Abstract:
:Sixteen young male volunteers received single doses of moclobemide 200 mg, moclobemide 400 mg, amitriptyline 50 mg and placebo in a double-blind crossover study. Subjects then completed a test battery which is sensitive to the effects of psychoactive drugs at 1, 2, and 4 h post-dose. The test battery included tasks of choice reaction time, tracking, critical flicker fusion threshold and memory scanning. Subjective feelings were assessed using the Leeds sleep evaluation questionnaire (LSEQ) and line analogue rating scales (LARS). The results show that the positive internal control (amitriptyline) has a sedative effect in that it increased critical flicker fusion threshold, reaction time and tracking error. Moclobemide 400 mg increased reaction time in the tracking task but neither dose of moclobemide impaired psychomotor performance or cognitive ability in any of the other tests.
journal_name
Int Clin Psychopharmacoljournal_title
International clinical psychopharmacologyauthors
Fairweather DB,Kerr JS,Hindmarch Idoi
10.1097/00004850-199300810-00007subject
Has Abstractpub_date
1993-04-01 00:00:00pages
43-7issue
1eissn
0268-1315issn
1473-5857journal_volume
8pub_type
临床试验,杂志文章,随机对照试验abstract::In this paper we review the history of antidepressant (AD) development, since the discovery of imipramine in 1957 to the present day. Through this exploration we will show that the increasing placebo response is likely a red herring and that a higher magnitude of placebo response is not an adequate explanation for AD ...
journal_title:International clinical psychopharmacology
pub_type: 历史文章,杂志文章,评审
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abstract::The objective of this study was to assess the response of anxiety and depression symptoms to methylphenidate (MPH) treatment in patients with Asperger syndrome (AS) combined with attention deficit/hyperactivity disorder (ADHD). A group of 12 patients with AS/ADHD, aged 8-18 years, received 12 weeks of MPH treatment. T...
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pub_type: 临床试验,杂志文章
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abstract::Post-traumatic stress disorder (PTSD) is frequently treated with antidepressant medications, especially the newer selective serotonergic antidepressants which have documented efficacy in PTSD. Analogous to depression, however, some PTSD patients may not have a satisfactory response to these agents. This case report de...
journal_title:International clinical psychopharmacology
pub_type: 杂志文章
doi:10.1097/00004850-199809000-00008
更新日期:1998-09-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00004850-200303000-00005
更新日期:2003-03-01 00:00:00
abstract::Platelet serotonin type 2A receptor (5-HT2A) sensitivity changes have previously been documented in depression, although it is unclear if this represents a stable trait marker of the illness, or whether it represents an acute state marker of depression that would change with treatment. Electroconvulsive therapy (ECT) ...
journal_title:International clinical psychopharmacology
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doi:10.1097/00004850-200015020-00005
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abstract::Social dysfunction is often associated with depressive disorders and its evaluation is an important measure of treatment outcome. The aim of this study was to assess the effect of two treatments, venlafaxine and amitriptyline, on the social functioning of depressed patients. Twenty-eight outpatients, meeting criteria ...
journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00004850-200207000-00003
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-01-01 00:00:00
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,评审
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章,评审
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journal_title:International clinical psychopharmacology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
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journal_title:International clinical psychopharmacology
pub_type: 杂志文章
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