Arterial crush injury causes decrease in tissue perfusion at the level of the microcirculation in skeletal muscle flap.

Abstract:

:This study was designed to evaluate the effects of crush injuries to the feeding arteries of a muscle flap on microcirculatory haemodynamics. Eighteen male Sprague-Dawley rats were divided into three experimental groups for intravital microscopy of the cremaster muscle flap. Group 1 served as control. In group 2 the common iliac artery and in group 3 additionally the lower abdominal aorta was crushed with a Kocher clamp (17.4 N) over 5 min. Microcirculatory parameters (red blood cell velocity, vessel diameter, and capillary perfusion) were monitored before and 2 h after crush. In the one-level crush group, red blood cell velocities significantly decreased by 39.17% (P=0.046) in first order arterioles and by 32. 91% (P=0.0106) in second order arterioles. In capillary perfusion, a drop of 48.02% (P=0.0039) was noted. In the two-level crush group, red blood cell velocities significantly dropped over 32.06% (P=0. 0250) in first order arterioles, 35.91% (P=0.0065) in second order arterioles, and 45.69% (P=0.0782) in first order venules. Capillary perfusion was reduced by 20.16% (P=0.374). Arterial crush injuries as possible thrombogenic insults may result in a significant decrease in skeletal muscle perfusion although the blood supply through the crushed supplying vessel is maintained.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Krapohl BD,Mailänder P,Siemionow M,Giunta R,Zins JE

doi

10.1002/(sici)1098-2752(1999)19:8<364::aid-micr3>3

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

364-8

issue

8

eissn

0738-1085

issn

1098-2752

pii

10.1002/(SICI)1098-2752(1999)19:8<364::AID-MICR3>3

journal_volume

19

pub_type

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