Seizures during lithium-amitriptyline therapy.

Abstract:

:Epileptiform seizures occurred in a 34-year-old woman who was receiving amitriptyline and lithium carbonate therapy for treatment of endogenous depression. While receiving amitriptyline maintenance therapy, she was given lithium on two separate occasions, and despite serum levels of lithium in the therapeutic range, grand mal seizures developed. The seizures may represent a toxic reaction either to lithium or to combined drug therapy. Controlled studies are needed to evaluate both the efficacy and toxicity of combined drug therapy in affective disorders.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Solomon JG

doi

10.1080/00325481.1979.11715252

subject

Has Abstract

pub_date

1979-09-01 00:00:00

pages

145-6, 148

issue

3

eissn

0032-5481

issn

1941-9260

journal_volume

66

pub_type

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