The significance of colonic mucosal lymphoid hyperplasia and aphthoid ulcers in Crohn's disease.

Abstract:

OBJECTIVE:To access concordance between radiological severity of aphthae and the more advanced features of Crohn's disease. PATIENTS AND METHODS:In 75 patients with an established diagnosis of Crohn's disease, we evaluated the radiological severity of colonic aphthae by meticulous double-contrast radiography. The degree of aphthae was defined as follows: AE0 = no lesions; AE1 = small nodules without barium flecks (lymphoid hyperplasia); AE2 = minute barium flecks < or = 1 mm in size with a translucent halo (umbilical or eroded lymphoid hyperplasia); AE3 = barium flecks varying from 2 mm to 5 mm in size (typical aphthoid ulcerations). We compared the degree of the lesions to the disease activity, and reviewed these sequential changes during a mean interval of 10 months. RESULTS:AE3 lesions were more prevalent than AE1 or AE2 lesions in patients with active colitis. AE1 or AE2 lesions were found regardless of the involved bowel sites or the disease activity. Of 44 patients receiving a nutritional diet, 26 patients showed regression of the lesions although most of the patients still exhibited AE1 or AE2 lesions. In two of eight patients without the treatment, the lesions progressed. CONCLUSION:In Crohn's disease, development of aphthoid ulcers is associated with disease activity; lymphoid hyperplasia may exist independently of disease activity.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Hizawa K,Iida M,Aoyagi K,Fujishima M

doi

10.1016/s0009-9260(96)80243-1

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

706-8

issue

10

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(96)80243-1

journal_volume

51

pub_type

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