Abstract:
BACKGROUND:P-selectin, an adhesion molecule of the selectin family, is expressed on the surface of activated thrombocytes by thrombin. The aim of the present study was to assess the predictive value of P-selectin (estimated by flow cytometric assay) for acute cardiac events in acute coronary syndrome. METHODS:The study consisted of 48 patients with acute coronary syndrome and 30 healthy control subjects. After immediate fixation with 1% paraformaldehyde, 50 microliters of this aliquot was incubated with phycoerythrin-CD62-related antigen, and then measured by flow cytometry. The short-term clinical course of the patients was compared with their P-selectin values. RESULTS:The average P-selectin values in the 30 healthy volunteers was 0.11 +/- 0.20% (range, 0.0-0.5%). Significant differences were observed between acute cardiac events in patients with unstable angina and high P-selectin values and those with normal P-selectin values (chi 2 = 4.3; P < 0.05). Moreover, the angina patients who experienced acute cardiac events had significantly elevated P-selectin values (2.1 +/- 2.3%) compared with patients who did not experience acute cardiac events (0.3 +/- 0.4%, P < 0.05). The P-selectin values were elevated in seven out of 24 patients who suffered acute myocardial infarction. Seven of the 14 patients with acute coronary syndromes and high P-selectin values required urgent percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG), or both, otherwise they developed extension of the infarction. However, only five of the 34 patients with normal P-selectin values required urgent PTCA or CABG. Significant differences were observed in acute cardiac events between the high P-selectin and normal P-selectin groups (chi 2 = 4.8, P < 0.05). CONCLUSION:High P-selectin values indicate activation of platelets and the risk of acute cardiac events in patients with acute coronary syndrome.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Itoh T,Nakai K,Ono M,Hiramori Kdoi
10.1097/00019501-199508000-00009subject
Has Abstractpub_date
1995-08-01 00:00:00pages
645-50issue
8eissn
0954-6928issn
1473-5830journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Both experimental and pathological studies suggest that immune response and inflammation may play an important role in the pathogenesis of coronary spasm. DESIGN:To elucidate the role of systemic immune and inflammatory responses in the pathogenesis of coronary spasm, we studied circulating T-lymphocyte act...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200205000-00005
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify psychosocial variables that, in addition to known medical factors, predict the long-term outcome after a first myocardial infarction. PATIENTS AND METHODS:The study population consisted of 222 men aged 30-60 years who entered an inpatient rehabilitation program a mean o...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199502000-00009
更新日期:1995-02-01 00:00:00
abstract::This review provides a brief introduction to the basic concepts of MRA techniques with specific discussions on imaging of coronary arteries. These techniques, especially those for imaging of coronary arteries, are still rapidly evolving. The goals of future research include obtaining faster imaging, higher SNR, and hi...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-199905000-00002
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Although underlying mechanisms of coronary artery ectasia (CAE) are clearly unknown, destruction of extracellular matrix may be responsible for the ectasia formation. Thus, we investigated the role of matrix metalloproteinases (MMP), tissue inhibitor of matrix metalloproteinases (TIMP-1), and inflammatory mar...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283109079
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:We analyzed a large patient group to develop a clinical risk score that could be applied to patients after primary percutaneous coronary intervention (PCI). METHODS:We reviewed 2529 consecutive patients treated with primary PCI for ST-elevation myocardial infarction between 2003 and 2008. All clinical, angi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328333f528
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to describe the procedural characteristics, myocardial perfusion, and long-term outcomes in ST-elevation myocardial infarction patients with an ectatic infarct-related artery (IRA). PATIENTS AND METHODS:The retrospective analysis included 1270 consecutive ST-elevation myocardial inf...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000720
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000194
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000873
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Coronary artery bypass graft (CABG) surgery has been a mainstream surgical procedure for coronary artery disease for the past three decades. 64-Slice coronary computed tomographic angiography (CCTA) has been established as an accurate alternative to invasive coronary artery angiography for postoperative evalu...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32834b830e
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS:SMC were isolated by...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00011
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Experimental and clinical studies have suggested that intracoronary infusion of bone marrow-derived stem/progenitor cells (BMC) may improve left ventricular function after acute myocardial infarction (AMI). We conducted a systematic review and meta-analysis to investigate the efficacy and safety of BMC thera...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MCA.0b013e328300dbd3
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Lipoprotein (a) [Lp(a)] is an independent risk factor for coronary artery disease and niceritrol (a prodrug of nicotinic acid) is known to reduce Lp(a) levels. Patients with coronary artery disease often have impairment of the fibrinolytic system. METHODS:To elucidate the effect of niceritrol on fibrinolysi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199602000-00012
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests. OBJECTIVES:We attempted to perform selective spasm provocation tests to examine the incidence of provoked spasm in patients who had undergone first coronary ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200412000-00006
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000094
更新日期:2014-08-01 00:00:00
abstract::Chronic total occlusions (CTOs) are routinely encountered during coronary angiography, but subsequent revascularization rates are low. This has likely been driven by a historical belief that there is minimal clinical benefit and poor success rates with a percutaneous coronary intervention (PCI). However, in the curren...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0000000000000490
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Recent studies have reported a strong independent association between increased red cell distribution width (RDW) and the risk of adverse outcomes in patients with heart failure, stable coronary disease, and acute coronary syndromes. However, in this study we aimed to determine the impact of an elevated RDW ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283587897
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:The primary end points of randomized clinical trials evaluating the outcome of therapeutic strategies for coronary artery disease (CAD) have included nonfatal acute myocardial infarction, the need for further revascularization, and overall mortality. Noncardiac causes of death may distort the interpretatio...
journal_title:Coronary artery disease
pub_type: 杂志文章,随机对照试验
doi:10.1097/MCA.0b013e32834f112a
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Atrial fibrillation is one of the most common arrhythmias associated with not only increased morbidity after coronary artery bypass grafting but also increased healthcare costs. Many factors are associated with atrial fibrillation onset after coronary artery bypass grafting. We prospectively examined which fa...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3281689a2c
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:We aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction. METHODS:Patients admitted to our emergency department with ST-elevation myocardial infarction ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32835d7633
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Plasma nuclear and mitochondrial DNA (mtDNA) levels are altered in many diseases. However, it is not known whether they are also altered in acute myocardial infarction (AMI). In the present study, we examined plasma nuclear and mtDNA levels in the patients with AMI before and after a percutaneous coronary int...
journal_title:Coronary artery disease
pub_type: 社论
doi:10.1097/MCA.0000000000000231
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Congenital coronary artery fistula (CAF) is a very rare cardiovascular anomaly and only 400 cases have been reported. The purpose of this study was to analyse the experience of surgical treatments in CAF and evaluate the surgical indications, techniques and long-term results. METHODS:A retrospective study r...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199412000-00006
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the safety and efficacy of the novel NovaCross microcatheter system in patients with ischemic heart disease due to coronary chronic total occlusions (CTO). METHODS:A total of 191 subjects between the ages of 25-80 years were recruited in 10 investigational sites. Each s...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000947
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The degree of coronary collateral development is not same in every patient with similar degree of coronary stenosis. In animal studies monocyte chemoattractant protein-1 (MCP-1) has been found to be related to collateral vessel development. In this study we investigated whether a higher serum MCP-1 level is ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32833fd29b
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Although smoking is a risk factor for coronary atherosclerosis, the age-related impact on lesion characteristics and plaque instability remains unclear. PATIENTS AND METHODS:In ADAPT-DES, 780 patients with 916 culprit lesions were evaluated by preprocedural grayscale and virtual histology-intravascular ultr...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000268
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:Vessel bifurcations are prone to atherosclerotic plaque accumulation. Using volumetric intravascular ultrasound analysis, we investigated atheroma distribution at human coronary bifurcations in vivo. METHODS:We analyzed plaque distribution in 49 left anterior descending coronary artery-diagonal and 20 left c...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/01.mca.0000076511.29238.f1
更新日期:2003-06-01 00:00:00
abstract:AIM:This study aimed to investigate whether patients with very low left ventricular ejection fractions (LVEF) should be accepted for reoperative coronary artery bypass grafting (CABG). STUDY POPULATION:Between January 1990 and December 1993, 1681 patients underwent primary CABG and 308 (15.5%) reoperative CABG. One hu...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199505000-00010
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. AIM:To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutane...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000703
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000791
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832ac5eb
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00001
更新日期:1997-03-01 00:00:00