Are positive axillary nodes in breast cancer markers for incurable disease?

Abstract:

OBJECTIVE:This study was designed to determine if resection of positive regional nodes in patients with breast cancer provided a group of cured patients. SUMMARY BACKGROUND DATA:Previous studies of long-term follow-up of patients with breast cancer have demonstrated that 30% of patients with positive nodes may be alive at 10 or 20 years. Randomized, prospective studies have not shown a difference in survival between modified radical and total mastectomy. METHODS:The authors analyzed the statistical basis of randomized, prospective studies of breast cancer. Patients from University and Kings County Hospital with breast cancer were observed (n = 1024) and the 10-year survival curves were analyzed. Data from the Surveillance, Epidemiology, and End Results (SEER) program were evaluated to determine the prognosis of patients with positive-node breast cancer who survived 10 and 15 years. RESULTS:The authors found that no current randomized study of primary treatment of breast cancer has the power to determine the advantage of one treatment over another if the primary cancer is treated. Additionally, evaluation of the patients in this study demonstrated that those with regional disease usually had a recurrence by 7 years; however, at 10 years, 30% are still alive and have the same prognosis as patients with negative-node breast cancer. CONCLUSIONS:Regional breast cancer is a curable disease in some resected patients.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Gardner B,Feldman J

doi

10.1097/00000658-199309000-00006

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

270-5; discussion 275-8

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

218

pub_type

杂志文章
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    journal_title:Annals of surgery

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    authors: Smadja C,Franco D

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  • Single-incision Laparoscopic Appendectomy Versus Conventional Laparoscopic Appendectomy: Experiences From 1208 Cases of Single-incision Laparoscopic Appendectomy. Experiences From 1208 Cases of Single-incision Laparoscopic Appendectomy.

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    doi:10.1097/00000658-198005000-00004

    authors: Annest SJ,Gottlieb M,Paloski WH,Stratton H,Newell JC,Dutton R,Powers SR Jr

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  • The cost of not wearing seat belts. A comparison of outcome in 3396 patients.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199302000-00005

    authors: Rutledge R,Lalor A,Oller D,Hansen A,Thomason M,Meredith W,Foil MB,Baker C

    更新日期:1993-02-01 00:00:00

  • Metastatic carcinoid to the liver treated by hepatic dearterialization.

    abstract::A historical review of work bearing on the rationale for hepatic artery ligation in the treatment of malignant disease in the liver is presented, particularly the early work showing that malignant disease of the liver is supplied primarily by the arterial circulation and not by the portal. A review is presented of som...

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    doi:10.1097/00000658-197409000-00008

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  • Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized trial.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199504000-00004

    authors: Izbicki JR,Bloechle C,Knoefel WT,Kuechler T,Binmoeller KF,Broelsch CE

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  • Platelet-rich fibrin versus albumin in surgical wound repair: a randomized trial with paired design.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    authors: Agerskov K,Faris I,Tønnesen KH,Kristensen P,Christensen SC

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    authors: Dudrick SJ,Daly JM,Castro G,Akhtar M

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    pub_type: 杂志文章,随机对照试验

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  • Reconstruction for chronic dysfunction of ileoanal pouches.

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    pub_type: 杂志文章

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    更新日期:1999-02-01 00:00:00

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