当前位置： SCI文献检索 > CLINICAL THERAPEUTICS期刊下所有文献 > The efficacy of two doses of omeprazole for short- and long-term peptic ulcer treatment in the elderly.

The efficacy of two doses of omeprazole for short- and long-term peptic ulcer treatment in the elderly.

Abstract：

:This study evaluated the efficacy, safety, and most suitable dose of omeprazole in short-term acute treatment (4 weeks) and maintenance treatment (6 months) of patients older than 60 years of age with endoscopically diagnosed gastric ulcer (GU) or duodenal ulcer (DU). This randomized, prospective study included 156 patients (67 GU and 89 DU; mean age, 74.8 and 72.3 years, respectively) who were randomized in the acute phase into two treatment groups: omeprazole 20 mg/d or 40 mg/d as a single morning dose for 4 weeks. The 6-month follow-up phase included 101 patients who were randomized to receive omeprazole 20 mg/d or 20 mg every other day. After 4 weeks of treatment, 94.0% of GU patients and 95.5% of DU patients showed complete ulcer scarring with no statistical differences between doses. At the end of the 6-month follow-up, 4.5% of GU patients and 8.8% of DU patients relapsed, with no statistical differences between groups. No clinically significant adverse events were recorded. In conclusion, omeprazole is a highly effective, well-tolerated, and safe drug for the short- and long-term treatment of GU and DU in the elderly. The dose of 20 mg/d for the acute phase and 20 mg on alternate days for maintenance therapy appears most appropriate for elderly patients with ulcers.

journal_name

Clin Ther

journal_title

Clinical therapeutics

authors

Pilotto A,Di Mario F,Battaglia G,Vigneri S,Leandro G,Franceschi M,De Boni M,Grasso A,Vianello F,Naccarato R

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

935-41

issue

6

eissn

0149-2918

issn

1879-114X

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CLINICAL THERAPEUTICS文献大全