Abstract:
:Orthotopic partial liver transplantation (PLT) models were developed in rats to explore the unique role of the liver in transplant tolerance. In PVG rats, syngeneic PLT established that surgical reduction to one-third of the liver and orthotopic transplantation permitted survival. Allogeneic PLT in the PVG to DA liver-tolerant model, both 50% and 33%, did not affect the tolerogeneic property of the liver, with all PLT recipients surviving indefinitely. Blood samples taken at various time points for detection of donor cells using flow cytometry showed a steady increase in donor cell chimerism in both PLT and whole liver transplantation (WLT) recipients that persisted throughout the 3-month observation period. At each time point, the level of donor cell chimerism in PLT was higher than that in WLT. We conclude that transplantation of one-third of the liver is compatible with survival in rats. Reduction of antigenic load by means of hepatectomy does not affect the tolerogenic effect of the liver in the PVG to DA LT model because of the remarkable regeneration capability of the liver. Peripheral chimeric levels increase progressively after WLT, suggesting that this is an ongoing immunological phenomenon. The earlier and increased chimerism after PLT may be associated with liver regeneration.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Sun J,Qin G,Wu L,Wang C,Sheil AGdoi
10.1002/micr.1036subject
Has Abstractpub_date
2001-01-01 00:00:00pages
183-7issue
4eissn
0738-1085issn
1098-2752pii
10.1002/micr.1036journal_volume
21pub_type
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