[The effect of propanidid in patients with an increased tendency to cerebral convulsions (author's transl)].

Abstract:

:In view of the observation of tonic-clonic convulsions after the use of Propanidid in certan patients, a study was undertaken of the effects of this drug (7 mg/kg) on the EEG of 2 volunteers with a known history of epilepsy. Both subjects developed tonic-clonic convulsions and showed typical alterations of the EEG pattern even before the onset of hyperventilation. These EEG alterations were producible also during complete relaxation. The convulsions were easily stopped by the administration of short-acting barbiturates. Similar observations reported in the literature are briefly discussed. The conclusion is drawn that Propanidid should not be given to patients with a known history of epilepsy or any other convulsive disease.

journal_name

Wien Klin Wochenschr

authors

Tschakaloff C,Draxler V,Sporn P,Sunder-Plassmann M

subject

Has Abstract

pub_date

1975-04-04 00:00:00

pages

252-4

issue

7

eissn

0043-5325

issn

1613-7671

journal_volume

87

pub_type

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