[Evaluation of the sensitization power of Montenegro skin test].

Abstract:

:The Montenegro skin test, used to diagnose cutaneous leishmaniasis, is now being considered to detect immunogenicity after vaccination. In this study, we evaluated the ability of this test to induce immune response and IFN-g production in subjects not previously exposed to Leishmania. The Montenegro skin test was performed using antigens of L. amazonensis produced by our laboratory (group I) or by FIOCRU-RJ (group II). At day 30, 33% of the subjects from group I and 42% from group II were positive, compared to 67% from group I and 50% from group II at day 90. IFN-y was detected in 56 % of subjects from group I and 17% from group II at day 30 (169+/-309 and 11+/-36pg/ml) and in 67% from group I and 58% from group II by day 360 (69+/-107 and 18+/-20pg/ml). These data demonstrate that the Montenegro skin test induces not only a delayed hypersensitivity reaction, but also IFN-y production.

journal_name

Rev Soc Bras Med Trop

authors

José FF,da Silva IM,Araújo MI,Almeida RP,Bacellar O,Carvalho EM

doi

10.1590/s0037-86822001000600007

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

537-42

issue

6

eissn

0037-8682

issn

1678-9849

pii

S0037-86822001000600007

journal_volume

34

pub_type

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