Matrix metalloproteinases and inflammatory markers in coronary artery ectasia: their relationship to severity of coronary artery ectasia.


OBJECTIVE:Although underlying mechanisms of coronary artery ectasia (CAE) are clearly unknown, destruction of extracellular matrix may be responsible for the ectasia formation. Thus, we investigated the role of matrix metalloproteinases (MMP), tissue inhibitor of matrix metalloproteinases (TIMP-1), and inflammatory markers [high-sensitive C-reactive protein, interleukins (ILs)] in CAE patients. METHODS:This study consisted of 28 consecutive CAE patients, 27 obstructive coronary artery disease (CAD) patients, and 22 controls with normal coronary arteries undergoing cardiac catheterization. Plasma levels of MMP-3, MMP-9, TIMP-1, and inflammatory markers were measured. RESULTS:Plasma level of MMP-3 was significantly higher in CAE patients compared with both CAD patients and controls (17.2+/-6.1, 11.2+/-3.2, and 9.2+/-3.4 ng/ml, respectively, both P=0.001) and so did MMP-9 level (27.4+/-5.9, 24.8+/-4.4, and 20.6+/-4.6 ng/ml, respectively, both P<0.05). IL-6 level was also higher in CAE patients than in controls (60.9+/-22.1 vs. 36.1+/-21.5 pg/ml, P=0.001) but were comparable in CAE and CAD patients. Plasma high-sensitive C-reactive protein, IL-1, and TIMP-1 levels were similar in three groups. MMP-3 levels correlated with diffuse (r=0.46, P=0.01) and multivessel ectasia (r=0.45, P=0.02). CONCLUSION:Our results suggest that the increased level of MMP-3, MMP-9, and IL-6 may be responsible for ectasia formation in patients with CAE.


Coron Artery Dis


Coronary artery disease


Dogan A,Tuzun N,Turker Y,Akcay S,Kaya S,Ozaydin M




Has Abstract


2008-12-01 00:00:00














  • Modalities to assess myocardial viability in the modern cardiology era.

    abstract::Detection of viable myocardium in patients with left ventricular dysfunction has become an increasingly important guide to prognosis and treatment. This article reviews the current status and future potential for the application of modalities to assess myocardial viability. Imaging and other techniques that are review...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Hamdan A,Zafrir N,Sagie A,Kornowski R

    更新日期:2006-09-01 00:00:00

  • Metabolic syndrome negatively impacts early patency of saphenous vein grafts.

    abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yilmaz MB,Guray U,Guray Y,Biyikoglu SF,Tandogan I,Sasmaz H,Korkmaz S

    更新日期:2006-02-01 00:00:00

  • Systolic hypertension in older patients: are calcium channel antagonists safe?

    abstract::The Editor and Associate Editors are pleased that our readership will have the opportunity to benefit from a series of contributions by Dr John Rutherford addressing current issues in pharmacology and therapeutics pertinent to coronary artery disease. We are pleased also that Dr Rutherford will provide authoritative p...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rutherford JD

    更新日期:2000-12-01 00:00:00

  • High-dose diltiazem prevents migration and proliferation of vascular smooth muscle cells in various in-vitro models of human coronary restenosis.

    abstract:BACKGROUND:Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS:SMC were isolated by...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Voisard R,Koschnick S,Baur R,Vogel U,Mattfeldt T,Hemmer W,Hannekum A,Höher M,Hombach V

    更新日期:1997-03-01 00:00:00

  • Suboptimal coronary blood flow after primary percutaneous coronary intervention for acute myocardial infarction: incidence, a simple risk score, and prognosis.

    abstract:BACKGROUND:The aim of the present study is to investigate incidence, predictors, and long-term outcomes of suboptimal coronary flow after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) in a large population. METHODS:A total of 2056 consecutive patients with STEMI (mean ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Uyarel H,Ayhan E,Cicek G,Isik T,Ugur M,Bozbay M,Yildirim E,Ergelen M,Eren M

    更新日期:2012-03-01 00:00:00

  • Statins and myocardial hypertrophy.

    abstract::Cardiac hypertrophy is a physiological adaptive response by the heart to pressure overload. However, after prolonged periods, this initial adaptive response becomes maladaptive, leading to increased mortality and morbidity from heart failure. Recently, 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Nakagami H,Liao JK

    更新日期:2004-08-01 00:00:00

  • Early repolarization in the inferolateral leads predicts the presence of vasospastic angina: a novel predictor in patients with resting angina.

    abstract:BACKGROUND:An association between early repolarization and ventricular fibrillation has recently been reported in patients with vasospastic angina (VSA). However, no studies have clarified whether the presence of early repolarization can predict VSA. METHODS:Participants comprised 286 patients (136 males) with clinica...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ikeda H,Hasegawa K,Uzui H,Fukuoka Y,Shiomi Y,Tama N,Miyazaki S,Ishida K,Tada H

    更新日期:2020-11-13 00:00:00

  • Clinical and angiographical characteristics of acetylcholine- induced spasm: relationship to dose of intracoronary injection of acetylcholine.

    abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sueda S,Kohno H,Fukuda H,Inoue K,Suzuki J,Watanabe K,Ochi T,Uraoka T

    更新日期:2002-06-01 00:00:00

  • Diurnal variation of the P-wave dispersion in chronic ischemic heart diseases.

    abstract:OBJECTIVE:Electrocardiographic indices like maximum P-wave duration (P(max)) and P-wave dispersion (PD) can be used to detect patients with atrial conduction disorders, myocardial ischemia and those at risk for atrial fibrillation. Considering the diurnal variation of ischemia in patients with significant coronary lesi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yíldírím N,Topaloglu S,Bozboga S,Ocal A,Saricam E

    更新日期:2006-12-01 00:00:00

  • Hemodynamic changes determine the efficacy of thrombolysis: results from an in-vitro flow model.

    abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Kornowski R,Mendelevich L,Zaretsky U,Einav S,Laniado S,Keren G

    更新日期:1998-01-01 00:00:00

  • Neutrophil hyper-reactivity after exercise-induced angina pectoris.

    abstract:BACKGROUND:Previous studies have suggested an increased risk of myocardial infarction associated with physical exercise. Activated neutrophils may contribute to the triggering mechanisms. METHODS:Fifteen patients with stable angina pectoris underwent symptom-limited bicycle ergometry. In neutrophils obtained from seri...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ott I,Neumann FJ,Schömig A

    更新日期:1995-07-01 00:00:00

  • Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk.

    abstract:OBJECTIVE:Current and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality. PARTICIPANTS AND METHODS:Cases we...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Watts JR Jr,Sonavane SK,Snell-Bergeon J,Nath H

    更新日期:2015-03-01 00:00:00

  • The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease.

    abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin D

    更新日期:2009-05-01 00:00:00

  • Heart cell implantation after myocardial infarction.

    abstract::In the last 15 years, heart cell implantation to regenerate infarcted myocardium has gone from the bench to clinical trial. Several phase I and II controlled randomized trials showed the feasibility, the side effects and the potential efficacy of cell implantation after myocardial infarction in humans. Preclinical exp...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sam J,Angoulvant D,Fazel S,Weisel RD,Li RK

    更新日期:2005-03-01 00:00:00

  • Invasive assessment of microvascular function in patients with valvular heart disease.

    abstract:BACKGROUND:The aim of this study was to investigate microvascular function in patients with valvular heart disease (VHD), which causes chronic left ventricular volume and/or pressure overload, therefore change in coronary microvascular hemodynamics. PATIENTS AND METHODS:We prospectively enrolled 30 patients with VHD c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nishi T,Kitahara H,Saito Y,Nishi T,Nakayama T,Fujimoto Y,Matsumiya G,Kobayashi Y

    更新日期:2018-05-01 00:00:00

  • Can we use plasma hyperosmolality as a predictor of mortality for ST-segment elevation myocardial infarction?

    abstract:BACKGROUND:The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS:This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Tatlisu MA,Kaya A,Keskin M,Uzman O,Borklu EB,Cinier G,Hayiroglu MI,Tatlisu K,Eren M

    更新日期:2017-01-01 00:00:00

  • Cancer-related deaths among different treatment options in chronic coronary artery disease: results of a 6-year follow-up of the MASS II study.

    abstract:INTRODUCTION:The primary end points of randomized clinical trials evaluating the outcome of therapeutic strategies for coronary artery disease (CAD) have included nonfatal acute myocardial infarction, the need for further revascularization, and overall mortality. Noncardiac causes of death may distort the interpretatio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验


    authors: Vieira RD,Pereira AC,Lima EG,Garzillo CL,Rezende PC,Favarato D,Hueb AC,Gersh BJ,Ramires JA,Hueb W

    更新日期:2012-03-01 00:00:00

  • The relation between ABO blood types and clinical and platelet function parameters in patients who underwent percutaneous coronary intervention.

    abstract:BACKGROUND:ABO blood groups have been associated with venous thromboembolism and arterial thrombosis. Although platelets play key roles in thrombogenesis, the relation between ABO groups and platelets is not well known and was investigated in this study. PATIENTS AND METHODS:ABO blood type information was retrospectiv...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Timur AA,Barnard J,Murugesan G,Gandhi S,Bhatt DL,Kottke-Marchant K

    更新日期:2019-01-01 00:00:00

  • Drug-eluting balloons in the treatment of de-novo coronary lesions: a meta-analysis of randomized-controlled trials.

    abstract:AIM:The aim of this meta-analysis was to evaluate the efficacy of drug-eluting balloons (DEBs) plus bare-metal stents (BMS) for the treatment of de-novo coronary lesions. METHODS AND RESULTS:Eleven trials involving 1279 patients were included in this study. The main endpoints were as follows: late lumen loss (LLL), bi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Li Y,Wang C,Zuo G,Wang K,Cao Z,Du X

    更新日期:2016-09-01 00:00:00

  • Cardiac rotation and relaxation after anterolateral myocardial infarction.

    abstract:BACKGROUND:Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. OBJECTIVE:To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterola...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nagel E,Stuber M,Lakatos M,Scheidegger MB,Boesiger P,Hess OM

    更新日期:2000-05-01 00:00:00

  • Platelet-derived growth factor is released into the coronary circulation after coronary spasm.

    abstract:BACKGROUND:Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells and is implicated in the vascular response to injury and the pathogenesis of atherosclerosis. It is also a potent vasoconstrictor. METHODS:To examine whether acute myocardial ischemia increases the level of PDGF in th...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ogawa H,Yasue H,Okumura K,Fujii H,Masuda T,Miyao Y,Bannai S,Takanashi N

    更新日期:1993-05-01 00:00:00

  • Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction.

    abstract:BACKGROUND:Free-radical generation after successful thrombolysis in acute myocardial infarction may jeopardize ischaemic but viable myocardium, thus limiting the optimal benefits of reperfusion. METHODS:Circulating free-radical activity was assessed in 25 consecutive patients with acute myocardial infarction. Those wh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Grech ED,Jack CI,Bleasdale C,Jackson MJ,Baines M,Faragher EB,Hind CR,Perry RA

    更新日期:1993-09-01 00:00:00

  • Comparative effectiveness of different contemporary drug-eluting stents in routine clinical practice: a multigroup propensity score analysis using data from the stent-specific, multicenter, prospective registries.

    abstract:OBJECTIVE:Data on the comparative effectiveness of contemporary drug-eluting stents (DES) in the unrestricted, real-world setting are limited. We investigated the long-term effectiveness and safety of contemporary different drug-eluting stents by means of multiple treatment propensity score weighting. PATIENTS AND MET...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Kwon O,Kang SH,Lee JB,Ahn JM,Lee CH,Kang DY,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park DW,Park SJ,IRIS-DES Registry Investigators.

    更新日期:2019-06-01 00:00:00

  • Role of activation-dependent platelet membrane glycoproteins in development of subacute occlusive coronary stent thrombosis.

    abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gawaz M,Neumann FJ,Ott I,May A,Rüdiger S,Schömig A

    更新日期:1997-03-01 00:00:00

  • Angiogenesis imaging in myocardial infarction using 68Ga-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats.

    abstract:OBJECTIVE:Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS:Ga-NOTA-RGD PET was perform...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Eo JS,Paeng JC,Lee S,Lee YS,Jeong JM,Kang KW,Chung JK,Lee DS

    更新日期:2013-06-01 00:00:00

  • Age-related effects of smoking on culprit lesion plaque vulnerability as assessed by grayscale and virtual histology-intravascular ultrasound.

    abstract:BACKGROUND:Although smoking is a risk factor for coronary atherosclerosis, the age-related impact on lesion characteristics and plaque instability remains unclear. PATIENTS AND METHODS:In ADAPT-DES, 780 patients with 916 culprit lesions were evaluated by preprocedural grayscale and virtual histology-intravascular ultr...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Kang SJ,Mintz GS,Witzenbichler B,Metzger DC,Rinaldi MJ,Duffy PL,Weisz G,Stuckey TD,Brodie BR,Shimizu T,Litherland C,Kirtane AJ,Stone GW,Maehara A

    更新日期:2015-09-01 00:00:00

  • Safety and efficacy of the NovaCross microcatheter in facilitating crossing of chronic total occlusion coronary lesions: a multicenter, single-arm clinical trial.

    abstract:BACKGROUND:The aim of this study was to evaluate the safety and efficacy of the novel NovaCross microcatheter system in patients with ischemic heart disease due to coronary chronic total occlusions (CTO). METHODS:A total of 191 subjects between the ages of 25-80 years were recruited in 10 investigational sites. Each s...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Walsh SJ,Dudek D,Bryniarski L,Nicholson W,Karmpaliotis D,Uretsky B,McEntegart M,Assali A,Knaapen P,Kornowski R,Spratt JC,Goodwin M,Hanratty CG

    更新日期:2020-11-01 00:00:00

  • Postprandial hypertriglyceridemia associated with inflammatory response and procoagulant state after a high-fat meal in hypertensive patients.

    abstract:OBJECTIVE:To investigate the changes of inflammatory factors and hemostatic variable in plasma after a high-fat meal in normocholesterolemic patients with essential hypertension. METHODS:A total of 60 hypertensive patients were randomly assigned to accept a single high-fat meal (group 1, n=40) or not (group 2, n=20) i...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Liu L,Zhao SP,Wen T,Zhou HN,Hu M,Li JX

    更新日期:2008-05-01 00:00:00

  • Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis.

    abstract:BACKGROUND:The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis. METHODS:Seve...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hasan-Ali H,Abd El-Mottaleb NA,Hamed HB,Abd-Elsayed A

    更新日期:2011-06-01 00:00:00

  • Multidetector computed tomography guidance in complex cardiac ablations.

    abstract::Radiofrequency ablation of complex cardiac arrhythmias has undergone significant evolution in the past decade, with the development of technology enabling better anatomic and electrophysiologic mapping of abnormal cardiac tissue. In this paper, we will discuss the role of pre-procedural and post-procedural multidetect...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Lobel RM,Lustgarten DL,Spector PS

    更新日期:2006-03-01 00:00:00