Risperidone-induced retrograde ejaculation: case report and review of the literature.

Abstract:

:Medication adherence with antipsychotics is adversely impacted by the burden of untoward adverse effects. In particular, sexual side-effects may interfere with compliance, but are often underreported by patients. Sexual dysfunction related to hyperprolactinemia is commonly described, but ejaculatory disturbance due to potent alpha1 adrenergic antagonism may also occur, and has been reported frequently with certain typical antipsychotics such as thioridazine, but rarely with atypical antipsychotics. Presented here is the case of a 51 year old male with schizophrenia who developed retrograde ejaculation on high dose risperidone therapy (8 mg/day) with prompt resolution of symptoms upon dose reduction. The absence of decreased libido or erectile dysfunction indicates that alpha1 adrenergic antagonism and not low serum testosterone due to hyperprolactinemia is the etiology for this side-effect. This case illustrates another mechanism for sexual adverse effects, and the need for routine inquiry into sexual dysfunction during atypical antipsychotic therapy.

authors

Loh C,Leckband SG,Meyer JM,Turner E

doi

10.1097/00004850-200403000-00009

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

111-2

issue

2

eissn

0268-1315

issn

1473-5857

pii

00004850-200403000-00009

journal_volume

19

pub_type

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