Abstract:
:We describe the findings in nine Asian-Indian patients with gelatinous droplike corneal dystrophy (GDCD). Most patients showed initial signs of bilateral decreased vision and photophobia at an early age. The siblings were affected in four cases, and parental consanguinity was recorded in seven cases. We classified the disease into three forms based on clinicopathologic findings. Clinically, the mild form of the disease was evidence by central subepithelial, whitish-yellow, nodular lesions that corresponded to the subepithelial nodular deposits seen histologically. In the moderate form, the lesions coalesced, forming central, diffuse subepithelial lesions with superficial vascularization. On histology, the amyloid deposits assumed a sheetlike distribution in the subepithelial regions and in the superficial stroma. Aggregates of chronic inflammatory cells and stromal neovascularization were seen in the adjacent stroma. The severe form presented as diffuse, whitish opacification of the cornea with extensive neovascularization and scarring. Histologically this form was characterized by a visible plaque of vascularized scar tissue that partly replaced the stroma and enveloped the amyloid deposits. Frequent, early recurrence of the disease was noted in the grafts. This study provides a detailed clinicopathologic description of GDCD from the Indian subcontinent. We also discuss previously unreported findings from the most advanced stage of the disease.
journal_name
Corneajournal_title
Corneaauthors
Li S,Edward DP,Ratnakar KS,Reddy M,Tso MOdoi
10.1097/00003226-199607000-00004subject
Has Abstractpub_date
1996-07-01 00:00:00pages
355-62issue
4eissn
0277-3740issn
1536-4798journal_volume
15pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To assess the endothelial cell loss after cataract extraction using a fluid-based system and compare it with conventional ultrasound. METHODS:A total of 46 eyes of 23 patients with up to 3+ bilateral cataract were included. The first eye was randomized to either fluid-based system or conventional ultrasound, a...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ico.0000226366.64796.20
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:To report a case of corneal ulceration and perforation after PRK connected with high doses of ketorolac tromethamine (Acula). METHODS:A 31-year-old man presented 5 days after PRK in the left eye with corneal ulceration and perforation requiring penetrating keratoplasty. The patient admitted to using Acular eve...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000179931.05275.dd
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To identify potential donor, recipient, surgical, and postoperative factors that may influence survival and visual outcome of penetrating keratoplasty (PKP). METHODS:As part of a prospective longitudinal study, the electronic records of the New Zealand National Eye Bank were analyzed for the 10-year period fro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182014668
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/01.ico.0000247219.18295.5e
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To report on surgical reduction of oculodermal melanosis in 6 patients presenting with severe episcleral pigmentation. METHODS:After informed consent was obtained, surgical reduction of ocular pigmentation with ocular dermal melanosis was performed on 3 children, 2 girls and 1 boy male, who were cosmetically h...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000151546.00489.c9
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To compare efficiency and safety of epithelium-off corneal cross-linking (CXL) and transepithelial cross-linking (TE-CXL) in pediatric patients with progressive keratoconus. METHODS:Uncorrected and corrected visual acuity, corneal topography and pachymetry (Pentacam; Oculus Pentacam), and in vivo confocal micr...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31826cf32d
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To determine the effect of intravitreal injection of ranibizumab on the corneal endothelium in patients with choroidal neovascularization in age-related macular degeneration. METHODS:Observational prospective case series study. Fifty-two eyes of 52 consecutive patients (29 men, 23 women; age range, 61-80 years...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ca33d2
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:To describe the effect of the corneal asphericity and toricity on the map patterns and best fit sphere (BFS) characteristics in elevation topography. METHODS:The corneal surface was modeled as a biconic surface of principal radii and asphericity values of r1 and r2 and Q1 and Q2, respectively. The apex of the ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181fb4fa7
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To establish a time-proven "gold standard" in modified osteoodontokeratoprosthesis (OOKP) surgery. METHODS:The OOKP is the procedure of choice for restoring sight in patients with corneal blindness caused by end-stage ocular surface disease not amenable to penetrating keratoplasty. Members of the OOKP Study Gr...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000157401.81408.62
更新日期:2005-11-01 00:00:00
abstract::An evaluation of the final "sutures out" postoperative astigmatism in two groups of keratoconus patients undergoing penetrating keratoplasty is presented. Group I consists of a retrospective evaluation of keratoconus patients who underwent penetrating keratoplasty without using the Troutman Keratometer prior to suturi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199309000-00005
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:To assess the use of serial computed tomography (CT) in the detection of osteo-odonto-lamina resorption in osteo-odonto-keratoprosthesis (OOKP) and to investigate the use of new volumetric software, Advanced Lung Analysis software (3D-ALA; GE Healthcare), for detecting changes in OOKP laminar volume. METHODS:A...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31825425d0
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:We report 2 cases in which cataract extraction with a foldable acrylic toric intraocular lens (IOL) implantation was used to correct (irregular) corneal astigmatism in patients with keratoconus and cataract. METHODS:Case 1 was a 78-year-old man with cataract and keratoconus in the left eye. He underwent phacoe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31820009d4
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To assess the difference between endothelial cells from tissues preserved in media supplemented with fetal bovine serum (FBS) and recombinant human serum albumin (rHSA). METHODS:In a donor-matched study, 48 tissues were preserved for 28 days at 31°C in Cornea Max and Cornea Syn supplemented with FBS and rHSA, ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002097
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To assess the morphologic differences of three types of lattice corneal dystrophies (LCDs) from histologic, immunohistochemical, and ultrastructural studies. METHODS:Corneas from three patients, one LCD1, one His626Arg-LCD, and one LCD3A were processed for Congo red, betaig-h3(541-564) antibodies immunostainin...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200207000-00006
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to report the successful medical management of 2 cases of late-onset endothelial keratoplasty-related stromal interface infections. METHODS:All cases of endothelial keratoplasty-related infections treated with intrastromal antifungal injections were compiled. The following information...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000192
更新日期:2014-09-01 00:00:00
abstract::Twelve FITC-conjugated lectins were used to establish a reaction pattern with cellular and noncellular components in fresh-frozen and formalin-fixed paraffin sections of 11 normal human corneas. In frozen sections the epithelium demonstrated the most active lectin staining; keratocytes and endothelium stained to a les...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To evaluate if donor corneas obtained from deaths occurring because of septicemia can be used for corneal transplantation. STUDY DESIGN:Prospective study. METHODS:Eleven septicemic donor corneas were used in the study and 10 donor corneas from deaths because of causes other than septicemia were used as contro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000858
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the visual function information obtained from multiple reading tests in a dry eye population. METHODS:In this case-control, single-center clinical research center-based study, 15 subjects with dry eye (mean age 65 years) and 10 normal subjects (mean age 40 years) were incl...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000490
更新日期:2015-08-01 00:00:00
abstract::Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluor...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199111000-00009
更新日期:1991-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine whether long-term wear of a fluid-filled scleral lens alters basal tear production, corneal sensation, corneal nerve density, and corneal nerve morphology in 2 disease categories. METHODS:Patients recruited from the Prosthetic Replacement of the Ocular Surface Ecosystem (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000381
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To describe the clinical and in vivo confocal microscopic findings of the cornea in 2 male siblings with Maroteaux-Lamy syndrome. METHODS:Two male siblings 27 and 22 years of age who had been diagnosed with Maroteaux-Lamy syndrome underwent ophthalmologic assessment. In vivo confocal microscopy of their cornea...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31802be383
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To describe a case of Beauveria bassiana keratitis and to discuss the management of this rare condition. METHODS:An 82-year-old woman underwent surgical repair of a graft wound dehiscence. Seven months later, shortly after the removal of sutures, the patient developed a fungal keratitis. B. bassiana was identi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200005000-00031
更新日期:2000-05-01 00:00:00
abstract::Penetrating keratoplasty is currently the only treatment for corneal endothelial dysfunction. Although corneal transplantation has a high success rate, a few problems still remain, such as the limited availability of donor grafts, the change in refraction after penetrating keratoplasty, and the higher chance of immune...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199403000-00011
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:To investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls. METHODS:Tears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational d...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181f22cd9
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To investigate the long-term clinical course of scleromalacia with calcified plaque as a complication of cosmetic conjunctivectomy with topical mitomycin C (MMC) application and to introduce a surgical method for this complication using calcified plaque removal and/or conjunctival flap surgery. METHODS:Eleven ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318277ac92
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To compare anterior segment spectral-domain optical coherence tomography (OCT) with eye bank technician slit-lamp examination (SLE) in characterizing lesions in donor corneas. METHODS:Twenty-nine donor corneas identified by eye bank technicians to have opacities or lesions potentially representing pathologic f...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001700
更新日期:2018-10-01 00:00:00
abstract::Here we report a new method for image analysis of the corneal stroma. To obtain the biometric characteristics of a given area, we perform three different treatments of the same image. These automated predictions closely match each parameter (length, surface area, etc.), as measured manually by a "blind investigator." ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199107000-00009
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To examine the role of epithelial cells in inducing the differentiation of keratocytes into myofibroblasts and to determine whether this effect may be inhibited by amniotic membrane matrix. METHODS:In vivo, a 9-mm diameter, partial-thickness corneal flap was created in 12 rabbit eyes (6 rabbits), which were eq...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200103000-00019
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To describe the Oxford Scheme for grading ocular surface staining in dry eye and to discuss optimization of stain detection using various dyes and filters. Also, to propose a sequence of testing for dry eye diagnosis. METHODS:The grading of corneal and conjunctival staining is described, using the Oxford Schem...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200310000-00008
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To report the outcome and the reversibility of refractive outcomes after intrastromal corneal ring segment (ICRS) explantation in patients with keratoconus treated with ICRS implantation and same-day collagen crosslinking (CXL). METHODS:This is a retrospective review of ICRS explantation in 3 eyes of 3 patient...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182a738ba
更新日期:2013-12-01 00:00:00