Efficacy and mode of action of manidipine: a new calcium antagonist.

abstract：:Percutaneous transluminal coronary recanalization, a new therapeutic procedure used in acute myocardial infarction, offers significant reduction in mortality, as well as more effective limitation of the zone of infarction than has been possible with other pharmacologic treatment employed in the past. The risk of coron...

journal_title：American heart journal

authors： Rutsch W,Schartl M,Mathey D,Kuck K,Merx W,Dörr R,Rentrop P,Blanke H

更新日期：1981-12-01 00:00:00

abstract：:In order to correlate the antiarrhythmic and electrophysiological effects of disopyramide phosphate during acute myocardial ischemia, we performed experiments in 17 mongrel dogs. Refractory periods obtained by the extrastimulus method and conduction times recorded from local electrograms were determined in potentially...

journal_title：American heart journal

authors： Levites R,Anderson GJ

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:ISAR-REACT was a trial designed to evaluate whether the glycoprotein IIb/IIIa inhibitor abciximab is beneficial in patients undergoing elective percutaneous coronary intervention (PCI) with stent placement after pretreatment with a 600 mg loading dose of clopidogrel. Objective for the angiographic substudy w...

journal_title：American heart journal

authors： Schühlen H,Kastrati A,Mehilli J,Hausleiter J,Dirschinger J,Dotzer F,Bollwein H,Schömig A

更新日期：2006-06-01 00:00:00

abstract：:Coronary atherosclerosis may cause acute and chronic ischemic syndromes; the former are caused by "acute plaque events," mostly thrombosis complicating vulnerable ruptured plaques, namely severe lesions with large core, thin cap, and weak shoulder infiltrated by activated inflammatory cells. Plaque rupture may also oc...

journal_title：American heart journal

authors： Arbustini E,Morbini P,Bello BD,Prati F,Specchia G

更新日期：1999-08-01 00:00:00

abstract：:Chronic exposure to fine particulate matter (PM2.5) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of th...

journal_title：American heart journal

authors： Loop MS,McClure LA,Levitan EB,Al-Hamdan MZ,Crosson WL,Safford MM

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement. However, although the benefits of this beta-blocker have been established in patients with chronic heart failure, the mechanisms underlying them and the changes in left ventricular systolic fun...

journal_title：American heart journal

authors： Capomolla S,Febo O,Gnemmi M,Riccardi G,Opasich C,Caporotondi A,Mortara A,Pinna GD,Cobelli F

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. METHODS:Plate...

journal_title：American heart journal

authors： Serebruany VL,Cummings CC,Malinin AI,Steinhubl SR,Gurbel PA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:A subset of patients hospitalized with acute heart failure experiences in-hospital worsening heart failure, defined as persistent or worsening signs or symptoms requiring an escalation of therapy. METHODS:We analyzed data from the Acute Decompensated Heart Failure National Registry (ADHERE) linked to Medica...

journal_title：American heart journal

authors： DeVore AD,Greiner MA,Sharma PP,Qualls LG,Schulte PJ,Cooper LB,Mentz RJ,Pang PS,Fonarow GC,Curtis LH,Hernandez AF

更新日期：2016-08-01 00:00:00

abstract：:Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 micrograms/kg/min) was performed in 11 subjects. Subjec...

journal_title：American heart journal

authors： Villegas BJ,Hendel RC,Dahlberg ST,McSherry BA,Leppo JA

更新日期：1993-07-01 00:00:00

abstract：:Two double-blind multicenter studies compared acebutolol with placebo (acebutolol, N = 121; placebo, N = 116) and with propranolol (acebutolol, N = 186; propranolol, N = 190) in essential hypertension. Acebutolol significantly reduced mean sitting diastolic blood pressure from 99.2 +/- 0.3 mm Hg at baseline to 89.1 +/...

journal_title：American heart journal

authors： Davidov M

更新日期：1985-05-01 00:00:00

abstract：:The objective of treating patients with hypertension is not simply to reduce blood pressure but rather to prevent the associated morbidity and mortality. Recent assessments of clinical trials have shown that while the risk of stroke is consistently lower with antihypertensive therapy, the same degree of success has no...

journal_title：American heart journal

authors： Black HR

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:To evaluate the impact of adjunctive high-dose glucose-insulin-potassium (GIK) on ST-segment elevation resolution in patients with ST-segment elevation myocardial infarction (MI). METHODS:As part of a randomized controlled trial of GIK versus no GIK in patients treated with primary percutaneous coronary int...

journal_title：American heart journal

authors： van der Horst IC,De Luca G,Ottervanger JP,de Boer MJ,Hoorntje JC,Suryapranata H,Dambrink JH,Gosselink AT,Zijlstra F,van 't Hof AW

更新日期：2005-06-01 00:00:00

abstract：:This study compares the effectiveness of teaching the calculation of frontal plane QRS axis with the use of the classical versus the orderly electrocardiographic limb lead display. Eighty-three students from two environments were randomized into two groups and were taught to determine frontal plane axis with one of th...

journal_title：American heart journal

authors： Pahlm US,O'Brien JE,Pettersson J,Pahlm O,White T,Maynard C,Wagner GS

更新日期：1997-12-01 00:00:00

abstract：:Terazosin is a new, long-acting, selective, postsynaptic alpha 1-adrenergic receptor antagonist with a chemical structure similar to that of prazosin. In this article the pharmacokinetics of terazosin are reviewed, and the incidence of adverse events in a dose-response study and a meta-analysis of 20 placebo-controlle...

journal_title：American heart journal

authors： Somberg JC,Achari R,Laddu AR

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:It has been shown that transient increase in left ventricular stiffness, assessed by Doppler-derived early filling deceleration time, occurs during the first 24 to 48 hours after myocardial infarction but returns to normal within several days. It has been reported that hyperbaric oxygen treatment has a favor...

journal_title：American heart journal

authors： Vlahović A,Nesković AN,Dekleva M,Putniković B,Popović ZB,Otasević P,Ostojić M

更新日期：2004-07-01 00:00:00

abstract：:Atherosclerotic coronary artery disease is a serious clinical problem. Clinicians dealing with patients can make a diagnosis of coronary disease in several ways. Unfortunately all too often the diagnosis is made via sudden death or acute myocardial infarction. At other times the diagnosis is made by evaluation of pati...

journal_title：American heart journal

authors： Anderson HV,King SB 3rd

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Inflammation has been suggested as a factor in the initiation and maintenance of atrial fibrillation (AF). Several observational studies have suggested that statins, presumably through their anti-inflammatory properties, decrease the risk of AF. METHODS:We analyzed 2 large, randomized trials, PROVE IT-TIMI ...

journal_title：American heart journal

authors： McLean DS,Ravid S,Blazing M,Gersh B,Shui A,Cannon CP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:beta-blockers have been shown to benefit patients after myocardial infarction by decreasing mortality, sudden cardiac death, and reinfarction. Although beta-blockers are recommended for all patients with acute coronary syndromes (ACS) without contraindications, a target heart rate (HR) is recommended only fo...

journal_title：American heart journal

authors： Herman M,Donovan J,Tran M,McKenna B,Gore JM,Goldberg RJ,Tighe DA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Older adults presenting with acute myocardial infarction (MI) often have multivessel coronary artery disease amenable to percutaneous coronary intervention (PCI), yet the risks of multivessel intervention may outweigh potential benefits in these patients. We sought to determine if nonculprit intervention dur...

journal_title：American heart journal

authors： Wang TY,McCoy LA,Bhatt DL,Rao SV,Roe MT,Resnic FS,Cavender MA,Messenger JC,Peterson ED

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:There are limited data regarding the clinical correlates and prognostic significance of echocardiographically defined mitral regurgitation (MR) early after acute myocardial infarction (MI). The current study addressed these issues. METHODS:Seven hundred thirty-seven patients with acute MI who underwent tran...

journal_title：American heart journal

authors： Hillis GS,Møller JE,Pellikka PA,Bell MR,Casaclang-Verzosa GC,Oh JK

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Patients with atrial fibrillation (AF) are at increased risk for ischemic stroke. In patients who have suffered a stroke, screening for AF is routinely performed only for a short period after the stroke as part of the evaluation for possible causes. If AF is detected after an ischemic stroke, oral anticoagul...

journal_title：American heart journal

authors： Sinha AM,Diener HC,Morillo CA,Sanna T,Bernstein RA,Di Lazzaro V,Passman R,Beckers F,Brachmann J

更新日期：2010-07-01 00:00:00

abstract：:The primary objective of this study was to apply a sophisticated coagulation monitoring system including estimation of the concentration of prothrombin fragment 1 + 2 (PTF 1 + 2) and the activity of prothrombin (coagulation factor II or FII) to cases of stent implantation and to compare the results with those of stand...

journal_title：American heart journal

authors： Haude M,Hafner G,Jablonka A,Rupprecht HJ,Prellwitz W,Meyer J,Erbel R

更新日期：1995-08-01 00:00:00

abstract：:To investigate the significance of atrial natriuretic polypeptide (ANP) in essential hypertension, we measured plasma ANP concentrations in 43 subjects with essential hypertension uncomplicated by cardiac or renal failure, in 16 subjects with borderline hypertension, and in 17 normotensive control subjects. Plasma ANP...

journal_title：American heart journal

authors： Kohno M,Yasunari K,Matsuura T,Murakawa K,Takeda T

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Although the management of thoracic aortic aneurysms (TAAs) has improved significantly, patients presenting with aortic dissections, rupture, or other acute complications of TAAs continue to have high rates of morbidity and mortality. Accumulating data have indicated that many TAAs are due to underlying gene...

journal_title：American heart journal

authors： Eagle KA,GenTAC Consortium.

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To assess whether serum uric acid, which is a marker of impaired oxidative metabolism, might correlate with left ventricular systolic and diastolic dysfunction in patients with chronic heart failure (CHF). BACKGROUND:Uric acid levels, which are frequently elevated in patients with CHF, correlate with leg vas...

journal_title：American heart journal

authors： Cicoira M,Zanolla L,Rossi A,Golia G,Franceschini L,Brighetti G,Zeni P,Zardini P

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Optimal antithrombotic treatment after transcatheter aortic valve replacement (TAVR) is unknown and determined empirically. The direct factor Xa inhibitor rivaroxaban may potentially reduce TAVR-related thrombotic complications and premature valve failure. DESIGN:GALILEO is an international, randomized, ope...

journal_title：American heart journal

authors： Windecker S,Tijssen J,Giustino G,Guimarães AH,Mehran R,Valgimigli M,Vranckx P,Welsh RC,Baber U,van Es GA,Wildgoose P,Volkl AA,Zazula A,Thomitzek K,Hemmrich M,Dangas GD

更新日期：2017-02-01 00:00:00

abstract：:Inhibition of the enzyme that synthesizes thromboxanes may protect against the development of ventricular fibrillation (VF) during acute myocardial ischemia. This study was carried out to test this hypothesis with a new thromboxane synthetase inhibitor, and to extend the studies to alternative animal models of myocard...

journal_title：American heart journal

authors： O'Connor KM,Friehling TD,Kowey PR

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Diabetes is associated with a high rate of events after acute coronary syndrome and percutaneous coronary intervention despite aspirin treatment. Once daily aspirin might not provide 24-hour stable biological efficacy in patients with diabetes. We compared the biological efficacy of the same daily dose of as...

journal_title：American heart journal

authors： Dillinger JG,Drissa A,Sideris G,Bal dit Sollier C,Voicu S,Manzo Silberman S,Logeart D,Drouet L,Henry P

更新日期：2012-10-01 00:00:00

abstract：:Baroreflex modulation of forearm vascular resistance (FVR) has been reported to be abnormal in patients with congestive heart failure (CHF). However, the neurohumoral mechanisms for this impairment are not defined. We assessed the responses of arterial pressure, FVR, plasma norepinephrine, and plasma renin activity to...

journal_title：American heart journal

authors： Mohanty PK,Arrowood JA,Ellenbogen KA,Thames MD

更新日期：1989-07-01 00:00:00

abstract：:We performed a chronologic investigation of left (LV) and right (RV) ventricular myosin ATPase activity and hemodynamics in newborn lambs. We found an elevation in myosin ATPase activity for the LV, which was achieved by 6 to 8 weeks of age and which correlated directly with increasing ventricular stroke work. Myosin ...

journal_title：American heart journal

authors： Riemenschneider TA,Brenner RA,Wikman-Coffelt J,Mason DT

更新日期：1982-05-01 00:00:00