Abstract：
:White blood cell (WBC) phagocytosis was investigated as a potential immunological indicator of methylmercury (MeHg) exposure in birds. The assay was first assessed using chicken WBCs dosed with MeHg in vitro either in whole blood or as isolated cells and later using blood of wild common loons exposed in vivo to a range of dietary MeHg and having a range of blood-Hg concentrations. Whole blood and isolated WBCs from captive chickens were exposed to a range of MeHg concentrations for 3 h. After MeHg exposure, cells were incubated with fluorescent latex microbeads (diameter = 1.75 microm), fixed, and analyzed for size, complexity, and fluorescent intensity by flow cytometry. MeHg significantly depressed phagocytic activity when added to isolated WBCs at concentrations > 0.01 microg/ml, but not when added to whole blood up to 50 microg/ml. Similarly, no significant relationship between the concentration of Hg in whole blood and phagocytic capacity of WBCs in free-living loons was observed. Our results suggest that the phagocytosis assay, although rapid and convenient for use in field studies with wildlife species, is not a responsive immunological indicator of MeHg exposure at environmentally realistic concentrations of blood-Hg in wild loons. Assays that measure other immunologic endpoints (e.g., bacterial killing assay, PHA skin test, and mitogen-induced lymphocyte proliferation) should be assessed with respect to their ability to detect MeHg immunotoxicity in wild birds.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Holloway J,Scheuhammer AM,Chan HMdoi
10.1007/s00244-002-2095-1subject
Has Abstractpub_date
2003-05-01 00:00:00pages
493-501issue
4eissn
0090-4341issn
1432-0703journal_volume
44pub_type
杂志文章abstract：:Although Antarctica is considered one of the most pristine areas on Earth, an accelerating human presence in this remote continent, such as scientific operations and functioning of numerous scientific stations, logistics, and tourism activities, has increased the risks of environmental impacts in recent decades. Durin...
journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Archives of environmental contamination and toxicology
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journal_title：Archives of environmental contamination and toxicology
pub_type： 杂志文章
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