Indirect parameters of pancreatic function in cystic fibrosis (CF) during a controlled double-blind trial of pancreatic supplementation.

Abstract:

:During two treatment periods (4 weeks each), serum immunoreactive trypsin (IRT), immunoreactive human lipase in stool (IRL), and chymotrypsin (CT) activity in stool were determined in 16 cystic fibrosis patients and compared with fecal fat excretion (72-h sampling). Fecal fat estimation revealed mild to severe steatorrhea in all 16 patients (X = 13.7 +/- 9.0 g/24 h) in at least one study period. Stool fat excretion was highest in underweight adolescents and adults. Comparison of IRT and IRL with stool fat values showed no significant statistical correlation. IRT values revealed an inverse exponential correlation with age, with a steep decline at the age of 5 years. CT levels were very high in 14 of our 16 patients during supplementation therapy, whereas 2 patients showed subnormal CT values. We conclude that since indirect parameters of pancreatic function do not correlate with stool fat excretion, stool fat remains the best indirect parameter for the assessment of pancreatic insufficiency in cystic fibrosis. Leaving pancreatic enzyme supplementation in cystic fibrosis patients on the basis of normal serum trypsin or fecal lipase values does not appear to be adequate.

authors

Regele S,Henker J,Münch R,Barbier Y,Stern M

doi

10.1097/00005176-199601000-00011

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

68-72

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1991-04-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

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    更新日期:1989-07-01 00:00:00

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    pub_type: 共识发展会议,杂志文章

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    pub_type: 杂志文章

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