Abstract:
:The controlled adsorptive accumulation of Zn(II)-terfenadine complex (1:1) onto a hanging mercury drop electrode (HMDE) provides the basis for determination of the antihistamine drug terfenadine by differential pulse cathodic adsorptive stripping voltammetry. The adsorbed Zn(II)-terfenadine complex (1:1) at the HMDE developed a stripping voltammetry peak at more negative potential than that of the free Zn(II) ions. The peak current was used for the determination of terfenadine in pharmaceutical formulation and human plasma in 0.1 mol l(-1) sodium perchlorate solution under the optimized conditions (E(acc), -0.5 V; t(acc) 360 s; scan rate, 5 mV s(-1) and pulse height 100 mV). The developed peak current (i(p)) showed a linear dependence with terfenadine concentration within the range of 6 x 10(-8) - 9 x 10(-7) mol l(-1). The recoveries were found 98.97-99.35%, 99.72-99.02% and 100.58-101.08% with the R.S.D. 0.16-0.27%, 0.25-0.82% and 0.44-1.14% in authentic form, pharmaceutical formulations and human plasma, respectively. The detection limits were 0.4505 and 0.6115 ng ml(-1) terfenadine in pharmaceutical formulations and human plasma, respectively.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Ghoneim M,Issa R,Tawfik Adoi
10.1016/s0731-7085(01)00491-5subject
Has Abstractpub_date
2001-11-01 00:00:00pages
593-8issue
4eissn
0731-7085issn
1873-264Xpii
S0731-7085(01)00491-5journal_volume
26pub_type
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