-reported outcome (PRO) measures are used, it is often desirable to link scores across disparate measures or to use scores from 1 measure to describe scores on a separate measure. However, PRO measures are scored by using a variety of metrics, making suc...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2014.04.007

    authors： Edelen MO,Stucky BD,Sherbourne C,Eberhart N,Lara M

    更新日期：2014-05-01 00:00:00

  • Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet.

    abstract：OBJECTIVE:The aim of this study was to assess obese patients with hypercholesterolemia whom were prescribed a standardized diet, comparing the action of orlistat, fluvastatin, orlistat with fluvastatin, and placebo on anthropometric measurements, blood pressure (BP), and lipid profile. METHODS:This was a 1-year, rando...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0149-2918(03)80070-x

    authors： Derosa G,Mugellini A,Ciccarelli L,Fogari R

    更新日期：2003-04-01 00:00:00

  • Effects of Exercise on Non-motor Symptoms in Parkinson's Disease.

    abstract：:Patients with Parkinson's disease experience disabling non-motor symptoms, including autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for these symptoms are often ineffective or have intolerable side effects. Therefore, non-pharmacologic interventions are an attractive alternativ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2017.11.004

    authors： Amara AW,Memon AA

    更新日期：2018-01-01 00:00:00

  • Rotavirus live, oral, pentavalent vaccine.

    abstract：BACKGROUND:On February 3, 2006, the US Food and Drug Administration (FDA) approved a live, oral, pentavalent (G1-G4, P1[8]) human-bovine reassortant rotavirus vaccine for the prevention of rotavirus gastroenteritis (RVGE) in infants in the United States. The Advisory Committee of Immunization Practices of the Centers f...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2007.12.018

    authors： Tom-Revzon C

    更新日期：2007-12-01 00:00:00

  • Pegylated interferons for the treatment of chronic hepatitis C infection.

    abstract：BACKGROUND:Interferon (IFN) alfa is a clinically effective therapy used in a wide range of viral infections and cell-proliferative disorders. Combination therapy with IFN alfa-2b and ribavirin is the current standard of care for the treatment of chronic hepatitis C (CHC) infection. However, standard IFN alfa has the dr...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-2918(02)80042-x

    authors： Luxon BA,Grace M,Brassard D,Bordens R

    更新日期：2002-09-01 00:00:00

  • Topical corticosteroid therapy for children: alclometasone dipropionate cream 0.05%.

    abstract：:The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. For the remaining 33 children, levels we...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Crespi HG

    更新日期：1986-01-01 00:00:00

  • Ofloxacin in the treatment of typhoid fever resistant to chloramphenicol and amoxicillin.

    abstract：:Twenty-five patients with typhoid fever, who were resistant to amoxicillin and chloramphenicol, were successfully treated with ofloxacin. Ofloxacin was administered at a dosage of 200 mg three times daily for 7 to 10 days. In a few seriously ill patients, a dosage of 400 mg three times daily for 3 days, followed by 20...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章

    doi：

    authors： Khan MA,Hayat Z,Sadick A

    更新日期：1994-09-01 00:00:00

  • A prospective, randomized, double-blind, placebo-controlled study to assess the antiemetic effects of midazolam on postoperative nausea and vomiting in women undergoing laparoscopic gynecologic surgery.

    abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) are distressing and frequent adverse effects (AEs) in women undergoing laparoscopic gynecologic surgery. Midazolam has been reported to be effective for preventing PONV in adults undergoing middle ear surgery and children undergoing strabismus surgery or tonsillectomy...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验,收录出版

    doi：10.1016/j.clinthera.2010.08.005

    authors： Fujii Y,Itakura M

    更新日期：2010-08-01 00:00:00

  • Restless Legs Symptoms and Pregnancy and Neonatal Outcomes.

    abstract：PURPOSE:Restless legs syndrome (RLS) is a commonly occurring neurologic disorder that affects up to one third of women during pregnancy. RLS has been associated with increased sympathetic tone in the nonpregnant population. We examined whether a RLS surrogate is associated with a higher prevalence of pregnancy and neon...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2015.11.021

    authors： Oyieng'o DO,Kirwa K,Tong I,Martin S,Antonio Rojas-Suarez J,Bourjeily G

    更新日期：2016-02-01 00:00:00

  • Importance of observational studies in clinical practice.

    abstract：BACKGROUND:In this era of evidence-based medicine, clinicians require a comprehensive range of well-designed studies to support prescribing decisions and patient management. In recent years, data from observational studies have become an increasingly important source of evidence because of improvements in observational...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2007.07.004

    authors： Ligthelm RJ,Borzì V,Gumprecht J,Kawamori R,Wenying Y,Valensi P

    更新日期：2007-06-01 00:00:00

  • Echinacea in the prevention of induced rhinovirus colds: a meta-analysis.

    abstract：BACKGROUND:The therapeutic effectiveness of Echinacea in the treatment and the prevention of colds has been debated. Studies of naturally occurring colds are hampered by variability in time from onset of symptoms to treatment and by heterogeneity in trial design. Experimental infection studies allow for the standardiza...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.clinthera.2006.02.001

    authors： Schoop R,Klein P,Suter A,Johnston SL

    更新日期：2006-02-01 00:00:00

  • Randomized, multinational, open-label, 2-period, crossover comparison of biphasic insulin aspart 30 and biphasic insulin lispro 25 and pen devices in adult patients with type 2 diabetes mellitus.

    abstract：OBJECTIVE:The goal of this study was to compare the efficacy and safety profiles of biphasic insulin aspart 30 (30% soluble insulin aspart and 70% protaminated insulin aspart [BIAsp 30]) and biphasic insulin lispro 25 (25% soluble insulin lispro and 75% neutral protamine lispro [Mix25]) used in a BID injection regimen ...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0149-2918(04)90055-0

    authors： Niskanen L,Jensen LE,Råstam J,Nygaard-Pedersen L,Erichsen K,Vora JP

    更新日期：2004-04-01 00:00:00