Improved techniques for kidney transplantation in mice.

Abstract:

:Improved microsurgical techniques for kidney transplantation in the mouse are described. Left renal transplantation is performed with end-to-side anastomoses of the donor renal vein to the inferior vena cava and the donor aortic cuff to the aorta. Urinary tract reconstruction is accomplished by suturing the donor ureter with a bladder patch to the recipient bladder. With these modifications, it is possible to achieve success rates as high as 90%. This stable and reproducible model provides a useful tool to study the immunological mechanisms of kidney allograft rejection at the molecular level.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Zhang Z,Schlachta C,Duff J,Stiller C,Grant D,Zhong R

doi

10.1002/micr.1920160212

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

103-9

issue

2

eissn

0738-1085

issn

1098-2752

journal_volume

16

pub_type

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