Abstract:
OBJECTIVE:The aim of this research letter was to describe the use of N-carbamoyl-L-glutamate as first-line treatment of hyperammonemia in a 4-month-old female patient with propionic acidemia (PA). METHODS:A 4-month-old female patient weighing 3.9 kg presented with decompensation with PA and initial hyperammonemia of 451 microg/dL. The patient was receiving a protein-restricted diet supplemented with L-carnitine at a dosage of 100 mg/kg/d during 2 consecutive months. Treatment with N-carbamoyl-L-glutamate was administered during 4 days on an outpatient basis at a dosage of 100 mg/kg/d, representing a dosage of 200 mg BID. The patient's hyperammonemia was monitored for 1 week. RESULTS:The patient's ammonia concentration started to decrease on the first day of the initiation of the treatment with N-carbamoyl-L-glutamate, from 451 to 68 microg/dL (normal range, 10-80 microg/dL) at day 6 of follow-up. The patient did not require intravenous fluids, invasive procedures, or hospitalization. CONCLUSION:N-carbamoyl-L-glutamate, combined with a protein-restricted diet and L-carnitine supplementation, was apparently effective as first-line treatment of hyperammonemia in this infant with PA.
journal_name
Clin Therjournal_title
Clinical therapeuticsauthors
Soyucen E,Demirci E,Aydin Adoi
10.1016/j.clinthera.2010.04.004subject
Has Abstractpub_date
2010-04-01 00:00:00pages
710-3issue
4eissn
0149-2918issn
1879-114Xpii
S0149-2918(10)00128-1journal_volume
32pub_type
杂志文章abstract:OBJECTIVE:The objectives of this study were to observe a commercially insured sample diagnosed with a venous thromboembolism (VTE) event and treated postevent with warfarin and to detail the thromboembolic and bleeding outcomes in the time periods during warfarin therapy and after discontinuation of such therapy. METH...
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更新日期:1980-01-01 00:00:00
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更新日期:2008-08-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2000-11-01 00:00:00