Abstract:
:Nerve regeneration using artificial biodegradable conduits is of increasing interest. The aim of this study is to evaluate the regeneration and maturation of a nerve after long-term implantation (2 years) of a biodegradable poly-L-lactide/poly-epsilon-caprolactone (PLLA/PCL) copolymeric nerve guide in the sciatic nerve of the rat. After harvesting, we evaluated both the regenerated nerves and the controls, using light microscopy, transmission electron microscopy, and morphometric techniques. Remnants of biomaterial were still present after 2 years of implantation, but the foreign body reaction was very mild at this stage, due to the rounded shapes of the polymer debris. Morphometric analysis showed significant differences between the regenerated nerve and the normal sciatic nerve: the number of myelinated fibers is higher, and the mean fiber diameter of the myelinated fibers in the regenerated nerve is smaller. In conclusion, the results demonstrate that the new PLLA/PCL nerve guide can provide optimal conditions for regeneration and maturation of damaged nerves.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Den Dunnen WF,Van der Lei B,Schakenraad JM,Blaauw EH,Stokroos I,Pennings AJ,Robinson PHdoi
10.1002/micr.1920140808subject
Has Abstractpub_date
1993-01-01 00:00:00pages
508-15issue
8eissn
0738-1085issn
1098-2752journal_volume
14pub_type
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