Abstract:
:The effects of moclobemide, 450 mg/day, on sleep were investigated in 12 patients with major depression. The study was carried out over six weeks, divided into three periods: (1) treatment for one week with placebo and measurement to obtain baseline values; (2) treatment with moclobemide for four weeks; and (3) one week withdrawal period. Polygraphic sleep recording, all-night sleep-EEG spectral analysis, and diurnal EEG vigilance mapping were used to determine the effects of this antidepressant. An activating effect was observed, most marked during the early phase of treatment. The most noticeable effects were on REM sleep, affecting polysomnographic and spectral sleep EEG parameters. A REM sleep habituation phenomenon was observed, and a slight REM sleep rebound effect occurred early during withdrawal. The observed neuroelectrophysiological changes appear to be specific for moclobemide and differ from those brought about by other antidepressants.
journal_name
Int Clin Psychopharmacoljournal_title
International clinical psychopharmacologyauthors
Minot R,Luthringer R,Macher JPdoi
10.1097/00004850-199300730-00009subject
Has Abstractpub_date
1993-01-01 00:00:00pages
181-9issue
3-4eissn
0268-1315issn
1473-5857journal_volume
7pub_type
临床试验,杂志文章abstract::The primary objective of this post-hoc analysis was to evaluate the effect of short-term treatment with desvenlafaxine versus placebo on sexual dysfunction (SD), assessed from Arizona Sexual Experiences Scale scores, in adult outpatients with major depressive disorder. Data from three randomized, double-blind, placebo...
journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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