Abstract:
:The interaction between plasma concentrations of the tricyclic antidepressant amitriptyline and the metabolism of the new antipsychotic risperidone was studied in 12 patients with chronic schizophrenia. Each patient received 3 mg risperidone twice a day for 28 days. Amitriptyline was coadministered at doses of 50 mg/day on day 15 and 100 mg/day on days 16 to 21. Amitriptyline did not significantly affect the mean plasma concentrations or pharmacokinetics of risperidone in schizophrenic patients or influence the antipsychotic fraction (the total concentration of risperidone and 9-hydroxyrisperidone, its primary and biologically active metabolite). These results suggest that risperidone dose need not be adjusted when coadministered with amitriptyline at doses up to 100 mg/day in schizophrenic patients.
journal_name
Int Clin Psychopharmacoljournal_title
International clinical psychopharmacologyauthors
Sommers DK,Snyman JR,van Wyk M,Blom MW,Huang ML,Levron JCdoi
10.1097/00004850-199705000-00004subject
Has Abstractpub_date
1997-05-01 00:00:00pages
141-5issue
3eissn
0268-1315issn
1473-5857journal_volume
12pub_type
临床试验,杂志文章abstract::The objective of this study was to assess the response of anxiety and depression symptoms to methylphenidate (MPH) treatment in patients with Asperger syndrome (AS) combined with attention deficit/hyperactivity disorder (ADHD). A group of 12 patients with AS/ADHD, aged 8-18 years, received 12 weeks of MPH treatment. T...
journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004850-199300830-00001
更新日期:1993-10-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-09-01 00:00:00
abstract::Clozapine is the only evidence-based antipsychotic for treatment-resistant schizophrenia. However, it has considerable side effects, limiting its usability and reducing patients' adherence. One of the most common and distressing side effects is hypersalivation, which can be debilitating, stigmatizing and potentially d...
journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2019-03-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1097/00004850-198807000-00001
更新日期:1988-07-01 00:00:00
abstract::Since the introduction in 1993 of the novel serotonin-dopamine antagonist antipsychotic risperidone, over 12 million patient-months of exposure to the drug have been accumulated. Further studies have confirmed the efficacy of risperidone across a broad range of patients with schizophrenia who were not represented in t...
journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章
doi:10.1097/00004850-199809000-00008
更新日期:1998-09-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章
doi:10.1097/00004850-199612000-00005
更新日期:1996-12-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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