Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.

Abstract:

:To elucidate the effect of oxitropium bromide (OTB), an anticholinergic drug, on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease (COPD), we performed the cycle exercise test on 19 patients with COPD (mean age, 72.0 +/- 1.9 years; mean FEV1, 1.28 +/- 0.07 L) before and after inhalation of OTB, 300 micrograms, or placebo, 300 micrograms, in randomized fashion. Spirometry was performed immediately before and 30 min after inhalation of either OTB or placebo. Dyspnea during exercise was evaluated using the Borg scale (BS) and the slope of the regression between BS and oxygen uptake (VO2) during exercise (Borg scale slope: BSS). Arterial oxygen saturation (SaO2) was continuously monitored by pulse oximeter during and after exercise. We also measured the recovery time, which was defined as the time to recover decreases in SaO2 after exercise. After OTB, spirometric indices were improved (delta FEV1 16.8 +/- 0.9 percent) and maximal VO2 during exercise increased significantly (from 986 +/- 46 ml/min to 1,156 +/- 55 ml/min, p < 0.01), but not after placebo. The maximal scores of BS and the BSS were significantly decreased after OTB, but not after placebo. Although the SaO2 at rest and during exercise did not differ with or without either OTB or placebo, the recovery time after OTB (77.3 +/- 6.8 s) was significantly shorter than that before administration (98.4 +/- 14.6 s) (p < 0.01). We conclude that the inhaled OTB produces small but significant improvement both in dyspnea during exercise and in exercise performance in stable COPD and may contribute to improve the quality of life in some patients with COPD. However, gas exchange during exercise of COPD patients is little affected by OTB.

journal_name

Chest

journal_title

Chest

authors

Teramoto S,Fukuchi Y,Orimo H

doi

10.1378/chest.103.6.1774

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

1774-82

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)42079-3

journal_volume

103

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CHEST文献大全
  • Closure of a ventricular septal defect through the aortic valve: a note of caution regarding resultant narrowing of the aortic valve annulus.

    abstract::Closure of ventricular septal defects through the aortic valve annulus has been described for a variety of cardiac anomalies. This technique is most appropriate when simultaneous aortic valve replacement is anticipated. A continuous suture through the patch material may produce a purse-string effect upon the aortic va...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.2.311

    authors: Stewart S

    更新日期:1976-08-01 00:00:00

  • Left-to-right shunt via left superior vena cava communication with left atrium.

    abstract::The findings in a 22-year-old man with Ebstein's anomaly of the tricuspid valve, Wolff-Parkinson-White syndrome, and a persistent left superior vena cava are reported. This is the first reported case of this combination of anomalies in which the atrial septum was intact and the left superior vena cava communicated wit...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.6.700

    authors: Lam W,Danoviz J,Witham D,Wyndham C,Rosen KM

    更新日期:1981-06-01 00:00:00

  • Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004-2010): a population-based study.

    abstract:BACKGROUND:The incidence and outcomes of disseminated intravascular coagulation (DIC) are incompletely defined. Therefore, we aimed to evaluate the trends in incidence and outcomes of critically ill patients with DIC. METHODS:We conducted a population-based, retrospective cohort study evaluating consecutively admitted...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-2112

    authors: Singh B,Hanson AC,Alhurani R,Wang S,Herasevich V,Cartin-Ceba R,Kor DJ,Gangat N,Li G

    更新日期:2013-05-01 00:00:00

  • Childhood asthma and the indoor environment in a subtropical area.

    abstract:STUDY OBJECTIVES:The objective of this study is to examine the relationship between indoor environmental factors and childhood asthma in a subtropical area. DESIGN:A case-control study was performed using participants of a prevalence survey that included 165 schoolchildren with asthma and 165 age- and gender-matched c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.2.393

    authors: Yang CY,Lin MC,Hwang KC

    更新日期:1998-08-01 00:00:00

  • Echocardiographic findings in a patient with Candida endocarditis of the aortic valve.

    abstract::The echocardiographic appearance of fungal endocarditis of the aortic valve is described in a patient who subsequently died from this disease. In addition, the progressive growth of the vegetation on serial echocardiograms was recorded, and premature closure of the mitral valve was absent, notwithstanding perforation ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.2.300

    authors: Arvan S,Cagin N,Levitt B,Kleid JJ

    更新日期:1976-08-01 00:00:00

  • Air within the spinal canal in spontaneous pneumomediastinum.

    abstract::Spontaneous pneumomediastinum is an uncommon benign condition that is occasionally associated with air within the spinal canal. We describe a further case in a 14-year-old girl and suggest a classification system based on a detailed review of the previous literature. Forty-eight patients with spontaneous pneumomediast...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.09-0514

    authors: Belotti EA,Rizzi M,Rodoni-Cassis P,Ragazzi M,Zanolari-Caledrerari M,Bianchetti MG

    更新日期:2010-05-01 00:00:00

  • Association of SERPINE2 with asthma.

    abstract:BACKGROUND:The "Dutch hypothesis" suggests that asthma and COPD have common genetic determinants. The serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) gene previously has been associated with COPD. We sought to determine whether SERPINE2 is associated with asthma ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-2973

    authors: Himes BE,Klanderman B,Ziniti J,Senter-Sylvia J,Soto-Quiros ME,Avila L,Celedón JC,Lange C,Mariani TJ,Lasky-Su J,Hersh CP,Raby BA,Silverman EK,Weiss ST,DeMeo DL

    更新日期:2011-09-01 00:00:00

  • Comparing two heat and moisture exchangers with one vaporizing humidifier in patients with minute ventilation greater than 10 L/min.

    abstract:STUDY OBJECTIVE:To evaluate in patients submitted to minute ventilation > 10 L/min the ability to preserve patients' heat and humidity of two heat and moisture exchangers (HMEs) and one vaporizing humidifier (VH). DESIGN:Prospective, randomized, comparative, non-blinded study. SETTING:Intensive care unit of a univers...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.107.5.1411

    authors: Martin C,Thomachot L,Quinio B,Viviand X,Albanese J

    更新日期:1995-05-01 00:00:00

  • Usefulness of bronchoscopic microsampling to detect the pathogenic bacteria of respiratory infection.

    abstract:BACKGROUND:Bronchoscopic microsampling (BMS) is a method in which a device consisting of a wire with a polyester probe at the tip is used to collect bronchial epithelial lining fluid with bronchoscopy. In this study, we bacteriologically investigated sample collection using BMS to incorporate BMS into diagnosis of resp...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-0989

    authors: Sasabayashi M,Yamazaki Y,Tsushima K,Hatayama O,Okabe T

    更新日期:2007-02-01 00:00:00

  • Postembolotherapy Pulmonary Arteriovenous Malformation Follow-Up: A Role for Graded Transthoracic Contrast Echocardiography Prior to High-Resolution Chest CT Scan.

    abstract:BACKGROUND:High-resolution chest CT (HRCT) scan is recommended after pulmonary arteriovenous malformation (PAVM) embolotherapy to assess for PAVM persistence and untreated PAVM growth. Graded transthoracic contrast echocardiography (TTCE) predicts the need for embolotherapy in PAVM screening. This study sought to deter...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.11.023

    authors: DePietro DM,Curnes NR,Chittams J,Ferrari VA,Pyeritz RE,Trerotola SO

    更新日期:2020-05-01 00:00:00

  • Predictability of oxygen desaturation during sleep in patients with cystic fibrosis : clinical, spirometric, and exercise parameters.

    abstract:BACKGROUND:The purpose of this study was to determine how common sleep-related desaturation with preserved awake resting pulse oximetric saturation (SpO(2)) was in a large cohort of adult cystic fibrosis (CF) patients with variable degrees of pulmonary disease. We then determined whether nocturnal desaturation could re...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.2.434

    authors: Frangolias DD,Wilcox PG

    更新日期:2001-02-01 00:00:00

  • Radionuclide scintiphotography in defining postoperative pulmonary vasoconstriction. Succesful results after tolazoline administration in a four-month-old infant with congenital heart disease.

    abstract::99mTechnetium macroaggregated albumin has successfully been used to define severe postoperative pulmonary vasoconstriction in a four-month-old boy with D-transposition of the great vessels who had undergone a Blalock-Hanlon surgical atrial septectomy. Radionuclide imaging documented clinically suspected pulmonary vaso...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.3.274

    authors: Moodie DS,Levy JM,Kahn DR,Lieberman LM,Pastakia B

    更新日期:1979-09-01 00:00:00

  • Coronary artery spasm complicating anaphylaxis secondary to skin disinfectant.

    abstract::We report a patient in whom presumed vasospasm of an angiographically normal coronary artery led to severe transmural myocardial ischemia. To our knowledge, this is the first case in which an allergic reaction to locally applied chlorhexidine caused such a severe reaction. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.113.5.1417

    authors: Conraads VM,Jorens PG,Ebo DG,Claeys MJ,Bosmans JM,Vrints CJ

    更新日期:1998-05-01 00:00:00

  • Efficacy of inhaled metaproterenol and orally-administered theophylline in patients with chronic airflow obstruction.

    abstract::To evaluate comparative bronchodilator efficacy with chronic airflow obstruction (CAO), we randomly administered to ten patients week-long treatments consisting of: inhaled metaproterenol from a metered dose canister (1.30 mg six times a day) and doses of a sustained-release theophylline formulation sufficient to achi...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.89.2.171

    authors: Dullinger D,Kronenberg R,Niewoehner DE

    更新日期:1986-02-01 00:00:00

  • The spectrum of building-related airway disorders: difficulty in retrospectively diagnosing building-related asthma.

    abstract:INTRODUCTION:The specific causes and mechanism(s) for asthma occurring among occupants of non-residential buildings with poor indoor air quality are not known, but allergic and nonallergic processes are possible explanations METHODS:Repeated indoor air quality measurements were made while employees were working in a b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.3.1720

    authors: Brooks SM,Spaul W,McCluskey JD

    更新日期:2005-09-01 00:00:00

  • Fatal pulmonary embolism in spinal cord injury.

    abstract::Fatal pulmonary embolism (PE) is a major cause of mortality in patients with spinal cord injury. In order to ascertain those characteristics that might predict this event, we reviewed the records of all patients with autopsy-proven massive PE admitted to a regional spinal cord care center over a 5-year period. The inf...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.3.853

    authors: Green D,Twardowski P,Wei R,Rademaker AW

    更新日期:1994-03-01 00:00:00

  • CD8+ cell-dominant alveolitis in pulmonary sarcoidosis.

    abstract::A 55-year-old woman had bilateral hilar lymphadenopathy and retinouveitis. Microscopic examination of a biopsy specimen from a mediastinal lymph node revealed noncaseating epithelioid cell granulomas. Since granulomatous diseases of infectious origin and sarcoid reaction were reasonably excluded, she was diagnosed as ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.1.228

    authors: Yamaguchi E,Haneda H,Okazaki N,Abe S,Kawakami Y,Nojima T

    更新日期:1989-01-01 00:00:00

  • Cardiac workload in patients with sleep-disordered breathing early after acute myocardial infarction.

    abstract:BACKGROUND:Sleep-disordered breathing (SDB) may promote an increase in cardiac workload early after acute myocardial infarction (AMI). We tested the hypothesis that in the early phase after AMI, SDB is associated with increased 24-h arterial BP, heart rate (HR), and, thus, cardiac workload. METHODS:In this prospective...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-1930

    authors: Hetzenecker A,Buchner S,Greimel T,Satzl A,Luchner A,Debl K,Husser O,Hamer OW,Fellner C,Riegger GAJ,Pfeifer M,Arzt M

    更新日期:2013-05-01 00:00:00

  • Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma.

    abstract:STUDY OBJECTIVES:To clarify the pathophysiologic features of the relation between asthma and obesity, we measured the effects of weight reduction on peak expiratory flow (PEF) variability and airways obstruction, compared to simultaneous changes in lung volumes and ventilatory mechanics in obese patients with stable as...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.5.1315

    authors: Hakala K,Stenius-Aarniala B,Sovijärvi A

    更新日期:2000-11-01 00:00:00

  • Subepicardial infarction, myocardial impression, and ventricular penetration by sutureless electrode and leads.

    abstract::Postmortem examination two weeks following implantation of a demand pacemaker with sutureless electrodes demonstrated that (1) the loops of intrapericardial electrode leads indented the myocardium and produced a circumscribed area of subepicardial necrosis, and (2) one of the electrode coils protruded into the right v...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.1.80

    authors: Steinke WE,Thomas FT,ul Hassan Z,Mendoza RA,Gear AS

    更新日期:1976-07-01 00:00:00

  • Persisting symptoms despite permanent pacing. Incidence, causes, and follow-up.

    abstract::Persisting symptoms, consisting of palpitations, dizziness, or syncope, were found in 49 of 570 consecutively followed patients (8.6 percent) with permanent pacemakers (PM). Among 540 patients with ventricular PM, 19 had syncope and 24 dizziness; among 30 patients with dual-chamber PM, five had palpitations and one di...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.2.207

    authors: Hoffman A,Jost M,Pfisterer M,Burkart F,Burckhardt D

    更新日期:1984-02-01 00:00:00

  • Asbestos fibers in laryngeal tissues. Findings in two patients with asbestosis associated with laryngeal tumors.

    abstract::Significant concentrations of asbestos fibers have been found in samples of laryngeal tissue from two patients with past exposure to asbestos and associated asbestosis. In one case, there was a polyp on a vocal cord and in the other one a laryngeal carcinoma. These findings could provide an indication of a local carci...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.6.697

    authors: Hirsch A,Bignon J,Sebastien P,Gaudichet A

    更新日期:1979-12-01 00:00:00

  • Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia.

    abstract:OBJECTIVE:To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). DESIGN:Retrospective analysis of data from two prospective, randomized, double-blind studies. SETTING:Multinational study with 134 site...

    journal_title:Chest

    pub_type: 杂志文章

    doi:

    authors: Wunderink RG,Rello J,Cammarata SK,Croos-Dabrera RV,Kollef MH

    更新日期:2003-11-01 00:00:00

  • Increased risk of lost workdays prior to the diagnosis of sleep apnea.

    abstract:BACKGROUND:The impact of sleep apnea on work disability, in terms of sickness absence and disability pension, is unclear. We sought to estimate the total number of lost workdays caused by sleep apnea either due to medically certified sickness absences or disability pensions during the 5 years prior to the year of a sle...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2201

    authors: Sjösten N,Vahtera J,Salo P,Oksanen T,Saaresranta T,Virtanen M,Pentti J,Kivimäki M

    更新日期:2009-07-01 00:00:00

  • PEEP and "reverse mismatch". A case where less PEEP is best.

    abstract::A V/Q lung scan was obtained in a patient with LLL collapse who was receiving IPPV and PEEP. This revealed absent ventilation and hyperperfusion to the collapsed lobe. After a reduction in PEEP from 12 to 5 cm H2O, a repeat V/Q scan showed a more even distribution of pulmonary perfusion. Arterial hypoxemia improved. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.4.1034

    authors: Hawker FH,Torzillo PJ,Southee AE

    更新日期:1991-04-01 00:00:00

  • Frequency dependent phase and amplitude differences between simulated mouth and pleural pressures during panting. Demonstration with a mechanical model.

    abstract::A mechanical model was employed to examine phase and amplitude relationships between simulated pleural and mouth pressures during panting at different frequencies with and without lower airway obstruction and with rigid or flaccid extrathoracic airways. Results confirm the hypothesis that, in the presence of lower air...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.86.4.589

    authors: Knudson RJ,Knudson DE

    更新日期:1984-10-01 00:00:00

  • Dangerous curves. A perspective on exercise, lactate, and the anaerobic threshold.

    abstract::A number of general observations can be made from these recent studies. Lactate is a ubiquitous substance that is produced and removed from the body at all times, even at rest, both with and without the availability of oxygen. It is now recognized that lactate accumulates in the blood for several reasons, not just the...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.111.3.787

    authors: Myers J,Ashley E

    更新日期:1997-03-01 00:00:00

  • Alternans of the ST segment in variant angina. Incidence, time course and relation to ventricular arrhythmias during ambulatory electrocardiographic recording.

    abstract::The ST alternans was recorded during at least one ischemic attack with ST elevation in nine of 65 patients with variant angina. The magnitude and duration of ST elevation during ischemic attacks were significantly greater in patients with than in those without ST alternans. It always appeared during the occlusion phas...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.3.587

    authors: Turitto G,El-Sherif N

    更新日期:1988-03-01 00:00:00

  • Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats.

    abstract:STUDY OBJECTIVE:To determine if animals with abnormally low albumin levels are more susceptible to the effects of hypercapnia on BP compared to normal animals. DESIGN:Prospective, controlled laboratory experiment. SETTING:University research laboratory. ANIMALS:Eighteen male Sprague-Dawley rats: 6 rats 10 to 12 week...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-2069

    authors: Gómez JL,Gunnerson KJ,Song M,Li J,Kellum JA

    更新日期:2007-05-01 00:00:00

  • Long-term Outcomes After Stepping Down Asthma Controller Medications: A Claims-Based, Time-to-Event Analysis.

    abstract:BACKGROUND:Long-term outcomes after stepping down asthma medications are not well described. METHODS:This study was a retrospective time-to-event analysis of individuals diagnosed with asthma who stepped down their asthma controller medications using a US claims database spanning 2000 to 2012. Four-month intervals wer...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.15-0301

    authors: Rank MA,Johnson R,Branda M,Herrin J,van Houten H,Gionfriddo MR,Shah ND

    更新日期:2015-09-01 00:00:00