Acute pandysautonomia--restitutio ad integrum by high prednisolone therapy.

Abstract:

:Acute pandysautonomia is a rare disease defined as acute widespread and severe sympathetic and parasympathetic failure and sparing of somatic nerve fibers. The causes of this syndrome are often an autoimmune disease leading to autonomic ganglionopathy. The majority of cases have a poor prognosis with a chronic debilitating course. We present a previously healthy 24-year-old female patient, who developed a loss of accommodation, pupillotonia, lacrimation, swallowing disturbances, gastrointestinal symptoms and an atonic bladder with 750 ml residual volume. The Ewing battery showed signs of parasympathetic and sympathetic dysfunction leading to the diagnosis of acute pandysautonomia. Further tests failed to find a cause of acute neuropathy especially where there was no evidence for paraneoplastic or infectious etiology. The patient was treated with high dose intravenous prednisolone and completely recovered.

journal_name

Wien Klin Wochenschr

authors

Struhal W,Hödl S,Mazhar S,Ransmayr G

doi

10.1007/s00508-011-0030-z

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

508-11

issue

15-16

eissn

0043-5325

issn

1613-7671

journal_volume

123

pub_type

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