Clinical utility of milnacipran in comparison with other antidepressants.

Abstract:

:The utility of milnacipran in the treatment of major depression has been the subject of an extensive clinical development programme. Comparative studies with tricyclic antidepressant drugs have demonstrated equivalent efficacy, with improved tolerability, in particular with respect to autonomic effects. In comparison with selective serotonin reuptake inhibitors (SSRIs), milnacipran shows similar good tolerability. It appears superior to such drugs in the treatment of severe depression, but equivalent to them for mild to moderate depression. In contrast to treatment with SSRIs, treatment response to milnacipran appears to be associated with the degree of psychomotor retardation. The good tolerability of milnacipran makes it safe in overdose. This drug also has a beneficial effect on suicidal ideation. Maintenance therapy with milnacipran has been demonstrated to reduce the recurrence of depressive episodes.

authors

Bisserbe JC

doi

10.1097/00004850-200206001-00006

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

S43-50

eissn

0268-1315

issn

1473-5857

journal_volume

17 Suppl 1

pub_type

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