Consecutive organ transplantation in inbred rats: long-term results--Are organs recyclable?

Abstract:

:Using 9-12-month-old Lewis rats, our laboratory performed consecutive organ transplantations to assess the technical feasibility and observe the histopathologies of prolonged transplants and implants over a rat's life span. This study includes a total of 688 cases of consecutive syngeneic organ transplantation, including pancreaticoduodenum (PD), en-bloc liver-pancreaticoduodenum-spleen-stomach (LPdSpSt), and spleen bearing ovary or testicle. A 52-month-old consecutively transplanted pancreas showed normal acini and islet cells. Consecutively transplanted LPdSpSt cases at 25-28 months preserved normal histology. After 26.5 months of ovarian follicle implantation into the spleen, the pathology of the organ exhibited typical dysgerminoma. However, 29.5-month-old infantile testicle implants in the spleen showed seminoma. Our studies suggest that transplanted organs can be reusable and retransplanted, and we hope this could be one of the clues to solve donor-organ shortages in the future.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Lee S,Hong IC,Yoo CH,Nam S,Bai S,Pivetti C,Kim KK,Emmanuel G,Kim JJ,D'Silva M,Wang Y,Nozawa M,Lee D,Niewiadomski S,Yoon JH,Jung SI,Wolf P,Gittes RF

doi

10.1002/micr.20138

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

403-9

issue

5

eissn

0738-1085

issn

1098-2752

journal_volume

25

pub_type

杂志文章
  • Radial forearm flap plus Flexor Carpi Radialis tendon in Achilles tendon reconstruction: Surgical technique, functional results, and gait analysis.

    abstract:BACKGROUND:Wound dehiscence, infection, and necrosis of tendon and overlying skin are severe complications after open repairs of Achilles tendon. A simultaneous reconstruction should be provided in a single stage operation. We evaluated the outcomes of one of the possible options: the radial forearm free flap with Flex...

    journal_title:Microsurgery

    pub_type: 临床试验,杂志文章

    doi:10.1002/micr.22481

    authors: Innocenti M,Tani M,Carulli C,Ghezzi S,Raspanti A,Menichini G

    更新日期:2015-11-01 00:00:00

  • Effect of hyperbaric oxygen on pedicle flaps with compromised circulation.

    abstract::The effect of hyperbaric oxygen (HBO) on the survival rate of experimental rat pedicle island flaps with arterial, venous, and combined arteriovenous insufficiency was evaluated. Forty male Wistar rats with pedicle island flaps were divided into four groups with different types of vascular status. Another 40 male Wist...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22004

    authors: Ulkür E,Yüksel F,Açikel C,Celiköz B

    更新日期:2002-01-01 00:00:00

  • Reconstruction after resection of tumors around the knee: role of the free vascularized fibular graft.

    abstract::We present our experience with reconstruction after resection of tumors around the knee, using free vascularized fibular grafting. The study included 23 patients. The lower femur was involved in 17 cases, the upper tibia in 6. The cases included giant cell tumor of the lower femur (2 patients), giant cell tumor of the...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/1098-2752(2000)20:5<233::aid-micr4>3.0.co;

    authors: Amr SM,El-Mofty AO,Amin SN,Morsy AM,El-Malt OM,Abdel-Aal HA

    更新日期:2000-01-01 00:00:00

  • Antigenic load and peripheral chimeric levels in entire and partial liver allograft recipients.

    abstract::Orthotopic partial liver transplantation (PLT) models were developed in rats to explore the unique role of the liver in transplant tolerance. In PVG rats, syngeneic PLT established that surgical reduction to one-third of the liver and orthotopic transplantation permitted survival. Allogeneic PLT in the PVG to DA liver...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1036

    authors: Sun J,Qin G,Wu L,Wang C,Sheil AG

    更新日期:2001-01-01 00:00:00

  • Persistent genital arousal disorder: Treatment by neurolysis of dorsal branch of pudendal nerve.

    abstract:BACKGROUND:Persistent genital arousal disorder (PGAD) is a woman's perception that she is in a state of sexual arousal, without the ability of arousal to be satisfied by orgasm. It is the hypothesis of this study that PGAD results from a minimal degree of nerve compression of the dorsal branch of the pudendal nerve. If...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30464

    authors: Klifto K,Dellon AL

    更新日期:2020-02-01 00:00:00

  • The radial forearm free flap as a "vascular bridge" for secondary microsurgical head and neck reconstruction in a vessel-depleted neck.

    abstract:BACKGROUND:In a vessel-depleted neck, distant recipient sites may be the only option for secondary free flap reconstruction. While interposition vein grafts and arteriovenous loops can bridge the gap between the recipient and donor pedicle, they are not without risks. In these scenarios, we examinate the reliablity of ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30259

    authors: Ciudad P,Agko M,Date S,Chang WL,Manrique OJ,Huang TCT,Lo Torto F,Trignano E,Chen HC

    更新日期:2018-09-01 00:00:00

  • Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats.

    abstract::Both hypotension and hypertension aggravate the damage of reperfusion injury after reconstructive microsurgery. The purpose of this study is to establish a theoretical guide for postoperative blood pressure control in optimizing the cutaneous perfusion and flap survival. Systemic arterial pressure was altered by the i...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20627

    authors: Sun TB,Kuo TB,Yang CC

    更新日期:2009-01-01 00:00:00

  • Microvascular replantation in a seven-month-old girl: a case report.

    abstract::Replantation of an amputated digit in a child demands special techniques for success. Our experiences with replantation in this age group have shown that although these patients have a lower viability rate after digital replantation, those digits that do survive develop excellent function. In this case report of a 7-m...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920090308

    authors: Gaul JS 3rd,Nunley JA

    更新日期:1988-01-01 00:00:00

  • Vascularized periosteal graft from the first metatarsal bone: a new technique to prevent collapse of osteonecrosis of the talus in children. A case report.

    abstract::Several microsurgical techniques have been described for the treatment of osteonecrosis of the talus (ONT). Recently reported in children, vascularized periosteal grafts showed promising revascularizing properties. We report a novel technique using a pedicled periosteal graft from the first metatarsal bone to treat st...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22045

    authors: Soldado F,Barrera-Ochoa S,Fontecha CG,Haddad S,Barastegui D,Barber I,Rego P

    更新日期:2013-01-01 00:00:00

  • Use of the latissimus dorsi flap in head and neck reconstructive microsurgery.

    abstract::Reconstructive surgery of the head and neck has particularly benefited from the rapid developments in microsurgery. Resection of tumours from the head and neck which are associated with serious physical and psychological problems, or which often require multiple reconstructive procedures, can now be performed as a sin...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920150711

    authors: Papadopoulos ON,Gamatsi IE

    更新日期:1994-01-01 00:00:00

  • Free and island flap transfer for soft tissue defects in the hand and forearm.

    abstract::Two hundred twenty patients with soft tissue defects in the hand and forearm were treated with 226 free and island flap transfers. Reconstructed sites involved the thumb in 74 cases, the fingers in 117, the hand in 30, and the forearm in 5. Seventy-nine patients received 82 free flaps, and 141 patients received 144 is...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/(SICI)1098-2752(1996)17:3<150::AID-MICR10>

    authors: Yajima H,Tamai S,Fukui A,Ono H,Inada Y

    更新日期:1996-01-01 00:00:00

  • A more versatile and reliable method for renal transplantation in the rat.

    abstract::This study describes the authors' experience with a new method of orthotopic renal transplantation in the rat. This technique combines previously described modifications with the use of the donor inferior vena cava as a conduit to perform an end-to-side venous anastomosis. Survival was 87% and 80% at 3 and 120 days, r...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/(sici)1098-2752(1998)18:4<267::aid-micr10>

    authors: Blom D,Orloff MS

    更新日期:1998-01-01 00:00:00

  • Application of Kunlin's technique in vascular micro-anastomosis: experimental and clinical study.

    abstract::Vascular microanastomosis of vessels that presents marked discrepancy in size can be performed without difficulty by making a longitudinal incision of the end of the smallest vessel, forming a kind of "spatula," and joined to the vessel of greater diameter. ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920060111

    authors: Fossati E,Asurey N,Irigaray A

    更新日期:1985-01-01 00:00:00

  • The distally based, venous supercharged anterolateral thigh flap.

    abstract::The distally-based anterolateral thigh flap is an attractive option for proximal leg and knee coverage but venous congestion is common. Restoration of antegrade venous drainage via great saphenous vein supercharge to the proximal flap vein is proposed. The purpose of this study was to evaluate and compare outcomes of ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22380

    authors: Lin CH,Zelken J,Hsu CC,Lin CH,Wei FC

    更新日期:2016-01-01 00:00:00

  • Effects of some pharmacological agents on the survival of unipedicled venous flaps: an experimental study.

    abstract::Clinical and experimental studies have been conducted to improve the survival of venous flaps. As a result of these studies, although various survival mechanisms were raised, none obtained satisfactory information. Venous stasis, and the resultant venous thrombosis, is a factor that decreases the survival of venous fl...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.21801

    authors: Askar I,Saray A,Gurlek A,Sevin K,Sabuncuoglu BT

    更新日期:2001-01-01 00:00:00

  • Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle.

    abstract::This study examines the effects of combination therapy with the nitric oxide (NO) donor S-nitroso-N-acetylcysteine (SNAC) and the iNOS inhibitor N-(3-(aminomethyl)benzyl) acetamidine (1400W) on contractile function in reperfused rat skeletal muscle. The right extensor digitorum longus (EDL) muscles of 104 rats were su...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20122

    authors: Barker JU,Qi WN,Cai Y,Urbaniak JR,Chen LE

    更新日期:2005-01-01 00:00:00

  • Influence of neck dissection and preoperative irradiation on microvascular head and neck reconstruction-Analysis of 853 cases.

    abstract:BACKGROUND:Previous neck dissection and irradiation is believed to affect the success of free tissue transfers in head and neck reconstruction, but evidence is scarce and conflicting. This study seeks to evaluate flap success rates in the presence of these two factors. METHODS:Over a ten-year period, a total of 853 fr...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.22270

    authors: Tan NC,Lin PY,Chiang YC,Chew KY,Chen CC,Fujiwara T,Kuo YR

    更新日期:2014-11-01 00:00:00

  • Improved techniques for kidney transplantation in mice.

    abstract::Improved microsurgical techniques for kidney transplantation in the mouse are described. Left renal transplantation is performed with end-to-side anastomoses of the donor renal vein to the inferior vena cava and the donor aortic cuff to the aorta. Urinary tract reconstruction is accomplished by suturing the donor uret...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920160212

    authors: Zhang Z,Schlachta C,Duff J,Stiller C,Grant D,Zhong R

    更新日期:1995-01-01 00:00:00

  • Microsurgery for lymphedema: clinical research and long-term results.

    abstract:OBJECTIVES:To report the wide clinical experience and the research studies in the microsurgical treatment of peripheral lymphedema. METHODS:More than 1800 patients with peripheral lymphedema have been treated with microsurgical techniques. Derivative lymphatic microvascular procedures recognize today its most exemplar...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20737

    authors: Campisi C,Bellini C,Campisi C,Accogli S,Bonioli E,Boccardo F

    更新日期:2010-05-01 00:00:00

  • Physiologic alteration of fibrinogen levels: influence upon patency of microvenous anastomoses.

    abstract::High baseline levels of plasma fibrinogen have been correlated with increased risk for cardiovascular disease. Since fibrinogen plays a central role in both coagulation and platelet aggregation and is a primary component of thrombi, this study was designed to assess the relationship of circulating fibrinogen concentra...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920130603

    authors: Cooley BC,Fowler JD,Gould JS

    更新日期:1992-01-01 00:00:00

  • Clinical outcomes of a simultaneous replantation technique for amputations of four or five digits.

    abstract:PURPOSE:Replantation of amputations separated by more than four digits is challenging microsurgery because of the technical demands and long operation time. The purpose of this report was to present the clinical and functional outcomes in patients with amputations of four or five digits using a simultaneous replantatio...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30009

    authors: Kwon GD,Ahn BM,Lee JS,Park YG,Ha YC

    更新日期:2016-03-01 00:00:00

  • Neuropathological changes in vibration injury: an experimental study.

    abstract::Vibration syndrome, a clinical condition arising from chronic use of vibrating tools, is associated with a spectrum of neurovascular symptoms. To date, only its vascular pathology has been extensively studied; we sought to determine what direct neurologic injury, if any, is caused by vibration. Hindlimbs of anesthetiz...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20081

    authors: Matloub HS,Yan JG,Kolachalam RB,Zhang LL,Sanger JR,Riley DA

    更新日期:2005-01-01 00:00:00

  • The periosteal-cutaneous chimeric medial femoral condyle free flap for subtotal ear reconstruction: A case report.

    abstract::When costal graft is contraindicated or refused by the patient, autologous total/subtotal auricular reconstruction represent a real challenge as limited surgical options has been described. Aim of present report is to offer a novel possible autologous reconstruction of the ear frame using a chimeric free medial femora...

    journal_title:Microsurgery

    pub_type:

    doi:10.1002/micr.30657

    authors: di Summa PG,Sapino G,Zaugg P,Raffoul W,Guillier D

    更新日期:2020-10-01 00:00:00

  • Management of osteonecrosis of the femoral head with pedicled iliac bone flap transfer: A multicenter study of 2190 patients.

    abstract:BACKGROUND:Osteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction of the hip joint and disabling arthritis. Several procedures have been developed to arrest the progress of osteonecrosis and postpone the procedure of total hip replacement especially in young patients. The ai...

    journal_title:Microsurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1002/micr.30195

    authors: Zhao D,Xie H,Xu Y,Wang Y,Yu A,Liu Y,Wang A,He W,Wang X,Li Z,Sun W,Tian S,Wang B,Liu B

    更新日期:2017-11-01 00:00:00

  • Short communication: distal adrenergic innervation remains normal after perivascular sympathectomy.

    abstract::Perivascular sympathectomy, which has been used for vasospastic disorders of the hands, was examined in experimental models. Perivascular sympathectomy was performed on the central ear vessels and forepaw metacarpal vessels of the rabbit and on the common digital vessels in the monkey. The effects on adrenergic nerves...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920150113

    authors: Kaarela OI,Raatikainen TK,Junila JA,Waris TH

    更新日期:1994-01-01 00:00:00

  • Carcinogenesis in reflux disease--in search for bile-specific effects.

    abstract::Bile reflux may play a key role for esophageal carcinogenesis in reflux disease. In search for bile-specific effects, the animal model of esophageal cancer was applied in a mutagenesis assay. Big Blue transgenic mice were operated with microsurgical techniques. Seven had total gastrectomy with esophagojejunostomy crea...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.20424

    authors: Fein M,Peters JH,DeMeester TR

    更新日期:2007-01-01 00:00:00

  • Aberrant position of the ulnar nerve within the carpal canal.

    abstract::A case is presented where both the ulnar nerve and palmaris profundus tendon were found within the carpal tunnel during routine open decompression for carpal tunnel syndrome. ...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.10196

    authors: Papanastasiou S,Sood M

    更新日期:2004-01-01 00:00:00

  • Tendocutaneous free flap transfer from the dorsum of the foot.

    abstract::Tendocutaneous free flap transfer has been used to treat troublesome wounds involving skin and tendons, with the dorsum of the foot being the most frequent donor site. Free flaps consist of the dorsalis pedis artery, saphenous vein, branch of the superficial peroneal nerve, long extensor tendons, and overlying skin. W...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920151211

    authors: Lee KS,Park SW,Kim HY

    更新日期:1994-01-01 00:00:00

  • Double nerve transfer for restoring external rotation of the glenohumeral joint after neonatal brachial plexus injury.

    abstract:INTRODUCTION:The probability of spontaneous recovery of shoulder external rotation in neonatal brachial plexus injury (NBPI) is very low after the age of 18 months. We report the outcomes of double nerve transfers to restore active external rotation of the glenohumeral joint in children with NBPI after this age. PATIE...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.30616

    authors: Soldado F

    更新日期:2020-11-01 00:00:00

  • Experimental study and clinical observations on hypertrophy of vascularized bone grafts.

    abstract::In order to understand the mechanisms involved in the hypertrophy of vascularized bone grafts, a series of animal experiments were carried out and 32 clinical cases were studied. A defect in the tibial shaft was created in puppies and the ipsilateral fibula was transferred into the medullary cavity of the tibia with t...

    journal_title:Microsurgery

    pub_type: 杂志文章

    doi:10.1002/micr.1920151012

    authors: Fujimaki A,Suda H

    更新日期:1994-01-01 00:00:00