Abstract:
BACKGROUND:To retrospectively compare the clinical outcome in cervical cancer patients treated by external irradiation and intracavitary high-dose rate (HDR) brachytherapy with iridium 192 versus low-dose rate (LDR) brachytherapy with radium 226 or caesium 139. METHODS:450 LDR patients were treated from 1982 to 1986 and compared with 189 HDR patients treated from 1993 to 1999. Cobalt (CO) 60 treatment was replaced in the HDR group by modern megavoltage photon radiotherapy (Linac 25 MV). Brachytherapy was given in either 2 or 3 LDR radium 226 implants for the earlier patient cohort, and 3-6 HDR iridium 192 implants for the latter cohort. The primary endpoint assessed was the 3-year overall survival. RESULTS:The median duration of follow-up was 70 months (range, 2-108 months) in the LDR group and 34 months (range, 4-69 months) in the HDR group. Actuarial overall 3-year survival after conventional LDR brachytherapy was 51.3%, versus 58.2% after HDR brachytherapy. No difference in 3-year survivors was seen in the small groups of stage I (68.3% vs. 84.6%) and stage IV (23.1% vs. 37.5%) patients. In stage II and III and in the overall group there were statistically significantly more 3-year survivors in the HDR group (58.1% vs. 78.9%, p < 0.001 in stage II; 37.3% vs. 53.8%, p < 0.01 in stage III; and 46.7% vs. 67.2%, p < 0.001 in the total group). Retrospectively assessed complication rates in the former LDR group were 3.8% for irreversible side effects, and 13.3% for chronic radiation damage. In the HDR group the actuarial late complication rates for grades 3 and 4 were 2.9% for the bladder, 4.0% for the bowel, and 6.1% for the rectum. CONCLUSION:In our preliminary experience, HDR brachytherapy combined with external beam radiation produced similar and even better survival rates compared with the LDR series. HDR brachytherapy combined with external beam radiation is an efficient method for the treatment of cervical cancer and adverse side effects are comparable.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Kucera H,Pötter R,Knocke TH,Baldass M,Kucera Esubject
Has Abstractpub_date
2001-01-15 00:00:00pages
58-62issue
1-2eissn
0043-5325issn
1613-7671journal_volume
113pub_type
杂志文章abstract::In contrast to intravenously-administered crystallene glucagon, which acts for 20 minutes only, the depot form, zinc protamine glucagon, shows a prolonged haemodynamic action. Fourteen patients with pre-existing heart failure received a single dose of 20 mg Zn protamine glucagon intramuscularly. The stroke volume and ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1979-01-19 00:00:00
abstract:BACKGROUND AND AIMS:The impact of hemodialysis on liver stiffness is still unclear. The aim of the study was to assess liver fibrosis by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to quantify the influence of net fluid withdrawal on liver stiffness during one hemodialysis session. The second aim ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-019-01577-w
更新日期:2019-11-28 00:00:00
abstract:BACKGROUND:The practice of inappropriate medication and drug prescription is a major risk factor for adverse drug reactions in geriatric patients and increases the individual, as well as overall, rates of hospital admissions, resulting in increased health care expenditures. A consensus-based list of drugs, generally to...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-011-0061-5
更新日期:2012-03-01 00:00:00
abstract::The decrease in blood viscosity induced by streptokinase (SK) in the present investigation in proportional to the streptokinase concentration up to a concentration of 2000 IE/ml blood. A maximum decrease in viscosity is attained with a dosage of between 200 and 300 IE/ml blood. The decrease in viscosity is already cle...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-05-13 00:00:00
abstract::A product combining 25 mg hydrochlorothiazide, 2.5 mg amiloride hydrochloride and 10.0 mg timolol maleate (Moducrin) was tested in 20 previously untreated hypertensive persons. The systolic blood pressure before treatment was 199.1 +/- 24.8 mmg Hg and after treatment 149.1 +/- 19.1 mm Hg. Diastolic blood pressure show...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1981-08-07 00:00:00
abstract::Within recent years female sterilization has gained a place of great importance as an effective contraceptive method. Nowadays sterilization is hardly subject to any formal restrictions, but is solely the responsibility of the woman concerned, the couple or the physician. The indications for sterilization may be divid...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1987-11-06 00:00:00
abstract::IgM (Immunoglobin M) antibodies to the antigen T (Thomsen-Friedenreich antigen, transformation antigen) were detected by normal agglutination technique in the serum of 7 out of 73 newborn children. Neither the mother's anti-T titre, nor the quantity of IgM and IgG (Immunoglobulin G) in the sera of mother and child was...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1982-08-06 00:00:00
abstract::Idiopathic bronchiolitis obliterans organizing pneumonia (idiopathic BOOP) and idiopathic CD4+ T lymphocytopenia are syndromes of unknown origins which have been characterized in recent years. An important feature of both syndromes is the good prognosis. The clinical and histological features of idiopathic BOOP are un...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Cervical re-exploration in persistent medullary thyroid cancer usually fails to normalize serum calcitonin levels, which is the most sensitive criterion of tumour-free status (2 out of 21 patients in our re-exploration series). Positive lymph nodes - even at an early tumour stage - seem much more important (postoperat...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1988-05-27 00:00:00
abstract::In view of the observation of tonic-clonic convulsions after the use of Propanidid in certan patients, a study was undertaken of the effects of this drug (7 mg/kg) on the EEG of 2 volunteers with a known history of epilepsy. Both subjects developed tonic-clonic convulsions and showed typical alterations of the EEG pat...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-04-04 00:00:00
abstract::The Zollinger-Ellison syndrome is characterized pathophysiologically by a significant hypergastrinemia derived from a gastrin-secreting neuroendocrine tumor with a primary location in the pancreas or duodenum. Chronic hypergastrinemia in turn triggers gastric acid hypersecretion yielding in chronic or recurrent or ref...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-007-0884-2
更新日期:2007-01-01 00:00:00
abstract::Hepatitis delta virus (HDV) is a pathogenic and transmissible virus which requires the helper function of hepatitis B virus for its replication. Epidemiological studies have shown that HDV infection is distributed world-wide, with a higher prevalence in southern areas, especially in Italy. HDV may increase the severit...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::We report our initial experience with pulmonary function testing in neonates during intensive care, using an automated, computerized system (PEDS), which allows non-invasive and rapid determination of pulmonary mechanics and energetics such as compliance, resistance and respiratory drive, and measurement of lung volum...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The principle of the ultrasound examination of the heart is explained and the possible applications of this method are discussed. Three case histories are presented to exemplify the usefulness of echocardiography in clinical cardiology. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-06-24 00:00:00
abstract::The pharmacodynamic interaction between lumefantrine and its monodesbutyl analogue (DBB) has been investigated in 35 fresh isolates of Plasmodium falciparum. Both compounds showed highly significant activity correlation. The geometric mean values for complete inhibition of schizont maturation (GMCOC) were 536,8 nM for...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-008-1080-8
更新日期:2008-01-01 00:00:00
abstract::The present study aimed at elucidating lytic effector cell function in 32 schizophrenic patients and comparing the results with data obtained in 27 normal probands. Natural killer cell (NK) activity and antibody dependent cellular cytotoxicity (ADCC) were tested. Schizophrenics did not differ from normal controls in e...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1988-06-10 00:00:00
abstract::The purpose of the present study was to examine the heat building up in the pulp cavity during superficial laser preparation, to examine the tooth surface structure at the area treated by laser and to assess the possible duration of treatment on the basis of the rate of tissue removal. Following laser application, a s...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Midodrine, which is used in the treatment of hypotensive circulatory distrubances was investigated with respect to possible effects on carbohydrate and fat metabolism in 5 healthy subjects and 7 patients with disturbed glocuse tolerance. An i.v. glucose tolerance test was carried out on both groups and was repeated a ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-03-04 00:00:00
abstract::A review and discussion of the incidence and clinical importance of various cardiac arrhythmias in patients with inflammatory diseases of the heart is presented in this paper. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-08-15 00:00:00
abstract:BACKGROUND:Femoral short stems promise essential advantages in total hip arthroplasty. Up to now, only short- and midterm clinical studies exist. Data on early stem migration that could predict later aseptic loosening at an early stage are rare. The purpose of this study was to assess migration patterns and clinical ou...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-015-0756-0
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The aim of this retrospective single center cohort study was to assess the occurrence of bradycardia during implantable loop recorder (ILR) monitoring in patients with unexplained syncope and negative conventional testing and to identify clinical predictors of bradycardia and pacemaker implantation. METHODS...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-017-1197-8
更新日期:2017-07-01 00:00:00
abstract::33 kidney tumours were detected in 15,500 routine scans of the upper abdomen. 13.7 per cent of these tumours were asymptomatic at the time of diagnosis. The size of these accidentally detected tumours was evidently smaller than in the case of symptomatic ones and the patients were younger at the time of diagnosis. The...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1987-12-18 00:00:00
abstract::Ulcerative colitis occurs before the age of 15 years in 20% and before 20 years in 40% of all patients involved. The frequency of this disease in patients at the University Children's Hospital of Munich has clearly risen over the past years. In many patients we found characteristic differences in history, clinical pic...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1986-08-29 00:00:00
abstract:OBJECTIVE:Our aim was to evaluate the usefulness of screening for cardiovascular risk factors and the effect of applying professional guidelines for risk reduction in postmenopausal women, as judged by the Framingham and the high-risk systematic coronary risk evaluation (SCORE) methods. METHODS:18 menopause clinics in...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章
doi:10.1007/s00508-009-1152-4
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Transient elastography (TE) is a noninvasive tool to assess hepatic fibrosis by measuring liver stiffness (LS). Recent studies suggest that TE may be used to screen for liver cirrhosis and clinically significant portal hypertension (≥ 10 mmHg; CSPH), whereas data on the clinical applicability of TE are limit...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-012-0190-5
更新日期:2012-06-01 00:00:00
abstract::The inhibitory effect of somatostatin on the secretion of glucagon permits the examination of the effect of glucagon on some metabolic parameters in the insulin-dependent diabetic patient. The results obtained in 5 insulin-dependent diabetics and in 4 pancreatectomized patients revealed an inhibitory effect of somatos...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1976-09-03 00:00:00
abstract::This study analyses the efficacy of a consistent, strict follow-up programme in the management of patients with gastric cancer. Between 1978 and 1986 671 patients were treated, of whom 361 (54%) had a radical operation. The data were fed into an electronic data base and patients were invited to attend the follow-up in...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1987-06-12 00:00:00
abstract:AIMS:The functional effect of the pineal gland cyst is difficult to evaluate with visual field examination. The aim of this study is to investigate the usefulness of visual evoked potentials (VEP) in patients with pineal gland cyst due to the possible compression on the visual pathway. SUBJECTS AND METHODS:Black-and-w...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-012-0215-0
更新日期:2012-09-01 00:00:00
abstract::Poliomyelitis, an infectious disease with acute and persistent flaccid paralysis is caused by poliovirus (types 1, 2 or 3), an enterovirus. The infection is asymptomatic in 95% of infected subjects. Most of the paralytic cases occur in adolescents or adults in the course of polio type 1 infection. In the prevaccinatio...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-30 00:00:00
abstract::Epidemiological studies strongly imply that smoking is a risk factor for back problems. The question arises as to the nature of the underlying pathomechanism. Several theories are currently discussed in the literature: it could be due to "unhealthy" life styles associated with smoking, to a rise in intraabdominal pres...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00