当前位置： SCI文献检索 > CLINICAL THERAPEUTICS期刊下所有文献 > Pegylated interferons for the treatment of chronic hepatitis C infection.

Pegylated interferons for the treatment of chronic hepatitis C infection.

Abstract：

BACKGROUND:Interferon (IFN) alfa is a clinically effective therapy used in a wide range of viral infections and cell-proliferative disorders. Combination therapy with IFN alfa-2b and ribavirin is the current standard of care for the treatment of chronic hepatitis C (CHC) infection. However, standard IFN alfa has the drawbacks of a short serum half-life and rapid clearance. To overcome this problem, 2 pegylated forms of IFN have been developed and tested clinically. OBJECTIVE:This article reviews the development and properties of pegylated IFN alfa-2b and pegylated IFN alfa-2a, and presents safety and efficacy data from recent clinical trials. METHODS:Relevant clinical studies were identified through a MEDLINE search from 1966 through the present using the key words hepatitis C and interferon. Studies of the pegylated IFNs in humans were then selected. RESULTS:Pegylated IFN alfa-2b is formed by covalent conjugation of a 12-kd mono-methoxy polyethylene glycol (PEG) molecule to IFN alfa-2b, and pegylated IFN alfa-2a by covalent conjugation of a 40-kd branched mono-methoxy PEG molecule to IFN alfa-2a. The 2 pegylated IFNs differ in the mixture of pegylation isomers resulting from their conjugation chemistry. Pegylated IFN alfa-2b has a prolonged serum half-life (40 hours) relative to standard IFN alfa-2b (7-9 hours). The greater polymer size of pegylated IFN alfa-2a acts to reduce glomerular filtration, markedly prolonging its serum half-life (72-96 hours) compared with standard IFN alfa-2a (6-9 hours). In clinical studies, once-weekly dosing of the pegylated IFNs was associated with a sustained virologic response in patients infected with hepatitis C virus (HCV). Once-weekly dosing with either of the pegylated IFNs was more effective than the respective thrice-weekly regimen of IFN alfa, with a comparable safety profile. The combination of once-weekly pegylated IFN and ribavirin effectively reduced HCV viral load and sustained viral suppression. CONCLUSIONS:Once-weekly dosing with either pegylated IFN alfa-2b or pegylated IFN alfa-2a has been shown to produce significantly higher rates of viral eradication than standard thrice-weekly IFN alfa therapy without compromising safety. With respect to the treatment of CHC, the greatest anti-HCV efficacy has been achieved with the combination of once-weekly pegylated IFN and ribavirin.

journal_name

Clin Ther

journal_title

Clinical therapeutics

authors

Luxon BA,Grace M,Brassard D,Bordens R

doi

10.1016/s0149-2918(02)80042-x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1363-83

issue

9

eissn

0149-2918

issn

1879-114X

pii

S0149-2918(02)80042-X

journal_volume

24

pub_type

杂志文章,评审

相关文献

CLINICAL THERAPEUTICS文献大全
  • Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older.

    abstract：PURPOSE:Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common functional gastrointestinal disorders. The prevalence of constipation-related issues tends to increase with age. This analysis pooled data from Phase III trials in CIC and IBS-C to assess the safety and effic...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2020.05.012

    authors： Menees SB,Franklin H,Chey WD

    更新日期：2020-07-01 00:00:00

  • Comparison of the clinical effects of carbomer-based lipid-containing gel and hydroxypropyl-guar gel artificial tear formulations in patients with dry eye syndrome: a 4-week, prospective, open-label, randomized, parallel-group, noninferiority study.

    abstract：BACKGROUND:Most marketed artificial tears are substitutes for the aqueous layers of the tear film; therefore, frequent instillation of artificial tears is necessary. Newer gel-, cellulose-, and mineral oil-based formulations have been designed to overcome the disadvantages of current aqueous tear substitutes by offerin...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2010.01.024

    authors： Wang TJ,Wang IJ,Ho JD,Chou HC,Lin SY,Huang MC

    更新日期：2010-01-01 00:00:00

  • Tolerability and blood pressure-lowering efficacy of the combination of amlodipine plus valsartan compared with lisinopril plus hydrochlorothiazide in adult patients with stage 2 hypertension.

    abstract：BACKGROUND:Most patients with hypertension in the United States and Europe fail to achieve the recommended target blood pressure (BP) of <140/90 mm Hg. Combination therapy is required in approximately two thirds of all patients whose BP is >20/10 mm Hg above the goal. Combination therapy with agents having complementar...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.clinthera.2007.02.003

    authors： Poldermans D,Glazes R,Kargiannis S,Wernsing M,Kaczor J,Chiang YT,Yen J,Gamboa R,Fomina I

    更新日期：2007-02-01 00:00:00

  • Antimicrobial-resistant Pseudomonas aeruginosa and Acinetobacter baumannii From Patients With Hospital-acquired or Ventilator-associated Pneumonia in Vietnam.

    abstract：PURPOSE:Multidrug-resistant bacterial pathogens are becoming a significant problem worldwide. Acinetobacter baumannii and Pseudomonas aeruginosa are problematic multidrug-resistant pathogens. This multicenter study in Vietnam determined the level of resistance to antimicrobial agents used to treat A baumannii and P aer...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.clinthera.2016.07.172

    authors： Biedenbach DJ,Giao PT,Hung Van P,Su Minh Tuyet N,Thi Thanh Nga T,Phuong DM,Vu Trung N,Badal RE

    更新日期：2016-09-01 00:00:00

  • Vitamin D Provides Benefit Based on the Proinflammatory Effects of Homocysteine in Elderly Patients With Type 2 Diabetes Mellitus.

    abstract：PURPOSE:It is unclear whether vitamin D provides any benefit against the pro-inflammatory effects of homocysteine in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:We compared lymphocyte counts for CD3, CD19, CD4, and CD8 subsets between elderly (age ≥65 years) T2DM patients (n = 5098) and nondiabetes ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2020.08.009

    authors： Ma C,Zhao Y,Liu Z

    更新日期：2020-10-01 00:00:00

  • Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris.

    abstract：:A four-week crossover study to compare the efficacy of an acne cleanser containing 2% salicylic acid with that of a 10% benzoyl peroxide wash was conducted in 30 patients with acne vulgaris. The results demonstrated that only patients treated with the salicylic acid cleanser had a significant reduction in comedones. P...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Shalita AR

    更新日期：1989-03-01 00:00:00

  • Twenty-eight-day oral contraceptives: physician and user attitudes.

    abstract：:A 28-day regimen of oral contraceptives that uses seven iron tablets (each containing 75 mg of ferrous fumarate) instead of seven sugar placebos was designed to encourage user compliance. To determine professional and user attitudes toward the 28-day regimen, 192 obstetrician-gynecologists and 469 women who used oral ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Richards-Brandt M

    更新日期：1988-01-01 00:00:00

  • The Effect of Intravenous Dexamethasone on the Nausea Accompanying Vestibular Neuritis: A Preliminary Study.

    abstract：PURPOSE:We undertook a preliminary assessment of the efficacy of administering intravenous dexamethasone (DEX) for relieving the nausea and dizziness accompanying vestibular neuritis (VN). METHODS:Between November 2013 and October 2014, 26 patients with VN were prospectively enrolled in this study. The patients were r...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2015.09.010

    authors： Kim JC,Cha WW,Chang DS,Lee HY

    更新日期：2015-11-01 00:00:00

  • Trends in off-label beta-blocker use: a secondary data analysis.

    abstract：BACKGROUND:The off-label use of beta-blockers might be prevalent, but no studies have provided empiric data on the off-label use based on utilization data. OBJECTIVE:This secondary data analysis was conducted to describe the trends of off-label use of beta-blockers among ambulatory visits made to office-based physicia...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2006.10.015

    authors： Lin HW,Phan K,Lin SJ

    更新日期：2006-10-01 00:00:00

  • Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: evidence from a meta-analysis.

    abstract：BACKGROUND:Rates of patient adherence (compliance) to pharmacotherapy range from <5% to >90%. Negative determinants include multiple daily dosing (MDD), chronic duration, and asymptomatic disease. Reports suggest that once-daily (QD) dosing may improve adherence, but their findings are inconclusive. OBJECTIVE:The purp...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1016/s0149-2918(02)85026-3

    authors： Iskedjian M,Einarson TR,MacKeigan LD,Shear N,Addis A,Mittmann N,Ilersich AL

    更新日期：2002-02-01 00:00:00

  • Efficacy of budesonide in inhaled corticosteroid-naive patients and patients with mild persistent asthma.

    abstract：BACKGROUND:Patients with mild intermittent or mild persistent asthma represent 70% of asthma sufferers. Inhaled corticosteroids (ICSs) are the mainstay of treatment for persistent asthma, although many of the early clinical studies of these drugs included only patients with moderate to severe asthma. OBJECTIVE:This ar...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-2918(02)80017-0

    authors： Eigen H

    更新日期：2002-07-01 00:00:00

  • A cost comparison of alternative regimens for treatment-refractory partial seizure disorder: an econometric analysis.

    abstract：BACKGROUND:Partial seizure disorder is typically treated by monotherapy with antiepileptic drugs (AEDs). However, when the condition is refractory to the initial treatment regimen, patients may be switched to monotherapy with another AED or to combination therapy with the initial AED plus a second AED. OBJECTIVES:The ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2005.10.020

    authors： Lee WC,Hoffmann MS,Arcona S,D'Souza J,Wang Q,Pashos CL

    更新日期：2005-10-01 00:00:00

  • Relationship between adherence to daily nicotine patch use and treatment efficacy: secondary analysis of a 10-week randomized, double-blind, placebo-controlled clinical trial simulating over-the-counter use in adult smokers.

    abstract：BACKGROUND:It has been reported that the efficacy of acute forms of nicotine replacement therapy, such as nicotine gum and lozenges, improves when sufficient quantities of medication are used. OBJECTIVE:This analysis examined whether adherence with daily nicotine patch wear was associated with improved rates of smokin...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2008.09.016

    authors： Shiffman S,Sweeney CT,Ferguson SG,Sembower MA,Gitchell JG

    更新日期：2008-10-01 00:00:00

  • Ondansetron for nausea and vomiting associated with moderately emetogenic cancer chemotherapy.

    abstract：:This multicenter, randomized, double-blind study compared the efficacy and tolerability of ondansetron 8 mg twice daily for 3 days with placebo in preventing nausea and vomiting in 81 patients receiving cyclophosphamide-doxorubicin-based chemotherapy. The first dose of study drug was administered 30 minutes before the...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0149-2918(95)80087-5

    authors： DiBenedetto J Jr,Cubeddu LX,Ryan T,Kish JA,Sciortino D,Beall C,Eisenberg PD,Henderson C,Griffin D,Wentz A

    更新日期：1995-11-01 00:00:00

  • Progress Report on Neglected Tropical Disease Drug Donation Programs.

    abstract：PURPOSE:Neglected tropical diseases (NTDs) impose a significant burden on public health, particularly in developing nations. Many can be treated cost-effectively with drugs donated or offered at or below marginal cost. In 2012, the World Health Organization published an NTD roadmap that outlined a strategy for the prev...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/j.clinthera.2016.02.031

    authors： Cohen JP,Silva L,Cohen A,Awatin J,Sturgeon R

    更新日期：2016-05-01 00:00:00

  • An examination of the effect of cytochrome P450 drug interactions of hydroxymethylglutaryl-coenzyme A reductase inhibitors on health care utilization: a Canadian population-based study.

    abstract：BACKGROUND:Cytochrome P450-related drug interactions can lead to adverse effects that may affect health care resource utilization. OBJECTIVE:The purpose of this study was to quantify the impact of drug interactions involving hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) on health care resource utiliz...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/s0149-2918(02)80102-3

    authors： Einarson TR,Metge CJ,Iskedjian M,Mukherjee J

    更新日期：2002-12-01 00:00:00

  • Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects.

    abstract：BACKGROUND:Vitamin B12 (cobalamin) deficiency may be caused by inadequate dietary intake of B12 or by conditions that result in malabsorption of the vitamin. Crystalline vitamin B12, usually in the form of cyanocobalamin, is administered parenterally (ie, intramuscularly) or orally for treating deficiency states. Intra...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinthera.2011.05.088

    authors： Castelli MC,Wong DF,Friedman K,Riley MG

    更新日期：2011-07-01 00:00:00

  • Neuromodulation for the Treatment of Epilepsy: A Review of Current Approaches and Future Directions.

    abstract：PURPOSE:Neuromodulation holds great promise for the treatment of drug-resistant epilepsy. This article reviews the most common types of neuromodulation as well as potential future applications of preclinical techniques such as optogenetics. This review serves as a reference for treating neurologists on the latest scien...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2020.05.017

    authors： Davis P,Gaitanis J

    更新日期：2020-07-01 00:00:00

  • In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens.

    abstract：:Macrolide and beta-lactam antimicrobial agents are frequently used for the treatment of upper and lower respiratory tract infections and skin or skin structure infections. To evaluate the relative in vitro activity of these antimicrobial drugs against organisms commonly involved in these infections, we tested clarithr...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Ritchie DJ,Hopefl AW,Milligan TW,Byrne JE,Maddux MS

    更新日期：1993-01-01 00:00:00

  • Aripiprazole in schizophrenia and schizoaffective disorder: A review.

    abstract：BACKGROUND:During the past decade, there has been some progress in the pharmacotherapy of schizophrenia and schizoaffective disorder. Current evidence supports the use of various second-generation, or atypical, antipsychotic medications, although few of these agents have been associated with long-term efficacy and tole...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2010.01.021

    authors： Stip E,Tourjman V

    更新日期：2010-01-01 00:00:00

  • Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials.

    abstract：BACKGROUND:Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease caused by mutations in the survival motor neuron gene (SMN1) and the leading genetic cause of infant mortality. Currently, there is no effective treatment other than supportive care. OBJECTIVE:This article provides a general overvi...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinthera.2013.11.006

    authors： Zanetta C,Nizzardo M,Simone C,Monguzzi E,Bresolin N,Comi GP,Corti S

    更新日期：2014-01-01 00:00:00

  • Effects of olopatadine hydrochloride nasal spray 0.6% in the treatment of seasonal allergic rhinitis: a phase III, multicenter, randomized, double-blind, active- and placebo-controlled study in adolescents and adults.

    abstract：BACKGROUND:Seasonal allergic rhinitis (SAR) is an allergen-induced inflammatory reaction that occurs during periods of high pollen count. Current treatments for SAR include allergen avoidance, systemic antihistamines, and steroidal and nonsteroidal intranasal sprays. Olopatadine is a selective antihistamine and an inhi...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.clinthera.2009.01.016

    authors： Shah SR,Nayak A,Ratner P,Roland P,Michael Wall G

    更新日期：2009-01-01 00:00:00

  • Use of direct thrombin inhibitors in acute coronary syndrome.

    abstract：OBJECTIVE:This paper examines the rationale for using direct thrombin inhibitors in the management of acute coronary syndrome (ACS). BACKGROUND:With traditional management of ACS using aspirin and unfractionated heparin (UH), refractory angina and new myocardial infarction (MI) continue to develop. Growing understandi...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1016/S0149-2918(00)80065-X

    authors： Nemergut C,Cheng JW

    更新日期：2000-08-01 00:00:00

  • The origin of bacteria isolated from patients after transurethral prostatectomy.

    abstract：:Of 250 patients undergoing transurethral prostatectomy, 34 had significant bacteriuria after surgery. In 20 patients, including some without significant colonies of bacteria, the same organisms were found before surgery. Closed surgical systems and aseptic techniques can prevent infection from outside the patient, but...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Fujita K

    更新日期：1988-01-01 00:00:00

  • Effects of an Extract of Salmon Milt on Symptoms and Serum TNF and Substance P in Patients With Fibromyalgia Syndrome.

    abstract：PURPOSE:The aim of this study was to evaluate the effects of a dietary supplement containing primarily an extract of salmon's milt (semen) on symptoms and blood levels of proinflammatory molecules in patients with fibromyalgia syndrome (FMS), a chronic, painful musculoskeletal disease without a distinct pathogenesis or...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.clinthera.2019.05.019

    authors： Tsilioni I,Pipis H,Freitag MSC,Izquierdo MDC,Freitag K,Theoharides TC

    更新日期：2019-08-01 00:00:00

  • A pharmacokinetic and clinical review of the potential clinical impact of using different formulations of cyclosporin A. Berlin, Germany, November 19, 2001.

    abstract：:A meeting of 14 transplant and pharmacokinetic specialists from Europe and North America was convened in November 2001 to evaluate scientific and clinical data regarding the use of different formulations of cyclosporin A (CsA). The following consensus was achieved. (1) CsA is a critical-dose drug with a narrow therape...

    journal_title：Clinical therapeutics

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1016/s0149-2918(03)80161-3

    authors： Pollard S,Nashan B,Johnston A,Hoyer P,Belitsky P,Keown P,Helderman H,CONSENT: Consensus on Substitution in European Transplantation.

    更新日期：2003-06-01 00:00:00

  • Ensuring health care quality: a purchaser's perspective--a health care coalition.

    abstract：:This paper explores how one health care purchasing coalition in Minnesota, the Buyers Health Care Action Group (BHCAG), has taken an active role in restructuring its local health care market. BHCAG started with the belief that the consumer should be the motivating force in health care delivery. Unfortunately, providin...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Robinow A

    更新日期：1997-11-01 00:00:00

  • Impact of transfer from animal-source insulins to biosynthetic human insulin (rDNA E coli) in patients with diabetes mellitus.

    abstract：:Six hundred forty-eight patients (50.5% men; 49.5% women) with diabetes mellitus on animal-source insulin therapy for at least five years were studied. In this patient population, approximately 68.7% had Type I insulin-dependent diabetes mellitus and 31.3% had Type II noninsulin-dependent diabetes mellitus, nonetheles...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：

    authors： Garber AJ,Davidson JA,Krosnick A,Beaser RS,Anderson JH Jr

    更新日期：1991-09-01 00:00:00

  • Single-blind comparison of cinoxacin and nitrofurantoin in the treatment of urinary tract infection.

    abstract：:A single-blind comparison was undertaken to evaluate 250 mg of cinoxacin and 100 mg of nitrofurantoin, both drugs being given four times a day, for the treatment of urinary tract infections. Complete data are available from 58 patients, most of whom were treated for 10 to 15 days. The clinical response was similar in ...

    journal_title：Clinical therapeutics

    pub_type： 临床试验,杂志文章

    doi：

    authors： Schneider RE

    更新日期：1982-01-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of aztreonam administered by continuous intravenous infusion.

    abstract：:The pharmacodynamic parameter that appears to correlate best with a successful therapeutic outcome with beta-lactam antibiotics is the length of time the serum antibiotic concentration remains above the minimum inhibitory concentration (MIC) for the infecting pathogen. By maximizing this parameter, continuous administ...

    journal_title：Clinical therapeutics

    pub_type： 杂志文章

    doi：10.1016/S0149-2918(00)86736-3

    authors： Burgess DS,Summers KK,Hardin TC

    更新日期：1999-11-01 00:00:00