Abstract:
:Cidofovir is a nucleotide analogue which inhibits viral DNA polymerase and is effective against human cytomegalovirus (CMV) infection. It is phosphorylated to its active form by cellular enzymes. With the long intracellular half-life of its metabolites, cidofovir can be administered weekly during induction and every other week during maintenance therapy. Viral resistance has not been documented in patients treated with cidofovir to date, but has developed in vitro. Immediate cidofovir therapy delayed progression of CMV retinitis compared with deferred treatment in patients with AIDS. Cidofovir also delayed the progression of CMV retinitis relapsing after previous treatment. To avoid nephrotoxicity, probenecid and intravenous saline hydration must be administered with each dose of cidofovir.
journal_name
Drugsjournal_title
Drugsauthors
Lea AP,Bryson HMdoi
10.2165/00003495-199652020-00006subject
Has Abstractpub_date
1996-08-01 00:00:00pages
225-230; discussion 231issue
2eissn
0012-6667issn
1179-1950journal_volume
52pub_type
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