Addressing parents' concerns: do vaccines cause allergic or autoimmune diseases?

Abstract:

:Anecdotal case reports and uncontrolled observational studies in the medical literature claim that vaccines cause chronic diseases such as asthma, multiple sclerosis, chronic arthritis, and diabetes. Several biological mechanisms have been proposed to explain how vaccines might cause allergic or autoimmune diseases. For example, allergic diseases might be caused by prevention of early childhood infections (the "hygiene hypothesis"), causing a prolongation of immunoglobulin E-promoting T-helper cell type 2-type responses. However, vaccines do not prevent most common childhood infections, and large well-controlled epidemiologic studies do not support the hypothesis that vaccines cause allergies. Autoimmune diseases might occur after immunization because proteins on microbial pathogens are similar to human proteins ("molecular mimicry") and could induce immune responses that damage human cells. However, wild-type viruses and bacteria are much better adapted to growth in humans than vaccines and much more likely to stimulate potentially damaging self-reactive lymphocytes. Consistent with critical differences between natural infection and immunization, well-controlled epidemiologic studies do not support the hypothesis that vaccines cause autoimmunity. Flaws in proposed biological mechanisms that explain how vaccines might cause chronic diseases are consistent with the findings of many well-controlled large epidemiologic studies that fail to show a causal relationship.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Offit PA,Hackett CJ

doi

10.1542/peds.111.3.653

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

653-9

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

111

pub_type

杂志文章,评审
  • Delivery room decision-making for extremely preterm infants in Sweden.

    abstract:OBJECTIVE:To assess neonatologists' attitudes and practices regarding treatment of extremely preterm infants in the delivery room, particularly in response to parental wishes. STUDY DESIGN:Cross-sectional survey of all neonatologists in Sweden registered with the Swedish Pediatric Society. RESULTS:The response rate w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1885

    authors: Peerzada JM,Schollin J,Håkansson S

    更新日期:2006-06-01 00:00:00

  • Regulation of growth of 7- to 36-month-old children by energy and fat intake in the prospective, randomized STRIP baby trial.

    abstract:OBJECTIVE:To study the fat and energy intakes of children between 7 and 36 months of age with different growth patterns. METHODS:In the Special Turku coronary Risk factor Intervention Project for Babies, children were randomized to intervention (n = 540) and control groups (n = 522) at age 7 months. The intervention w...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.100.5.810

    authors: Niinikoski H,Viikari J,Rönnemaa T,Helenius H,Jokinen E,Lapinleimu H,Routi T,Lagström H,Seppänen R,Välimäki I,Simell O

    更新日期:1997-11-01 00:00:00

  • Use of trained mothers to teach interviewing skills to first-year medical students: a follow-up study.

    abstract::This report describes an attempt to evaluate the effectiveness of "trained mother" interviews early in the medical school curriculum. As an adjunct to a first-year course that teaches interviewing techniques, half of the students were exposed to an interview with one of three trained mothers early in the course. This ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stillman PL,Sabers DL,Redfield DL

    更新日期:1977-08-01 00:00:00

  • Technical report: coparent or second-parent adoption by same-sex parents.

    abstract::A growing body of scientific literature demonstrates that children who grow up with 1 or 2 gay and/or lesbian parents fare as well in emotional, cognitive, social, and sexual functioning as do children whose parents are heterosexual. Children's optimal development seems to be influenced more by the nature of the relat...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.109.2.341

    authors: Perrin EC,Committee on Psychosocial Aspects of Child and Family Health.

    更新日期:2002-02-01 00:00:00

  • Considering complementary and alternative medicine alternatives in cases of life-threatening illness: applying the best-interests test.

    abstract::In this article we explore decision-making about treatment when a child faces a life-threatening illness but conventional treatment presents substantial risk and uncertain benefit. When is it acceptable for parents to decide to use complementary and alternative medicine as an alternative, rather than a complement, to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2720F

    authors: Gilmour J,Harrison C,Asadi L,Cohen MH,Aung S,Vohra S

    更新日期:2011-11-01 00:00:00

  • Voiding after neonatal circumcision.

    abstract:OBJECTIVE:To determine whether it is necessary to delay discharge of newly circumcised male neonates to observe voiding. SUBJECTS AND METHODS:A prospective study was conducted in 1992 and 1993 of 51 healthy male, newly circumcised neonates between 0 and 10 days of age. The neonates were observed for the time of first ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Perlmutter DF,Lawrence JM,Krauss AN,Auld PA

    更新日期:1995-12-01 00:00:00

  • Language problems in children with ADHD: a community-based study.

    abstract:OBJECTIVES:To examine the prevalence of language problems in children with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls, and the impact of language problems on the social and academic functioning of children with ADHD. METHODS:Children (6 to 8 years) with ADHD (n = 179) and controls (n = 21...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3355

    authors: Sciberras E,Mueller KL,Efron D,Bisset M,Anderson V,Schilpzand EJ,Jongeling B,Nicholson JM

    更新日期:2014-05-01 00:00:00

  • Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions.

    abstract::To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study. The patients and the treatments were ran...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Chow OK,Fung KP

    更新日期:1989-07-01 00:00:00

  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

    abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lorentz WB Jr,Resnick MI

    更新日期:1979-11-01 00:00:00

  • Socioeconomic, family, and pediatric practice factors that affect level of asthma control.

    abstract:BACKGROUND:Multiple issues play a role in the effective control of childhood asthma. OBJECTIVE:To identify factors related to the level of asthma control in children receiving asthma care from community pediatricians. PATIENTS AND METHODS:Data for 362 children participating in an intervention study to reduce asthma m...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0504

    authors: Bloomberg GR,Banister C,Sterkel R,Epstein J,Bruns J,Swerczek L,Wells S,Yan Y,Garbutt JM

    更新日期:2009-03-01 00:00:00

  • Iron-fortified formulas and gastrointestinal symptoms in infants: a controlled study, With the cooperation of The Syracuse Consortium for Pediatric Clinical Studies.

    abstract::In an attempt to determine whether iron-fortified infant formulas produced gastrointestinal symptoms in infants, we fed two similar formulas, one with and one without iron fortification, to a group of 93 term infants upon discharge from the nursery on the third day of life. Infants were fed the formulas for a period o...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1980-08-01 00:00:00

  • Familial nonobstructive cardiomyopathy with endocardial fibroelastosis beyond infancy.

    abstract::A 10-year-old boy with congestive heart failure died in five months in spite of comprehensive medical treatment. Autopsy showed patchy areas of endocardial fibroelastosis of the left ventricle. The sister of this patient had followed a similar course at 13 years of age with death within six months of the onset of cong...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.410

    authors: Singh A,Doyle EF,Danilowicz DA,Finegold MJ

    更新日期:1978-03-01 00:00:00

  • Principles of Child Health Care Financing.

    abstract::After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7%...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2098

    authors: Hudak ML,Helm ME,White PH,COMMITTEE ON CHILD HEALTH FINANCING.

    更新日期:2017-09-01 00:00:00

  • Controlled evaluation of muscle relaxation in the ventilated neonate.

    abstract::To assess the effects of muscle relaxation on the critically ill ventilated neonate, pancuronium bromide was administered for a 12-hour period to ten low-birth-weight neonates (960 to 2,000 gm) of 26 to 34 weeks gestation, all whom required mechanical ventilation and were studied within 48 hours of birth (six to 39 ho...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Finer NN,Tomney PM

    更新日期:1981-05-01 00:00:00

  • A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns.

    abstract:OBJECTIVES:Severe neonatal jaundice is a common clinical manifestation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and the most difficult to manage; kernicterus is not an uncommon outcome. We assessed in healthy, direct Coombs test-negative Greek newborns of >/=38 weeks' gestational age 1) the current burd...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.25

    authors: Kappas A,Drummond GS,Valaes T

    更新日期:2001-07-01 00:00:00

  • Interpreters: telephonic, in-person interpretation and bilingual providers.

    abstract:CONTEXT:Language barriers affect health care interactions. Large, randomized studies of the relative efficacy of interpreter modalities have not been conducted. OBJECTIVE:To compare the efficacy of telephonic and in-person medical interpretation to visits with verified bilingual physicians. METHODS:This was a prospec...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-0769

    authors: Crossman KL,Wiener E,Roosevelt G,Bajaj L,Hampers LC

    更新日期:2010-03-01 00:00:00

  • Ensuring Timely Connection to Early Intervention for Young Children With Developmental Delays.

    abstract:BACKGROUND AND OBJECTIVES:Timely provision of developmental services can improve outcomes for children 0 to 3 years old with developmental delays. Early Intervention (EI) provides free developmental services to children under age 3 years; however, data suggests that many children referred to EI never connect to the pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4017

    authors: Conroy K,Rea C,Kovacikova GI,Sprecher E,Reisinger E,Durant H,Starmer A,Cox J,Toomey SL

    更新日期:2018-07-01 00:00:00

  • Quality health care for children and the Affordable Care Act: a voltage drop checklist.

    abstract::The Affordable Care Act (ACA) introduces enormous policy changes to the health care system with several anticipated benefits and a growing number of unanticipated challenges for child and adolescent health. Because the ACA gives each state and their payers substantial autonomy and discretion on implementation, underst...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-0881

    authors: Cheng TL,Wise PH,Halfon N

    更新日期:2014-10-01 00:00:00

  • The clinical, biochemical, and familial presentation of type V hyperlipoproteinemia in childhood.

    abstract::Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kwiterovich PO Jr,Farah JR,Brown WV,Bachorik PS,Baylin SB,Neill CA

    更新日期:1977-04-01 00:00:00

  • Enuresis: a contrast of attitudes of parents and physicians.

    abstract::Questionnaires were used to survey 1,435 parents and 446 physicians in order to determine and compare attitudes and beliefs about enuresis. Although both groups thought that bed-wetting is a maturational problem, the parent group thought emotional causes were important and were less likely to accept small bladder size...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Shelov SP,Gundy J,Weiss JC,McIntire MS,Olness K,Staub HP,Jones DJ,Haque M,Ellerstein NS,Heagarty MC,Starfield B

    更新日期:1981-05-01 00:00:00

  • Trends in Weight-for-Length Among Infants in WIC From 2000 to 2014.

    abstract:OBJECTIVES:To describe the prevalence and secular trends of high weight-for-length among infants (ages, 3-23 months) in the biennial US Department of Agriculture Women, Infants, and Children Program and Participants Characteristic (WIC-PC) Survey from 2000 through 2014 (n = 16 927 120). METHODS:Weight-for-length was c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2034

    authors: Freedman DS,Sharma AJ,Hamner HC,Pan L,Panzera A,Smith RB,Blanck HM

    更新日期:2017-01-01 00:00:00

  • Total population estimate of newborn special-care bed needs.

    abstract::In 1977, 7% of the 38,855 infants born in Utah were estimated to have required a total of 27,439 special-care hospital days. About half (53%) were mildly ill; their average length of stay was 4.6 days, or 24% of the total hospital-days. Another 20% of the infants had intermediate illness, with a 12-day average stay, o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jung AL,Streeter NS

    更新日期:1985-06-01 00:00:00

  • Interventions to improve cortisol regulation in children: a systematic review.

    abstract::Childhood adversity is associated with physiologic dysregulation across multiple biological systems; however, relatively little is known about whether these changes are reversible with intervention. The objective of this review was to examine evidence for the effectiveness of interventions to promote healthy cortisol ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-1632

    authors: Slopen N,McLaughlin KA,Shonkoff JP

    更新日期:2014-02-01 00:00:00

  • Rapid fluorometric assay of bilirubin and bilirubin binding capacity in blood of jaundiced neonates: comparisons with other methods.

    abstract::The concentrations of total blood bilirubin, albumin-bound bilirubin, and the reserve and total bilirubin binding capacities of 35 neonatal blood samples (28 patients) were determined by automated front-face fluorometry ((hematofluorometer). These values were compared to results of diazo determinations, Sephadex gel f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cashore WJ,Oh W,Blumberg WE,Eisinger J,Lamola AA

    更新日期:1980-09-01 00:00:00

  • An environmental intervention to reduce dietary fat in school lunches.

    abstract:OBJECTIVE:To determine whether making a low-fat entree available as one of two choices in an elementary school lunch program would reduce the fat content of meals selected by children. DESIGN:In this before-after trial, students had a daily choice between two entrees, one of which was sometimes low-fat. For 93% of sch...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Whitaker RC,Wright JA,Finch AJ,Psaty BM

    更新日期:1993-06-01 00:00:00

  • Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports.

    abstract::Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intensive...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.1012

    authors: Das UG,Sasidharan P

    更新日期:2001-10-01 00:00:00

  • Etiology of childhood bacteremia and timely antibiotics administration in the emergency department.

    abstract:BACKGROUND:Bacteremia is now an uncommon presentation to the children's emergency department (ED) but is associated with significant morbidity and mortality. Its evolving etiology may affect the ability of clinicians to initiate timely, appropriate antimicrobial therapy. METHODS:A retrospective time series analysis of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2061

    authors: Irwin AD,Drew RJ,Marshall P,Nguyen K,Hoyle E,Macfarlane KA,Wong HF,Mekonnen E,Hicks M,Steele T,Gerrard C,Hardiman F,McNamara PS,Diggle PJ,Carrol ED

    更新日期:2015-04-01 00:00:00

  • Creation and development of the public service orphan drug Human Botulism Immune Globulin.

    abstract::The public service orphan drug Human Botulism Immune Globulin for the treatment of infant botulism would not have come into existence without the federal Orphan Drug Act and the funding mechanism that it provided to conduct pivotal clinical trials. Nonetheless, creating, developing, and achieving licensure of Human Bo...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2006-0646

    authors: Arnon SS

    更新日期:2007-04-01 00:00:00

  • Successful Chest Radiograph Reduction by Using Quality Improvement Methodology for Children With Asthma.

    abstract:OBJECTIVES:Implementation of an asthma clinical practice guideline did not achieve desired chest radiograph (CXR) usage goals. We attempt to use quality improvement methodology to decrease the percentage of CXRs obtained for pediatric patients with acute asthma exacerbations from 29.3% to <20% and to evaluate whether d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4003

    authors: Watnick CS,Arnold DH,Latuska R,O'Connor M,Johnson DP

    更新日期:2018-08-01 00:00:00

  • Epidemiology of juvenile chronic arthritis in southwestern Sweden: a 5-year prospective population study.

    abstract::Previous epidemiological studies of juvenile chronic arthritis (JCA) report divergent results owing to differences in diagnostic criteria, patient retrieval, and study designs. To investigate incidence and prevalence of JCA in a total population, this prospective survey was performed in southwestern Sweden between 198...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gäre BA,Fasth A

    更新日期:1992-12-01 00:00:00