Abstract:
:Using 9-12-month-old Lewis rats, our laboratory performed consecutive organ transplantations to assess the technical feasibility and observe the histopathologies of prolonged transplants and implants over a rat's life span. This study includes a total of 688 cases of consecutive syngeneic organ transplantation, including pancreaticoduodenum (PD), en-bloc liver-pancreaticoduodenum-spleen-stomach (LPdSpSt), and spleen bearing ovary or testicle. A 52-month-old consecutively transplanted pancreas showed normal acini and islet cells. Consecutively transplanted LPdSpSt cases at 25-28 months preserved normal histology. After 26.5 months of ovarian follicle implantation into the spleen, the pathology of the organ exhibited typical dysgerminoma. However, 29.5-month-old infantile testicle implants in the spleen showed seminoma. Our studies suggest that transplanted organs can be reusable and retransplanted, and we hope this could be one of the clues to solve donor-organ shortages in the future.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Lee S,Hong IC,Yoo CH,Nam S,Bai S,Pivetti C,Kim KK,Emmanuel G,Kim JJ,D'Silva M,Wang Y,Nozawa M,Lee D,Niewiadomski S,Yoon JH,Jung SI,Wolf P,Gittes RFdoi
10.1002/micr.20138subject
Has Abstractpub_date
2005-01-01 00:00:00pages
403-9issue
5eissn
0738-1085issn
1098-2752journal_volume
25pub_type
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