Exercise and sensory integration. Role of the nucleus tractus solitarius.

Abstract:

:Since NTS neurons receive synaptic input from many sensory modalities, it is crucial to understand the neuronal mechanisms involved in synaptic processing. We have proposed that GABA-containing neurons in the NTS are the primary target for somatic afferent fibers activated by skeletal muscle contraction. In our model, local inhibition of baroreceptor signaling is necessary to counteract the increase in baroreceptor input such that NTS output is normalized and baroreflex sensitivity is maintained during exercise. This GABAergic mechanism, in conjunction with sympathoexcitation evoked by somatic afferents, preserves reflex sensitivity and resets the baroreflex, respectively. Unfortunately, there is insufficient data to date to support or refute the proposed role for GABA on baroreflex function during exercise. However, we feel that this model will be useful in formulating future experiments to explore these synaptic interactions.

journal_name

Ann N Y Acad Sci

authors

Potts JT

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

221-36

eissn

0077-8923

issn

1749-6632

journal_volume

940

pub_type

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