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Pharmacokinetic profile of cisapride 20 mg after once- and twice-daily dosing.

Abstract：

:Cisapride is a substituted piperidinyl benzamide. It is chemically related to metoclopramide but lacks the antidopaminergic properties of metoclopramide that affect the central nervous system and cause extrapyramidal side effects. Cisapride is indicated for the symptomatic treatment of patients with nocturnal heartburn due to gastroesophageal reflux disease. Based on extensive assessment of the drug's pharmacokinetic profile, the currently approved initial oral dosing regimen for cisapride is 10 mg QID. However, the pharmacokinetics of cisapride after oral administration of 20 mg BID have not been investigated. We present here findings from an open-label trial assessing the pharmacokinetics of cisapride 20-mg tablets after a single dose and at steady state (BID dosing). The results indicate that 20-mg BID and 10-mg QID regimens produce similar steady-state concentrations.

journal_name

Clin Ther

journal_title

Clinical therapeutics

authors

Zhou H,Herron J,Clyde C,Lee P,Mechlinski W,Pesco-Koplowitz L

doi

10.1016/s0149-2918(98)80092-1

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

292-8

issue

2

eissn

0149-2918

issn

1879-114X

pii

S0149-2918(98)80092-1

journal_volume

20

pub_type

临床试验,杂志文章

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