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Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry.

Abstract：

:A novel HPLC-MS/MS method was developed for the quantitative determination of 1-deoxynojirimycin (DNJ), a potent glucosidase inhibitor present in mulberry leaves (Morus alba L.). DNJ was isolated from the mulberry leave extract on a TSKgel Amide-80 column using a mixture of 0.1% formic acid and acetonitrile as a mobile phase at a flow rate of 0.6 ml/min. A triple quadrupole mass spectrometry using electrospray ionization source in a positive ion mode under multiple reaction monitoring with the [M+H]+ ions, m/z 164.4/109.9 was used. The detection limit (S/N=3) was 75 pg and quantitation limit (S/N=10) was 100 pg. The comparison of mulberry leaves of different ages showed that the DNJ level was higher in mulberry shoots than young and mature leaves.

journal_name

J Pharm Biomed Anal

journal_title

Journal of pharmaceutical and biomedical analysis

authors

Nuengchamnong N,Ingkaninan K,Kaewruang W,Wongareonwanakij S,Hongthongdaeng B

doi

10.1016/j.jpba.2007.03.031

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

853-8

issue

4

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(07)00195-1

journal_volume

44

pub_type

杂志文章

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