Lipid modulation and systemic inflammation.

Abstract:

:N-6 and n-3 PUFAs from the diet are absorbed and reach the cell where they interact with fatty acid binding proteins within cell membranes and cytoplasm. They are processed in the endoplasmic reticulum (desaturation-elongation reactions, lipid synthesis, eicosanoid and epoxide production) and in peroxisomes (beta-oxidation, synthesis, oxidation products). They interact with receptors, ion channels, and nuclear elements; the result is modulation of gene expression. PUFA-induced alterations result in modulation of local and systemic inflammation and inflammatory disease activity.

journal_name

Crit Care Clin

journal_title

Critical care clinics

authors

Zaloga GP,Marik P

doi

10.1016/s0749-0704(05)70160-3

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

201-17

issue

1

eissn

0749-0704

issn

1557-8232

pii

S0749-0704(05)70160-3

journal_volume

17

pub_type

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